Antibacterial Properties and Biocompatibility of Hydroxyapatite Coating Doped with Various Cu Contents on Titanium

Li, Qiang; Song, Shihong; Li, Junjie; Yang, Jinshuai; Zhang, Ran; Niinomi, Mitsuo; Nakano, Takayoshi

doi:https://doi.org/10.2320/matertrans.MT-M2021245

Antibacterial Properties and Biocompatibility of Hydroxyapatite Coating Doped with Various Cu Contents on Titanium

Li, Qiang; Song, Shihong; Li, Junjie et al.

Materials Transactions, 2022, 63(7), 1072-1079

アクセス数:145件（2025-04-03 22:04 集計）

固定URL: https://hdl.handle.net/11094/89888

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タイトル	Antibacterial Properties and Biocompatibility of Hydroxyapatite Coating Doped with Various Cu Contents on Titanium
著者	著者名 Li, Qiang
	著者名 Song, Shihong
	著者名 Li, Junjie
	著者名 Yang, Jinshuai
	著者名 Zhang, Ran
	NRID 1000050126942 1000050126942 著者名 Niinomi, Mitsuo
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
キーワード等	antibacterial coating
	biocompatibility
	copper
	hydroxyapatite
	orthogonal experiment
内容	Li Q., Song S., Li J., et al. Antibacterial Properties and Biocompatibility of Hydroxyapatite Coating Doped with Various Cu Contents on Titanium. Materials Transactions 63, 1072 (2022); https://doi.org/10.2320/matertrans.MT-M2021245.
抄録	To explore the effect of copper content in a copper-doped hydroxyapatite coating (CuHAp) on its antibacterial activity and biocompatibility, a layer of CuHAp was deposited on the surface of pure Ti using an electrochemical deposition method. An orthogonal experiment was used to determine the Cu content in the coating by varying the concentration of Cu2+ in the electrolyte. The antibacterial properties and biocompatibility of the CuHAp coatings were also evaluated. The antibacterial effect increased with increasing Cu content in the sample. When the content of Cu in the coating was 1.57%, the deposited CuHAp coating exhibited excellent biocompatibility, and the number of living cells after culturing was significantly higher than that for the HAp coating. When the content of Cu increased to 6.85%, the coating exhibited cytotoxicity. Thus, the CuHAp sample with a Cu content of 1.57% exhibited good antibacterial and biocompatibility, and thus could be a suitable material for use in biomedical applications.
出版者	The Japan Institute of Metals and Materials
収録物名	Materials Transactions
巻(号)	63(7)
ページ	1072-1079
刊行年月	2022-07-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89888
PISSN	13459678
eISSN	13475320
NCID	AA1151294X
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.2320/matertrans.MT-M2021245
アクセス権	open access
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Materials Transactions. 2022, 63(7), p. 1072-1079
DC.title	Antibacterial Properties and Biocompatibility of Hydroxyapatite Coating Doped with Various Cu Contents on Titanium
DC.creator	Li, Qiang
	Song, Shihong
	Li, Junjie
	Yang, Jinshuai
	Zhang, Ran
	Niinomi, Mitsuo
	Nakano, Takayoshi
DC.publisher	The Japan Institute of Metals and Materials
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-07-01
DC.identifier	https://doi.org/10.2320/matertrans.MT-M2021245
DC.subject	antibacterial coating
	biocompatibility
	copper
	hydroxyapatite
	orthogonal experiment
DC.description	Li Q., Song S., Li J., et al. Antibacterial Properties and Biocompatibility of Hydroxyapatite Coating Doped with Various Cu Contents on Titanium. Materials Transactions 63, 1072 (2022); https://doi.org/10.2320/matertrans.MT-M2021245.
DCTERMS.abstract	To explore the effect of copper content in a copper-doped hydroxyapatite coating (CuHAp) on its antibacterial activity and biocompatibility, a layer of CuHAp was deposited on the surface of pure Ti using an electrochemical deposition method. An orthogonal experiment was used to determine the Cu content in the coating by varying the concentration of Cu2+ in the electrolyte. The antibacterial properties and biocompatibility of the CuHAp coatings were also evaluated. The antibacterial effect increased with increasing Cu content in the sample. When the content of Cu in the coating was 1.57%, the deposited CuHAp coating exhibited excellent biocompatibility, and the number of living cells after culturing was significantly higher than that for the HAp coating. When the content of Cu increased to 6.85%, the coating exhibited cytotoxicity. Thus, the CuHAp sample with a Cu content of 1.57% exhibited good antibacterial and biocompatibility, and thus could be a suitable material for use in biomedical applications.
DC.format	89888
citation_title	Antibacterial Properties and Biocompatibility of Hydroxyapatite Coating Doped with Various Cu Contents on Titanium
citation_author	Li, Qiang
	Song, Shihong
	Li, Junjie
	Yang, Jinshuai
	Zhang, Ran
	Niinomi, Mitsuo
	Nakano, Takayoshi
citation_publisher	The Japan Institute of Metals and Materials
citation_language	英語
citation_date	2022-07-01
citation_journal_title	Materials Transactions
citation_volume	63
citation_issue	7
citation_firstpage	1072
citation_lastpage	1079
citation_doi	https://doi.org/10.2320/matertrans.MT-M2021245
citation_public_url	https://hdl.handle.net/11094/89888

Antibacterial Properties and Biocompatibility of Hydroxyapatite Coating Doped with Various Cu Contents on Titanium

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