Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases

Hashida, Noriyasu; Nishida, Kohji

doi:https://doi.org/10.1016/j.addr.2023.114870

Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases

Hashida, Noriyasu; Nishida, Kohji

Advanced Drug Delivery Reviews, 2023, 198, 114870

アクセス数:448件（2025-08-18 23:08 集計）

固定URL: https://hdl.handle.net/11094/91342

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タイトル	Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases
著者	NRID 1000030456959 1000030456959 researchmap permalink nh0814 nh0814 Scopus Author ID 6603280274 6603280274 著者名 Hashida, Noriyasu
著者	NRID 1000040244610 1000040244610 ORCID 0000-0001-9069-3610 0000-0001-9069-3610 researchmap permalink read0131487 read0131487 Scopus Author ID 57211973404 57211973404 著者名 Nishida, Kohji
キーワード等	Age-related macular degeneration
	Blood retinal barrier
	Clinical trial
	Diabetic retinopathy
	Drug delivery
	Retina
	Retinal vein occlusion
	Retinitis pigmentosa
	Vitreoretinal disease
	Vitreous
抄録	Effective drug therapy for vitreoretinal disease is a major challenge in the field of ophthalmology; various protective systems, including anatomical and physiological barriers, complicate drug delivery to precise targets. However, as the eye is a closed cavity, it is an ideal target for local administration. Various types of drug delivery systems have been investigated that take advantage of this aspect of the eye, enhancing ocular permeability and optimizing local drug concentrations. Many drugs, mainly anti-VEGF drugs, have been evaluated in clinical trials and have provided clinical benefit to many patients. In the near future, innovative drug delivery systems will be developed to avoid frequent intravitreal administration of drugs and maintain effective drug concentrations for a long period of time. Here, we review the published literature on various drugs and administration routes and current clinical applications. Recent advances in drug delivery systems are discussed along with future prospects.
出版者	Elsevier B.V.
収録物名	Advanced Drug Delivery Reviews
巻(号)	198
ページ	114870
刊行年月	2023-07-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/91342
PISSN	0169409X
eISSN	18728294
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1016/j.addr.2023.114870
アクセス権	open access
権利情報	© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Advanced Drug Delivery Reviews. 2023, 198, p. 114870
DC.title	Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases
DC.creator	Hashida, Noriyasu
DC.creator	Nishida, Kohji
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-07-01
DC.identifier	https://doi.org/10.1016/j.addr.2023.114870
DC.subject	Age-related macular degeneration
	Blood retinal barrier
	Clinical trial
	Diabetic retinopathy
	Drug delivery
	Retina
	Retinal vein occlusion
	Retinitis pigmentosa
	Vitreoretinal disease
	Vitreous
DCTERMS.abstract	Effective drug therapy for vitreoretinal disease is a major challenge in the field of ophthalmology; various protective systems, including anatomical and physiological barriers, complicate drug delivery to precise targets. However, as the eye is a closed cavity, it is an ideal target for local administration. Various types of drug delivery systems have been investigated that take advantage of this aspect of the eye, enhancing ocular permeability and optimizing local drug concentrations. Many drugs, mainly anti-VEGF drugs, have been evaluated in clinical trials and have provided clinical benefit to many patients. In the near future, innovative drug delivery systems will be developed to avoid frequent intravitreal administration of drugs and maintain effective drug concentrations for a long period of time. Here, we review the published literature on various drugs and administration routes and current clinical applications. Recent advances in drug delivery systems are discussed along with future prospects.
DC.rights	© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
DC.format	91342
citation_title	Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases
citation_author	Hashida, Noriyasu
citation_author	Nishida, Kohji
citation_publisher	Elsevier B.V.
citation_language	英語
citation_date	2023-07-01
citation_journal_title	Advanced Drug Delivery Reviews
citation_volume	198
citation_firstpage	114870
citation_doi	https://doi.org/10.1016/j.addr.2023.114870
citation_public_url	https://hdl.handle.net/11094/91342

Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases

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