Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone

Matsugaki, Aira; Harada, Tatsuki; Kimura, Yumi; Sekita, Aiko; Nakano, Takayoshi

doi:https://doi.org/10.3390/ijms19113474

Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone

Matsugaki, Aira; Harada, Tatsuki; Kimura, Yumi et al.

International Journal of Molecular Sciences, 2018, 19(11), 3474

アクセス数:133件（2025-04-03 22:21 集計）

固定URL: https://hdl.handle.net/11094/89828

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タイトル	Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone
著者	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 著者名 Matsugaki, Aira
	著者名 Harada, Tatsuki
	著者名 Kimura, Yumi
	著者名 Sekita, Aiko
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
キーワード等	Bone metastasis
	Bone microstructure
	Cell arrangement
	Collagen/apatite
内容	Matsugaki A., Harada T., Kimura Y., et al. Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone. International Journal of Molecular Sciences, 19, 11, 3474. https://doi.org/10.3390/ijms19113474.
抄録	Bone metastasis is one of the most intractable bone diseases; it is accompanied with a severe mechanical dysfunction of bone tissue. We recently discovered that the disorganized collagen/apatite microstructure in cancer-bearing bone is a dominant determinant of the disruption of bone mechanical function; disordered osteoblast arrangement was found to be one of the principal determinants of the deteriorated collagen/apatite microstructure. However, the precise molecular mechanisms regulating the disordered osteoblast arrangement triggered by cancer invasion are not yet understood. Herein, we demonstrate a significant disorganization of bone tissue anisotropy in metastasized bone in our novel ex vivo metastasis model. Further, we propose a novel mechanism underlying the disorganization of a metastasized bone matrix: A dynamic collision behavior between tumor cells and osteoblasts disturbs the osteoblast arrangement along the collagen substrate.
出版者	MDPI
収録物名	International Journal of Molecular Sciences
巻(号)	19(11)
ページ	3474
刊行年月	2018-11-05
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89828
PISSN	16616596
eISSN	14220067
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.3390/ijms19113474
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	International Journal of Molecular Sciences. 2018, 19(11), p. 3474
DC.title	Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone
DC.creator	Matsugaki, Aira
	Harada, Tatsuki
	Kimura, Yumi
	Sekita, Aiko
	Nakano, Takayoshi
DC.publisher	MDPI
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2018-11-05
DC.identifier	https://doi.org/10.3390/ijms19113474
DC.subject	Bone metastasis
	Bone microstructure
	Cell arrangement
	Collagen/apatite
DC.description	Matsugaki A., Harada T., Kimura Y., et al. Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone. International Journal of Molecular Sciences, 19, 11, 3474. https://doi.org/10.3390/ijms19113474.
DCTERMS.abstract	Bone metastasis is one of the most intractable bone diseases; it is accompanied with a severe mechanical dysfunction of bone tissue. We recently discovered that the disorganized collagen/apatite microstructure in cancer-bearing bone is a dominant determinant of the disruption of bone mechanical function; disordered osteoblast arrangement was found to be one of the principal determinants of the deteriorated collagen/apatite microstructure. However, the precise molecular mechanisms regulating the disordered osteoblast arrangement triggered by cancer invasion are not yet understood. Herein, we demonstrate a significant disorganization of bone tissue anisotropy in metastasized bone in our novel ex vivo metastasis model. Further, we propose a novel mechanism underlying the disorganization of a metastasized bone matrix: A dynamic collision behavior between tumor cells and osteoblasts disturbs the osteoblast arrangement along the collagen substrate.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89828
citation_title	Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone
citation_author	Matsugaki, Aira
	Harada, Tatsuki
	Kimura, Yumi
	Sekita, Aiko
	Nakano, Takayoshi
citation_publisher	MDPI
citation_language	英語
citation_date	2018-11-05
citation_journal_title	International Journal of Molecular Sciences
citation_volume	19
citation_issue	11
citation_firstpage	3474
citation_doi	https://doi.org/10.3390/ijms19113474
citation_public_url	https://hdl.handle.net/11094/89828

Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone

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