Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine

Ishimoto, Takuya; Yamada, Katsuhisa; Takahashi, Hiroyuki; Takahata, Masahiko; Ito, Manabu; Hanawa, Takao; Nakano, Takayoshi

doi:https://doi.org/10.1016/j.bone.2017.12.012

Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine

Ishimoto, Takuya; Yamada, Katsuhisa; Takahashi, Hiroyuki et al.

Bone, 2018, 108, 25-33

アクセス数:152件（2025-04-03 21:43 集計）

固定URL: https://hdl.handle.net/11094/89831

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タイトル	Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine
著者	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 著者名 Ishimoto, Takuya
	NRID 1000020771893 1000020771893 著者名 Yamada, Katsuhisa
	著者名 Takahashi, Hiroyuki
	NRID 1000040374368 1000040374368 著者名 Takahata, Masahiko
	NRID 1000000271677 1000000271677 著者名 Ito, Manabu
	NRID 1000090142736 1000090142736 著者名 Hanawa, Takao
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
キーワード等	Anisotropy
	Collagen/apatite orientation
	Fabric ellipse
	Intervertebral fusion cage
	Spine
	Trabecular architecture
内容	Ishimoto T., Yamada K., Takahashi H., et al. Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine. Bone, 108, 25. https://doi.org/10.1016/j.bone.2017.12.012.
抄録	Healthy trabecular bone shows highly anisotropic trabecular architecture and the preferential orientation of collagen and apatite inside a trabecula, both of which are predominantly directed along the cephalocaudal axis. This makes trabecular bone stiff in the principally loaded direction (cephalocaudal axis). However, changes in these anisotropic trabecular characteristics after the insertion of implant devices remain unclear. We defined the trabecular architectural anisotropy and the preferential orientation of collagen and apatite as parameters of trabecular bone health. In the present study, we analyzed these parameters after the implantation of two types of intervertebral fusion cages, open and closed box-type cages, into sheep spines for 2 and 4 months. Alteration and evolution of trabecular health around and inside the cages depended on the cage type and implantation duration. At the boundary region, the values of trabecular architectural anisotropy and apatite orientation for the closed-type cages were similar to those for isotropic conditions. In contrast, significantly larger anisotropy was found for open-type cages, indicating that the open-type cage tended to maintain trabecular anisotropy. Inside the open-type cage, trabecular architectural anisotropy and apatite orientation significantly increased with time after implantation. Assessing trabecular anisotropy might be useful for the evaluation of trabecular health and the validation and refinement of implant designs.
出版者	Elsevier
収録物名	Bone
巻(号)	108
ページ	25-33
刊行年月	2018-03-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89831
PISSN	87563282
NCID	AA10506985
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.bone.2017.12.012
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Bone. 2018, 108, p. 25-33
DC.title	Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine
DC.creator	Ishimoto, Takuya
	Yamada, Katsuhisa
	Takahashi, Hiroyuki
	Takahata, Masahiko
	Ito, Manabu
	Hanawa, Takao
	Nakano, Takayoshi
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2018-03-01
DC.identifier	https://doi.org/10.1016/j.bone.2017.12.012
DC.subject	Anisotropy
	Collagen/apatite orientation
	Fabric ellipse
	Intervertebral fusion cage
	Spine
	Trabecular architecture
DC.description	Ishimoto T., Yamada K., Takahashi H., et al. Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine. Bone, 108, 25. https://doi.org/10.1016/j.bone.2017.12.012.
DCTERMS.abstract	Healthy trabecular bone shows highly anisotropic trabecular architecture and the preferential orientation of collagen and apatite inside a trabecula, both of which are predominantly directed along the cephalocaudal axis. This makes trabecular bone stiff in the principally loaded direction (cephalocaudal axis). However, changes in these anisotropic trabecular characteristics after the insertion of implant devices remain unclear. We defined the trabecular architectural anisotropy and the preferential orientation of collagen and apatite as parameters of trabecular bone health. In the present study, we analyzed these parameters after the implantation of two types of intervertebral fusion cages, open and closed box-type cages, into sheep spines for 2 and 4 months. Alteration and evolution of trabecular health around and inside the cages depended on the cage type and implantation duration. At the boundary region, the values of trabecular architectural anisotropy and apatite orientation for the closed-type cages were similar to those for isotropic conditions. In contrast, significantly larger anisotropy was found for open-type cages, indicating that the open-type cage tended to maintain trabecular anisotropy. Inside the open-type cage, trabecular architectural anisotropy and apatite orientation significantly increased with time after implantation. Assessing trabecular anisotropy might be useful for the evaluation of trabecular health and the validation and refinement of implant designs.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89831
citation_title	Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine
citation_author	Ishimoto, Takuya
	Yamada, Katsuhisa
	Takahashi, Hiroyuki
	Takahata, Masahiko
	Ito, Manabu
	Hanawa, Takao
	Nakano, Takayoshi
citation_publisher	Elsevier
citation_language	英語
citation_date	2018-03-01
citation_journal_title	Bone
citation_volume	108
citation_firstpage	25
citation_lastpage	33
citation_doi	https://doi.org/10.1016/j.bone.2017.12.012
citation_public_url	https://hdl.handle.net/11094/89831

Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine

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