Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation

Lee, Sungho; Matsugaki, Aira; Kasuga, Toshihiro; Nakano, Takayoshi

doi:https://doi.org/10.1002/jbm.a.36619

Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation

Lee, Sungho; Matsugaki, Aira; Kasuga, Toshihiro et al.

Journal of Biomedical Materials Research - Part A, 2019, 107(5), 1031-1041

アクセス数:126件（2025-04-03 21:24 集計）

固定URL: https://hdl.handle.net/11094/89821

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タイトル	Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation
著者	NRID 1000020850001 1000020850001 著者名 Lee, Sungho
	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 著者名 Matsugaki, Aira
	NRID 1000030233729 1000030233729 著者名 Kasuga, Toshihiro
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
内容	Lee S., Matsugaki A., Kasuga T., et al. Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation. Journal of Biomedical Materials Research - Part A, 107, 5, 1031. https://doi.org/10.1002/jbm.a.36619.
抄録	During the bone regeneration process, the anisotropic microstructure of bone tissue (bone quality) recovers much later than bone mass (bone quantity), resulting in severe mechanical dysfunction in the bone. Hence, restoration of bone microstructure in parallel with bone mass is necessary for ideal bone tissue regeneration; for this, development of advanced bifunctional biomaterials, which control both the quality and quantity in regenerated bone, is required. We developed novel oriented bioactive glass/poly(lactic acid) composite scaffolds by introducing an effective methodology for controlling cell alignment and proliferation, which play important roles for achieving bone anisotropy and bone mass, respectively. Our strategy is to manipulate the cell alignment and proliferation by the morphological control of the scaffolds in combination with controlled ion release from bioactive glasses. We quantitatively controlled the morphology of fibermats containing bioactive glasses by electrospinning, which successfully induced cell alignment along the fibermats. Also, the substitution of CaO in Bioglass®(45S5) with MgO and SrO improved osteoblast proliferation, indicating that dissolved Mg 2+ and Sr 2+ ions promoted cell adhesion and proliferation. Our results indicate that the fibermats developed in this work are candidates for the scaffolds to bone tissue regeneration that enable recovery of both bone quality and bone quantity. © 2019 The Authors. journal Of Biomedical Materials Research Part A Published By Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1031–1041, 2019.
出版者	John Wiley and Sons
収録物名	Journal of Biomedical Materials Research - Part A
巻(号)	107(5)
ページ	1031-1041
刊行年月	2019-01-24
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89821
PISSN	15493296
eISSN	15524965
NCID	AA11881516
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1002/jbm.a.36619
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Biomedical Materials Research - Part A. 2019, 107(5), p. 1031-1041
DC.title	Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation
DC.creator	Lee, Sungho
	Matsugaki, Aira
	Kasuga, Toshihiro
	Nakano, Takayoshi
DC.publisher	John Wiley and Sons
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2019-01-24
DC.identifier	https://doi.org/10.1002/jbm.a.36619
DC.description	Lee S., Matsugaki A., Kasuga T., et al. Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation. Journal of Biomedical Materials Research - Part A, 107, 5, 1031. https://doi.org/10.1002/jbm.a.36619.
DCTERMS.abstract	During the bone regeneration process, the anisotropic microstructure of bone tissue (bone quality) recovers much later than bone mass (bone quantity), resulting in severe mechanical dysfunction in the bone. Hence, restoration of bone microstructure in parallel with bone mass is necessary for ideal bone tissue regeneration; for this, development of advanced bifunctional biomaterials, which control both the quality and quantity in regenerated bone, is required. We developed novel oriented bioactive glass/poly(lactic acid) composite scaffolds by introducing an effective methodology for controlling cell alignment and proliferation, which play important roles for achieving bone anisotropy and bone mass, respectively. Our strategy is to manipulate the cell alignment and proliferation by the morphological control of the scaffolds in combination with controlled ion release from bioactive glasses. We quantitatively controlled the morphology of fibermats containing bioactive glasses by electrospinning, which successfully induced cell alignment along the fibermats. Also, the substitution of CaO in Bioglass®(45S5) with MgO and SrO improved osteoblast proliferation, indicating that dissolved Mg 2+ and Sr 2+ ions promoted cell adhesion and proliferation. Our results indicate that the fibermats developed in this work are candidates for the scaffolds to bone tissue regeneration that enable recovery of both bone quality and bone quantity. © 2019 The Authors. journal Of Biomedical Materials Research Part A Published By Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1031–1041, 2019.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	89821
citation_title	Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation
citation_author	Lee, Sungho
	Matsugaki, Aira
	Kasuga, Toshihiro
	Nakano, Takayoshi
citation_publisher	John Wiley and Sons
citation_language	英語
citation_date	2019-01-24
citation_journal_title	Journal of Biomedical Materials Research - Part A
citation_volume	107
citation_issue	5
citation_firstpage	1031
citation_lastpage	1041
citation_doi	https://doi.org/10.1002/jbm.a.36619
citation_public_url	https://hdl.handle.net/11094/89821

Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation

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