UVA-activated riboflavin promotes collagen crosslinking to prevent root caries

Uemura, R.; Miura, J.; Ishimoto, T.; Yagi, K.; Matsuda, Y.; Shimizu, M.; Nakano, T.; Hayashi, M.

doi:https://doi.org/10.1038/s41598-018-38137-7

UVA-activated riboflavin promotes collagen crosslinking to prevent root caries

Uemura, R.; Miura, J.; Ishimoto, T. et al.

Scientific Reports, 2019, 9, 1252

アクセス数:818件（2025-07-01 14:26 集計）

固定URL: https://hdl.handle.net/11094/89811

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タイトル	UVA-activated riboflavin promotes collagen crosslinking to prevent root caries
著者	著者名 Uemura, R.
	著者名 Miura, J.
	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 著者名 Ishimoto, T.
	著者名 Yagi, K.
	著者名 Matsuda, Y.
	著者名 Shimizu, M.
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, T.
	NRID 1000040271027 1000040271027 researchmap permalink read0185244 read0185244 Scopus Author ID 26021225700 26021225700 著者名 Hayashi, M.
内容	Uemura R., Miura J., Ishimoto T., et al. UVA-activated riboflavin promotes collagen crosslinking to prevent root caries. Scientific Reports, 9, 1, 1252. https://doi.org/10.1038/s41598-018-38137-7.
抄録	Root caries is an increasingly problem in aging societies with severe implications for the general health and wellbeing of large numbers of people. Strengthening type-I collagen, a major organic component of human dentin, has proved effective in preventing root caries. This study sought to determine whether exposure to riboflavin followed by UVA irradiation (RF/UVA) could promote additional collagen crosslinking, and thus improve the acid and enzymatic resistance of human dentin under simulated oral environments. If so, it could offer potential for treatment of the intractable problem of root caries. The greatest flexural strengths were found in dentin exposed to a 0.1% riboflavin solution for 1 minute followed by 1,600 mW/cm2 UVA irradiation for 10 minutes. Mineral loss and lesion depth were significantly lower in the RF/UVA group than in the control group. The microstructures of dentinal tubules and collagen networks after RF/UVA treatment retained their original forms after acidic and enzymatic degradation. In conclusion, RF/UVA treatment may be a new method for preventing root caries with promising prospects for clinical application.
出版者	Nature Publishing Group
収録物名	Scientific Reports
巻(号)	9
ページ	1252
刊行年月	2019-02-04
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89811
eISSN	20452322
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41598-018-38137-7
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Scientific Reports. 2019, 9, p. 1252
DC.title	UVA-activated riboflavin promotes collagen crosslinking to prevent root caries
DC.creator	Uemura, R.
	Miura, J.
	Ishimoto, T.
	Yagi, K.
	Matsuda, Y.
	Shimizu, M.
	Nakano, T.
	Hayashi, M.
DC.publisher	Nature Publishing Group
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2019-02-04
DC.identifier	https://doi.org/10.1038/s41598-018-38137-7
DC.description	Uemura R., Miura J., Ishimoto T., et al. UVA-activated riboflavin promotes collagen crosslinking to prevent root caries. Scientific Reports, 9, 1, 1252. https://doi.org/10.1038/s41598-018-38137-7.
DCTERMS.abstract	Root caries is an increasingly problem in aging societies with severe implications for the general health and wellbeing of large numbers of people. Strengthening type-I collagen, a major organic component of human dentin, has proved effective in preventing root caries. This study sought to determine whether exposure to riboflavin followed by UVA irradiation (RF/UVA) could promote additional collagen crosslinking, and thus improve the acid and enzymatic resistance of human dentin under simulated oral environments. If so, it could offer potential for treatment of the intractable problem of root caries. The greatest flexural strengths were found in dentin exposed to a 0.1% riboflavin solution for 1 minute followed by 1,600 mW/cm2 UVA irradiation for 10 minutes. Mineral loss and lesion depth were significantly lower in the RF/UVA group than in the control group. The microstructures of dentinal tubules and collagen networks after RF/UVA treatment retained their original forms after acidic and enzymatic degradation. In conclusion, RF/UVA treatment may be a new method for preventing root caries with promising prospects for clinical application.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89811
citation_title	UVA-activated riboflavin promotes collagen crosslinking to prevent root caries
citation_author	Uemura, R.
	Miura, J.
	Ishimoto, T.
	Yagi, K.
	Matsuda, Y.
	Shimizu, M.
	Nakano, T.
	Hayashi, M.
citation_publisher	Nature Publishing Group
citation_language	英語
citation_date	2019-02-04
citation_journal_title	Scientific Reports
citation_volume	9
citation_firstpage	1252
citation_doi	https://doi.org/10.1038/s41598-018-38137-7
citation_public_url	https://hdl.handle.net/11094/89811

UVA-activated riboflavin promotes collagen crosslinking to prevent root caries

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