Type I Angiotensin II Receptor Blockade Reduces Uremia-Induced Deterioration of Bone Material Properties

Wakamatsu, Takuya; Iwasaki, Yoshiko; Yamamoto, Suguru; Matsuo, Koji; Goto, Shin; Narita, Ichiei; Kazama, Junichiro J.; Tanaka, Kennichi; Ito, Akemi; Ozasa, Ryosuke; Nakano, Takayoshi; Miyakoshi, Chisato; Onishi, Yoshihiro; Fukuma, Shingo; Fukuhara, Shunichi; Yamato, Hideyuki; Fukagawa, Masafumi; Akizawa, Tadao

doi:https://doi.org/10.1002/jbmr.4159

Type I Angiotensin II Receptor Blockade Reduces Uremia-Induced Deterioration of Bone Material Properties

Wakamatsu, Takuya; Iwasaki, Yoshiko; Yamamoto, Suguru et al.

Journal of Bone and Mineral Research, 2021, 36(1), 67-79

アクセス数:355件（2025-04-03 21:59 集計）

固定URL: https://hdl.handle.net/11094/89795

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タイトル	Type I Angiotensin II Receptor Blockade Reduces Uremia-Induced Deterioration of Bone Material Properties
著者	著者名 Wakamatsu, Takuya
	著者名 Iwasaki, Yoshiko
	NRID 1000070444156 1000070444156 著者名 Yamamoto, Suguru
	著者名 Matsuo, Koji
	NRID 1000000463969 1000000463969 著者名 Goto, Shin
	NRID 1000020272817 1000020272817 著者名 Narita, Ichiei
	NRID 1000010345499 1000010345499 著者名 Kazama, Junichiro J.
	NRID 1000010126427 1000010126427 著者名 Tanaka, Kennichi
	著者名 Ito, Akemi
	NRID 1000080845347 1000080845347 ORCID 0000-0002-2773-072X 0000-0002-2773-072X researchmap permalink ozasa_r ozasa_r Scopus Author ID 56202812400 56202812400 著者名 Ozasa, Ryosuke
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
	著者名 Miyakoshi, Chisato
	著者名 Onishi, Yoshihiro
	NRID 1000060706703 1000060706703 著者名 Fukuma, Shingo
	NRID 1000030238505 1000030238505 著者名 Fukuhara, Shunichi
	著者名 Yamato, Hideyuki
	著者名 Fukagawa, Masafumi
	著者名 Akizawa, Tadao
内容	Wakamatsu T., Iwasaki Y., Yamamoto S., et al. Type I Angiotensin II Receptor Blockade Reduces Uremia-Induced Deterioration of Bone Material Properties. Journal of Bone and Mineral Research, 36, 1, 67. https://doi.org/10.1002/jbmr.4159.
抄録	Chronic kidney disease (CKD) is associated with a high incidence of fractures. However, the pathophysiology of this disease is not fully understood, and limited therapeutic interventions are available. This study aimed to determine the impact of type 1 angiotensin II receptor blockade (AT-1RB) on preventing CKD-related fragility fractures and elucidate its pharmacological mechanisms. AT-1RB use was associated with a lower risk of hospitalization due to fractures in 3276 patients undergoing maintenance hemodialysis. In nephrectomized rats, administration of olmesartan suppressed osteocyte apoptosis, skeletal pentosidine accumulation, and apatite disorientation, and partially inhibited the progression of the bone elastic mechanical properties, while the bone mass was unchanged. Olmesartan suppressed angiotensin II-dependent oxidation stress and apoptosis in primary cultured osteocytes in vitro. In conclusion, angiotensin II-dependent intraskeletal oxidation stress deteriorated the bone elastic mechanical properties by promoting osteocyte apoptosis and pentosidine accumulation. Thus, AT-1RB contributes to the underlying pathogenesis of abnormal bone quality in the setting of CKD, possibly by oxidative stress. © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
出版者	John Wiley and Sons
収録物名	Journal of Bone and Mineral Research
巻(号)	36(1)
ページ	67-79
刊行年月	2021-08-12
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89795
PISSN	08840431
eISSN	15234681
NCID	AA10688587
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1002/jbmr.4159
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Bone and Mineral Research. 2021, 36(1), p. 67-79
DC.title	Type I Angiotensin II Receptor Blockade Reduces Uremia-Induced Deterioration of Bone Material Properties
DC.creator	Wakamatsu, Takuya
	Iwasaki, Yoshiko
	Yamamoto, Suguru
	Matsuo, Koji
	Goto, Shin
	Narita, Ichiei
	Kazama, Junichiro J.
	Tanaka, Kennichi
	Ito, Akemi
	Ozasa, Ryosuke
	Nakano, Takayoshi
	Miyakoshi, Chisato
	Onishi, Yoshihiro
	Fukuma, Shingo
	Fukuhara, Shunichi
	Yamato, Hideyuki
	Fukagawa, Masafumi
	Akizawa, Tadao
DC.publisher	John Wiley and Sons
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-08-12
DC.identifier	https://doi.org/10.1002/jbmr.4159
DC.description	Wakamatsu T., Iwasaki Y., Yamamoto S., et al. Type I Angiotensin II Receptor Blockade Reduces Uremia-Induced Deterioration of Bone Material Properties. Journal of Bone and Mineral Research, 36, 1, 67. https://doi.org/10.1002/jbmr.4159.
DCTERMS.abstract	Chronic kidney disease (CKD) is associated with a high incidence of fractures. However, the pathophysiology of this disease is not fully understood, and limited therapeutic interventions are available. This study aimed to determine the impact of type 1 angiotensin II receptor blockade (AT-1RB) on preventing CKD-related fragility fractures and elucidate its pharmacological mechanisms. AT-1RB use was associated with a lower risk of hospitalization due to fractures in 3276 patients undergoing maintenance hemodialysis. In nephrectomized rats, administration of olmesartan suppressed osteocyte apoptosis, skeletal pentosidine accumulation, and apatite disorientation, and partially inhibited the progression of the bone elastic mechanical properties, while the bone mass was unchanged. Olmesartan suppressed angiotensin II-dependent oxidation stress and apoptosis in primary cultured osteocytes in vitro. In conclusion, angiotensin II-dependent intraskeletal oxidation stress deteriorated the bone elastic mechanical properties by promoting osteocyte apoptosis and pentosidine accumulation. Thus, AT-1RB contributes to the underlying pathogenesis of abnormal bone quality in the setting of CKD, possibly by oxidative stress. © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89795
citation_title	Type I Angiotensin II Receptor Blockade Reduces Uremia-Induced Deterioration of Bone Material Properties
citation_author	Wakamatsu, Takuya
	Iwasaki, Yoshiko
	Yamamoto, Suguru
	Matsuo, Koji
	Goto, Shin
	Narita, Ichiei
	Kazama, Junichiro J.
	Tanaka, Kennichi
	Ito, Akemi
	Ozasa, Ryosuke
	Nakano, Takayoshi
	Miyakoshi, Chisato
	Onishi, Yoshihiro
	Fukuma, Shingo
	Fukuhara, Shunichi
	Yamato, Hideyuki
	Fukagawa, Masafumi
	Akizawa, Tadao
citation_publisher	John Wiley and Sons
citation_language	英語
citation_date	2021-08-12
citation_journal_title	Journal of Bone and Mineral Research
citation_volume	36
citation_issue	1
citation_firstpage	67
citation_lastpage	79
citation_doi	https://doi.org/10.1002/jbmr.4159
citation_public_url	https://hdl.handle.net/11094/89795

Type I Angiotensin II Receptor Blockade Reduces Uremia-Induced Deterioration of Bone Material Properties

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