Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation

Lee, Sungho; Kiyokane, Yuriko; Kasuga, Toshihiro; Nakano, Takayoshi

doi:https://doi.org/10.1080/21870764.2019.1599528

Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation

Lee, Sungho; Kiyokane, Yuriko; Kasuga, Toshihiro et al.

Journal of Asian Ceramic Societies, 2019, 7(2), 228-237

アクセス数:102件（2025-04-03 21:43 集計）

固定URL: https://hdl.handle.net/11094/89824

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
JAsianCeramSoc_7_2_228	pdf	なし	2.43 MB	61	2022.12.26

Creative Commons : 表示 - 非営利

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation
著者	NRID 1000020850001 1000020850001 著者名 Lee, Sungho
	著者名 Kiyokane, Yuriko
	NRID 1000030233729 1000030233729 著者名 Kasuga, Toshihiro
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
キーワード等	Biomaterial
	bone anisotropy
	bone quality
	electrospinning
	vaterite
内容	Lee S., Kiyokane Y., Kasuga T., et al. Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation. Journal of Asian Ceramic Societies, 7, 2, 228. https://doi.org/10.1080/21870764.2019.1599528.
抄録	Bone tissue has an anisotropic structure, which is strongly associated with the collagen fibril orientation and the direction of the c-axis of the bone apatite crystal. The bone regeneration process contains two main phases: bone mineral density (BMD; bone quantity) restoration and reconstruction of the bone apatite c-axis orientation (bone quality), which is the dominant factor for the mechanical properties of bone. Hence, restoration of the bone quality and quantity is required for bone tissue regeneration. In this work, novel, oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds were developed by controlling the cell alignment and proliferation, which play an important role in regenerating the bone quality and quantity, respectively. Our strategy controlled the cell alignment and proliferation using a morphological design of the scaffolds and the ions released from the siloxane-containing vaterite. The scaffolds were designed to control of the cell alignment, which successfully induced cell orientation along the fibermats. In addition, the released ions from the siloxane-containing vaterite improved osteoblast proliferation, indicating that the released Mg 2+ and silicate ions stimulated cell adhesion and proliferation. These results indicated that the fibermats developed in this work could be used for bone tissue regeneration scaffolds that enable the recovery of bone quality and quantity.
出版者	Taylor and Francis
収録物名	Journal of Asian Ceramic Societies
巻(号)	7(2)
ページ	228-237
刊行年月	2019-04-04
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89824
eISSN	21870764
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1080/21870764.2019.1599528
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Asian Ceramic Societies. 2019, 7(2), p. 228-237
DC.title	Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation
DC.creator	Lee, Sungho
	Kiyokane, Yuriko
	Kasuga, Toshihiro
	Nakano, Takayoshi
DC.publisher	Taylor and Francis
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2019-04-04
DC.identifier	https://doi.org/10.1080/21870764.2019.1599528
DC.subject	Biomaterial
	bone anisotropy
	bone quality
	electrospinning
	vaterite
DC.description	Lee S., Kiyokane Y., Kasuga T., et al. Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation. Journal of Asian Ceramic Societies, 7, 2, 228. https://doi.org/10.1080/21870764.2019.1599528.
DCTERMS.abstract	Bone tissue has an anisotropic structure, which is strongly associated with the collagen fibril orientation and the direction of the c-axis of the bone apatite crystal. The bone regeneration process contains two main phases: bone mineral density (BMD; bone quantity) restoration and reconstruction of the bone apatite c-axis orientation (bone quality), which is the dominant factor for the mechanical properties of bone. Hence, restoration of the bone quality and quantity is required for bone tissue regeneration. In this work, novel, oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds were developed by controlling the cell alignment and proliferation, which play an important role in regenerating the bone quality and quantity, respectively. Our strategy controlled the cell alignment and proliferation using a morphological design of the scaffolds and the ions released from the siloxane-containing vaterite. The scaffolds were designed to control of the cell alignment, which successfully induced cell orientation along the fibermats. In addition, the released ions from the siloxane-containing vaterite improved osteoblast proliferation, indicating that the released Mg 2+ and silicate ions stimulated cell adhesion and proliferation. These results indicated that the fibermats developed in this work could be used for bone tissue regeneration scaffolds that enable the recovery of bone quality and quantity.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	89824
citation_title	Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation
citation_author	Lee, Sungho
	Kiyokane, Yuriko
	Kasuga, Toshihiro
	Nakano, Takayoshi
citation_publisher	Taylor and Francis
citation_language	英語
citation_date	2019-04-04
citation_journal_title	Journal of Asian Ceramic Societies
citation_volume	7
citation_issue	2
citation_firstpage	228
citation_lastpage	237
citation_doi	https://doi.org/10.1080/21870764.2019.1599528
citation_public_url	https://hdl.handle.net/11094/89824

Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation

閲覧可能ファイル

論文情報

論文詳細を表示