学術雑誌論文

学術雑誌論文

text

Tissue Engineering - Part B: Reviews. 2022, 28(1)

Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective

Mary Ann Liebert

英語

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2022-02-15

https://doi.org/10.1089/ten.teb.2020.0352

Hara E.S., Okada M., Nagaoka N., et al. Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective. Tissue Engineering - Part B: Reviews, 28, 1, 246. https://doi.org/10.1089/ten.teb.2020.0352.

Bone regeneration was one of the earliest fields to develop in the context of tissue regeneration, and currently, repair of small-sized bone defects has reached a high success rate. Future researches are expected to incorporate more advanced techniques toward achieving rapid bone repair and modulation of the regenerated bone quality. For these purposes, it is important to have a more integrative understanding of the mechanisms of bone formation and maturation from multiple perspectives and to incorporate these new concepts into the development and designing of novel materials and techniques for bone regeneration. This review focuses on the analysis of the earliest stages of bone tissue development from the biology, material science, and engineering perspectives for a more integrative understanding of bone formation and maturation, and for the development of novel biology-based engineering approaches for tissue synthesis in vitro. More specifically, the authors describe the systematic methodology that allowed the understanding of the different nucleation sites in intramembranous and endochondral ossification, the space-making process for mineral formation and growth, as well as the process of apatite crystal cluster growth in vivo in the presence of suppressing biomolecules. A detailed understanding of the developmental process of bone tissue leads to the acquisition of useful information for the bone tissue fabrication. This review summarizes the study of the calcification process of the calvaria and epiphyses from an engineering perspective and provides useful information for the realization of bone tissue biofabrication. Here, we describe the new mechanism of space formation for mineralization such as rupture of chondrocytes and disruption of cell-cell adhesion. We also describe the roles of nucleation site such as cell membrane nanofragments and matrix vesicles.

This article is licensed under a Creative Commons Attribution 4.0 International License.

89759

Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective

Mary Ann Liebert

英語

2022-02-15

Tissue Engineering - Part B: Reviews

28

1

https://doi.org/10.1089/ten.teb.2020.0352

https://hdl.handle.net/11094/89759