Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity

Lee, Sungho; Nagata, Fukue; Kato, Katsuya; Kasuga, Toshihiro; Nakano, Takayoshi

doi:https://doi.org/10.1002/jbm.a.37067

Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity

Lee, Sungho; Nagata, Fukue; Kato, Katsuya et al.

Journal of Biomedical Materials Research - Part A, 2020, 109(5), 788-803

アクセス数:107件（2025-04-03 22:09 集計）

固定URL: https://hdl.handle.net/11094/89786

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
JBiomedMaterResPartA_109_5_788	pdf	なし	9.35 MB	54	2022.12.26

Creative Commons : 表示 - 非営利

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity
著者	NRID 1000020850001 1000020850001 著者名 Lee, Sungho
	NRID 1000000357633 1000000357633 著者名 Nagata, Fukue
	NRID 1000070356781 1000070356781 著者名 Kato, Katsuya
	NRID 1000030233729 1000030233729 著者名 Kasuga, Toshihiro
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
内容	Lee S., Nagata F., Kato K., et al. Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity. Journal of Biomedical Materials Research - Part A, 109, 5, 788. https://doi.org/10.1002/jbm.a.37067.
抄録	Reconstruction of organ-specific architecture is necessary to recover the original organ function. The anisotropic structure of bone tissue is strongly related to the collagen fibril alignment and bone apatite crystal direction. Bone regeneration indicates following two main process; first, restoration of bone mineral density (BMD; bone quantity), and second, restoring bone apatite c-axis orientation (bone quality). In addition to BMD, bone quality is the most important factor among bone mechanical properties. Recovery of the original bone function requires development of novel scaffolds with simultaneous reconstruction of bone quality and quantity. Herein, novel orthophosphosilicate glass (PSG)/poly(lactic acid) composite anisotropic scaffolds were developed to control cell alignment and enhance bone formation, which are important for the simultaneous reconstruction of bone quality and quantity. The strategy to control cell alignment and bone formation involved designing anisotropic scaffolds in combination with the release of therapeutic ions by PSGs. The morphology of fibrous scaffolds containing PSGs was quantitatively designed using electrospinning. This successfully modulated cell alignment and subsequent bone apatite c-axis orientation along the fiber-oriented direction. The released silicate and Mg2+ ions from PSGs in scaffolds improved cell adhesion, proliferation, and calcification. To best of our knowledge, this is the first report demonstrating that the anisotropic scaffolds containing bioactive glasses regenerate bone tissues with simultaneous reconstruction of bone quality and quantity via stimulating osteoblasts by inorganic ions and designing morphology of scaffolds.
出版者	John Wiley and Sons
収録物名	Journal of Biomedical Materials Research - Part A
巻(号)	109(5)
ページ	788-803
刊行年月	2020-07-27
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89786
PISSN	15493296
eISSN	15524965
NCID	AA11881516
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1002/jbm.a.37067
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Biomedical Materials Research - Part A. 2020, 109(5), p. 788-803
DC.title	Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity
DC.creator	Lee, Sungho
	Nagata, Fukue
	Kato, Katsuya
	Kasuga, Toshihiro
	Nakano, Takayoshi
DC.publisher	John Wiley and Sons
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-07-27
DC.identifier	https://doi.org/10.1002/jbm.a.37067
DC.description	Lee S., Nagata F., Kato K., et al. Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity. Journal of Biomedical Materials Research - Part A, 109, 5, 788. https://doi.org/10.1002/jbm.a.37067.
DCTERMS.abstract	Reconstruction of organ-specific architecture is necessary to recover the original organ function. The anisotropic structure of bone tissue is strongly related to the collagen fibril alignment and bone apatite crystal direction. Bone regeneration indicates following two main process; first, restoration of bone mineral density (BMD; bone quantity), and second, restoring bone apatite c-axis orientation (bone quality). In addition to BMD, bone quality is the most important factor among bone mechanical properties. Recovery of the original bone function requires development of novel scaffolds with simultaneous reconstruction of bone quality and quantity. Herein, novel orthophosphosilicate glass (PSG)/poly(lactic acid) composite anisotropic scaffolds were developed to control cell alignment and enhance bone formation, which are important for the simultaneous reconstruction of bone quality and quantity. The strategy to control cell alignment and bone formation involved designing anisotropic scaffolds in combination with the release of therapeutic ions by PSGs. The morphology of fibrous scaffolds containing PSGs was quantitatively designed using electrospinning. This successfully modulated cell alignment and subsequent bone apatite c-axis orientation along the fiber-oriented direction. The released silicate and Mg2+ ions from PSGs in scaffolds improved cell adhesion, proliferation, and calcification. To best of our knowledge, this is the first report demonstrating that the anisotropic scaffolds containing bioactive glasses regenerate bone tissues with simultaneous reconstruction of bone quality and quantity via stimulating osteoblasts by inorganic ions and designing morphology of scaffolds.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	89786
citation_title	Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity
citation_author	Lee, Sungho
	Nagata, Fukue
	Kato, Katsuya
	Kasuga, Toshihiro
	Nakano, Takayoshi
citation_publisher	John Wiley and Sons
citation_language	英語
citation_date	2020-07-27
citation_journal_title	Journal of Biomedical Materials Research - Part A
citation_volume	109
citation_issue	5
citation_firstpage	788
citation_lastpage	803
citation_doi	https://doi.org/10.1002/jbm.a.37067
citation_public_url	https://hdl.handle.net/11094/89786

Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity

閲覧可能ファイル

論文情報

論文詳細を表示