Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti

Yang, Jiawei; Li, Qiang; Li, Junjie; Yang, Jinshuai; Zhang, Ran; Niinomi, Mitsuo; Nakano, Takayoshi

doi:https://doi.org/10.1007/s11665-022-07541-6

Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti

Yang, Jiawei; Li, Qiang; Li, Junjie et al.

Journal of Materials Engineering and Performance, 2022, 32(14), 6151-6159

アクセス数:142件（2025-04-03 21:27 集計）

固定URL: https://hdl.handle.net/11094/89906

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タイトル	Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti
著者	著者名 Yang, Jiawei
	著者名 Li, Qiang
	著者名 Li, Junjie
	著者名 Yang, Jinshuai
	著者名 Zhang, Ran
	NRID 1000050126942 1000050126942 著者名 Niinomi, Mitsuo
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
キーワード等	adhesion
	antibacterial properties
	Cu-doped hydroxyapatite coating
	electrochemical deposition
	TiO₂ nanopore
内容	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11665-022-07541-6.
抄録	Cu-doped hydroxyapatite (HA)/TiO₂ (CuHA/TiO₂) bioactive ceramic composite coatings were prepared on Ti surfaces using an electrochemical method to enhance their adhesion and antibacterial properties. The obtained coatings were characterized by scanning electron microscopy, x-ray diffraction, and x-ray photoelectron spectroscopy, while their adhesion was measured using a scratch test. The maximum adhesion between the TiO₂ layer and the substrate was 39.8 ± 2.6 N at an anodizing voltage of 180 V. Subsequently, the CuHA coatings were successfully deposited on the TiO₂ layers and grown outward along TiO₂ pores (during this process, Cu atoms are doped into the HA structure in the form of Cu²⁺ ions). The CuHA adhesion to the TiO₂ layer was 26.3 ± 1.9 N, indicating that the TiO₂ interlayer significantly enhanced the bonding of CuHA to the substrate. Furthermore, the fabricated CuHA/TiO₂ coatings produced a strong antibacterial effect on Escherichia coli and Staphylococcus aureus species, exhibited high biocompatibility, and promoted the proliferation of MC₃T₃-E₁ cells.
出版者	Springer
収録物名	Journal of Materials Engineering and Performance
巻(号)	32(14)
ページ	6151-6159
刊行年月	2022-11-28
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89906
PISSN	10599495
eISSN	15441024
NCID	AA10850368
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1007/s11665-022-07541-6
アクセス権	open access
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Materials Engineering and Performance. 2022, 32(14), p. 6151-6159
DC.title	Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti
DC.creator	Yang, Jiawei
	Li, Qiang
	Li, Junjie
	Yang, Jinshuai
	Zhang, Ran
	Niinomi, Mitsuo
	Nakano, Takayoshi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-11-28
DC.identifier	https://doi.org/10.1007/s11665-022-07541-6
DC.subject	adhesion
	antibacterial properties
	Cu-doped hydroxyapatite coating
	electrochemical deposition
	TiO₂ nanopore
DC.description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11665-022-07541-6.
DCTERMS.abstract	Cu-doped hydroxyapatite (HA)/TiO₂ (CuHA/TiO₂) bioactive ceramic composite coatings were prepared on Ti surfaces using an electrochemical method to enhance their adhesion and antibacterial properties. The obtained coatings were characterized by scanning electron microscopy, x-ray diffraction, and x-ray photoelectron spectroscopy, while their adhesion was measured using a scratch test. The maximum adhesion between the TiO₂ layer and the substrate was 39.8 ± 2.6 N at an anodizing voltage of 180 V. Subsequently, the CuHA coatings were successfully deposited on the TiO₂ layers and grown outward along TiO₂ pores (during this process, Cu atoms are doped into the HA structure in the form of Cu²⁺ ions). The CuHA adhesion to the TiO₂ layer was 26.3 ± 1.9 N, indicating that the TiO₂ interlayer significantly enhanced the bonding of CuHA to the substrate. Furthermore, the fabricated CuHA/TiO₂ coatings produced a strong antibacterial effect on Escherichia coli and Staphylococcus aureus species, exhibited high biocompatibility, and promoted the proliferation of MC₃T₃-E₁ cells.
DC.format	89906
citation_title	Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti
citation_author	Yang, Jiawei
	Li, Qiang
	Li, Junjie
	Yang, Jinshuai
	Zhang, Ran
	Niinomi, Mitsuo
	Nakano, Takayoshi
citation_publisher	Springer
citation_language	英語
citation_date	2022-11-28
citation_journal_title	Journal of Materials Engineering and Performance
citation_volume	32
citation_issue	14
citation_firstpage	6151
citation_lastpage	6159
citation_doi	https://doi.org/10.1007/s11665-022-07541-6
citation_public_url	https://hdl.handle.net/11094/89906

Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti

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