A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement

Matsugaki, Aira; Matsumoto, Shun; Nakano, Takayoshi

doi:https://doi.org/10.3390/ijms21186659

A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement

Matsugaki, Aira; Matsumoto, Shun; Nakano, Takayoshi

International Journal of Molecular Sciences, 2020, 21(18)

アクセス数:114件（2025-04-03 22:01 集計）

固定URL: https://hdl.handle.net/11094/89798

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タイトル	A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement
著者	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 著者名 Matsugaki, Aira
	著者名 Matsumoto, Shun
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
キーワード等	Bone microstructure
	Cell arrangement
	Interleukin-6
	Macrophage
	Osteoblast
内容	Matsugaki A., Matsumoto S., Nakano T.. A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement. International Journal of Molecular Sciences, 21, 18, 1. https://doi.org/10.3390/ijms21186659.
抄録	Inflammatory disorders are associated with bone destruction; that is, deterioration in bone cell activities are under the control of the innate immune system. Macrophages play a central role in innate immunity by switching their polarized phenotype. A disturbed immune system causes aberrance in the ordered bone matrix microarrangement, which is a dominant determinant of bone tissue functionalization. However, the precise relationship between the immune system and bone tissue organization is unknown. In this study, the controlled in vitro co-culture assay results showed that M1-polarized macrophages disrupted the osteoblast alignment, which directly modulate the oriented bone matrix organization, by secreting pro-inflammatory cytokines. Notably, interleukin6 was found to be a key regulator of unidirectional osteoblast alignment. Our results demonstrated that inflammatory diseases triggered bone dysfunction by regulating the molecular interaction between the immune system and bone tissue organization. These findings may contribute to the development of therapeutic targets for inflammatory disorders, including rheumatoid arthritis.
出版者	MDPI
収録物名	International Journal of Molecular Sciences
巻(号)	21(18)
刊行年月	2020-09-11
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89798
PISSN	16616596
eISSN	14220067
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.3390/ijms21186659
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	International Journal of Molecular Sciences. 2020, 21(18)
DC.title	A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement
DC.creator	Matsugaki, Aira
	Matsumoto, Shun
	Nakano, Takayoshi
DC.publisher	MDPI
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-09-11
DC.identifier	https://doi.org/10.3390/ijms21186659
DC.subject	Bone microstructure
	Cell arrangement
	Interleukin-6
	Macrophage
	Osteoblast
DC.description	Matsugaki A., Matsumoto S., Nakano T.. A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement. International Journal of Molecular Sciences, 21, 18, 1. https://doi.org/10.3390/ijms21186659.
DCTERMS.abstract	Inflammatory disorders are associated with bone destruction; that is, deterioration in bone cell activities are under the control of the innate immune system. Macrophages play a central role in innate immunity by switching their polarized phenotype. A disturbed immune system causes aberrance in the ordered bone matrix microarrangement, which is a dominant determinant of bone tissue functionalization. However, the precise relationship between the immune system and bone tissue organization is unknown. In this study, the controlled in vitro co-culture assay results showed that M1-polarized macrophages disrupted the osteoblast alignment, which directly modulate the oriented bone matrix organization, by secreting pro-inflammatory cytokines. Notably, interleukin6 was found to be a key regulator of unidirectional osteoblast alignment. Our results demonstrated that inflammatory diseases triggered bone dysfunction by regulating the molecular interaction between the immune system and bone tissue organization. These findings may contribute to the development of therapeutic targets for inflammatory disorders, including rheumatoid arthritis.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89798
citation_title	A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement
citation_author	Matsugaki, Aira
	Matsumoto, Shun
	Nakano, Takayoshi
citation_publisher	MDPI
citation_language	英語
citation_date	2020-09-11
citation_journal_title	International Journal of Molecular Sciences
citation_volume	21
citation_issue	18
citation_doi	https://doi.org/10.3390/ijms21186659
citation_public_url	https://hdl.handle.net/11094/89798

A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement

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