Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment

Sakanaka, Akito; Katakami, Naoto; Furuno, Masahiro; Nishizawa, Hitoshi; Omori, Kazuo; Taya, Naohiro; Ishikawa, Asuka; Mayumi, Shota; Inoue, Moe; Isomura, Emiko; Amano, Atsuo; Shimomura, Iichiro; Fukusaki, Eiichiro; Kuboniwa, Masae

doi:https://doi.org/10.3389/fmolb.2022.1074285

Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment

Sakanaka, Akito; Katakami, Naoto; Furuno, Masahiro et al.

Frontiers in Molecular Biosciences, 2022, 9, 1074285

アクセス数:2,121件（2025-07-27 19:06 集計）

固定URL: https://hdl.handle.net/11094/89884

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タイトル	Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment
著者	NRID 1000090815557 1000090815557 researchmap permalink sknk1022 sknk1022 Scopus Author ID 56814868300 56814868300 ORCID 0000-0001-9733-6886 0000-0001-9733-6886 著者名 Sakanaka, Akito
	NRID 1000010403049 1000010403049 researchmap permalink naoto.katakami naoto.katakami Scopus Author ID 7003392840 7003392840 著者名 Katakami, Naoto
	著者名 Furuno, Masahiro
	NRID 1000020379259 1000020379259 researchmap permalink Hitoshi_Nishizawa Hitoshi_Nishizawa Scopus Author ID 7102282682 7102282682 著者名 Nishizawa, Hitoshi
	著者名 Omori, Kazuo
	著者名 Taya, Naohiro
	著者名 Ishikawa, Asuka
	NRID 1000010964851 1000010964851 著者名 Mayumi, Shota
	著者名 Inoue, Moe
	NRID 1000070397701 1000070397701 researchmap permalink read0076452 read0076452 Scopus Author ID 55667115400 55667115400 著者名 Isomura, Emiko 著者の別表記 Tanaka, Emiko
	NRID 1000050193024 1000050193024 researchmap permalink read0014208 read0014208 Scopus Author ID 7101649822 7101649822 著者名 Amano, Atsuo
	NRID 1000060346145 1000060346145 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 著者名 Shimomura, Iichiro
	NRID 1000040273594 1000040273594 ORCID 0000-0003-3069-5547 0000-0003-3069-5547 researchmap permalink fukusaki-eiichiro fukusaki-eiichiro Scopus Author ID 35473325000 35473325000 著者名 Fukusaki, Eiichiro
	NRID 1000000303983 1000000303983 ORCID 0000-0002-3332-2431 0000-0002-3332-2431 researchmap permalink MasaeKuboniwa_URL MasaeKuboniwa_URL Scopus Author ID 56089471500 56089471500 著者名 Kuboniwa, Masae
キーワード等	atherosclerosis
	carotid intima-media thickness (IMT)
	diabetes
	metabolomics
	oxidative stress
	saliva
内容	Sakanaka A, Katakami N, Furuno M, Nishizawa H, Omori K, Taya N, Ishikawa A, Mayumi S, Inoue M, Tanaka Isomura E, Amano A, Shimomura I, Fukusaki E and Kuboniwa M (2022) Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment. Front. Mol. Biosci. 9:1074285. doi: 10.3389/fmolb.2022.1074285
抄録	Atherosclerosis is a life-threatening disease associated with morbidity and mortality in patients with type 2 diabetes (T2D). This study aimed to characterize a salivary signature of atherosclerosis based on evaluation of carotid intima-media thickness (IMT) to develop a non-invasive predictive tool for diagnosis and disease follow-up. Metabolites in saliva and plasma samples collected at admission and after treatment from 25 T2D patients hospitalized for 2 weeks to undergo medical treatment for diabetes were comprehensively profiled using metabolomic profiling with gas chromatography-mass spectrometry. Orthogonal partial least squares analysis, used to explore the relationships of IMT with clinical markers and plasma and salivary metabolites, showed that the top predictors for IMT included salivary allantoin and 1,5-anhydroglucitol (1,5-AG) at both the baseline examination at admission and after treatment. Furthermore, though treatment induced alterations in salivary levels of allantoin and 1,5-AG, it did not modify the association between IMT and these metabolites (pinteraction > 0.05), and models with these metabolites combined yielded satisfactory diagnostic accuracy for the high IMT group even after treatment (area under curve = 0.819). Collectively, this salivary metabolite combination may be useful for non-invasive identification of T2D patients with a higher atherosclerotic burden in clinical settings.
出版者	Frontiers Media
収録物名	Frontiers in Molecular Biosciences
巻(号)	9
ページ	1074285
刊行年月	2022-12-21
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89884
eISSN	2296889X
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.3389/fmolb.2022.1074285
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Frontiers in Molecular Biosciences. 2022, 9, p. 1074285
DC.title	Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment
DC.creator	Sakanaka, Akito
	Katakami, Naoto
	Furuno, Masahiro
	Nishizawa, Hitoshi
	Omori, Kazuo
	Taya, Naohiro
	Ishikawa, Asuka
	Mayumi, Shota
	Inoue, Moe
	Isomura, Emiko
	Amano, Atsuo
	Shimomura, Iichiro
	Fukusaki, Eiichiro
	Kuboniwa, Masae
DC.creator	Tanaka, Emiko
DC.publisher	Frontiers Media
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-12-21
DC.identifier	https://doi.org/10.3389/fmolb.2022.1074285
DC.subject	atherosclerosis
	carotid intima-media thickness (IMT)
	diabetes
	metabolomics
	oxidative stress
	saliva
DC.description	Sakanaka A, Katakami N, Furuno M, Nishizawa H, Omori K, Taya N, Ishikawa A, Mayumi S, Inoue M, Tanaka Isomura E, Amano A, Shimomura I, Fukusaki E and Kuboniwa M (2022) Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment. Front. Mol. Biosci. 9:1074285. doi: 10.3389/fmolb.2022.1074285
DCTERMS.abstract	Atherosclerosis is a life-threatening disease associated with morbidity and mortality in patients with type 2 diabetes (T2D). This study aimed to characterize a salivary signature of atherosclerosis based on evaluation of carotid intima-media thickness (IMT) to develop a non-invasive predictive tool for diagnosis and disease follow-up. Metabolites in saliva and plasma samples collected at admission and after treatment from 25 T2D patients hospitalized for 2 weeks to undergo medical treatment for diabetes were comprehensively profiled using metabolomic profiling with gas chromatography-mass spectrometry. Orthogonal partial least squares analysis, used to explore the relationships of IMT with clinical markers and plasma and salivary metabolites, showed that the top predictors for IMT included salivary allantoin and 1,5-anhydroglucitol (1,5-AG) at both the baseline examination at admission and after treatment. Furthermore, though treatment induced alterations in salivary levels of allantoin and 1,5-AG, it did not modify the association between IMT and these metabolites (pinteraction > 0.05), and models with these metabolites combined yielded satisfactory diagnostic accuracy for the high IMT group even after treatment (area under curve = 0.819). Collectively, this salivary metabolite combination may be useful for non-invasive identification of T2D patients with a higher atherosclerotic burden in clinical settings.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89884
citation_title	Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment
citation_author	Sakanaka, Akito
	Katakami, Naoto
	Furuno, Masahiro
	Nishizawa, Hitoshi
	Omori, Kazuo
	Taya, Naohiro
	Ishikawa, Asuka
	Mayumi, Shota
	Inoue, Moe
	Isomura, Emiko
	Amano, Atsuo
	Shimomura, Iichiro
	Fukusaki, Eiichiro
	Kuboniwa, Masae
citation_publisher	Frontiers Media
citation_language	英語
citation_date	2022-12-21
citation_journal_title	Frontiers in Molecular Biosciences
citation_volume	9
citation_firstpage	1074285
citation_doi	https://doi.org/10.3389/fmolb.2022.1074285
citation_public_url	https://hdl.handle.net/11094/89884

Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment

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