Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients

Maeda, Shusaku; Otani, Tomohiro; Yamada, Shigeki; Watanabe, Yoshiyuki; Ilik, Selin Yavuz; Wada, Shigeo

doi:https://doi.org/10.1016/j.jbiomech.2023.111671

Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients

Maeda, Shusaku; Otani, Tomohiro; Yamada, Shigeki et al.

Journal of Biomechanics, 2023, 156, 111671

アクセス数:769件（2025-08-16 04:49 集計）

固定URL: https://hdl.handle.net/11094/92339

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タイトル	Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients
著者	著者名 Maeda, Shusaku
	NRID 1000040778990 1000040778990 ORCID 0000-0002-6431-2703 0000-0002-6431-2703 researchmap permalink bigvalley bigvalley Scopus Author ID 55625962900 55625962900 著者名 Otani, Tomohiro
	NRID 1000040422969 1000040422969 著者名 Yamada, Shigeki
	NRID 1000020362733 1000020362733 著者名 Watanabe, Yoshiyuki
	著者名 Ilik, Selin Yavuz
	NRID 1000070240546 1000070240546 researchmap permalink shigeo41010 shigeo41010 Scopus Author ID 7401983636 7401983636 著者名 Wada, Shigeo
キーワード等	Brain ventricle
	Cerebrospinal fluid
	Computational fluid dynamics
	Flow mixing
	Magnetic resonance imaging
内容	Maeda S., Otani T., Yamada S., et al. Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients. Journal of Biomechanics 156, 111671 (2023); https://doi.org/10.1016/j.jbiomech.2023.111671.
抄録	Normal pressure hydrocephalus (NPH) is an intracranial disease characterized by an abnormal accumulation of cerebrospinal fluid (CSF) in brain ventricles within the normal range of intracranial pressure. Most NPH in aged patients is idiopathic (iNPH) and without any prior history of intracranial diseases. Although an abnormal increase of CSF stroke volume (hyper-dynamic CSF flow) in the aqueduct between the third and fourth ventricles has received much attention as a clinical evaluation index in iNPH patients, the biomechanical effects of this flow on iNPH pathophysiology are poorly understood. This study aimed to clarify the potential biomechanical effects of hyper-dynamic CSF flow through the aqueduct of iNPH patients using magnetic resonance imaging-based computational simulations. Ventricular geometries and CSF flow rates through aqueducts of 10 iNPH patients and 10 healthy control subjects were obtained from multimodal magnetic resonance images, and these CSF flow fields were simulated using computational fluid dynamics. As biomechanical factors, we evaluated wall shear stress on the ventricular wall and the extent of flow mixing, which potentially disturbs the CSF composition in each ventricle. The results showed that the relatively high CSF flow rate and large and irregular shapes of the aqueduct in iNPH resulted in large wall shear stresses localized in relatively narrow regions. Furthermore, the resulting CSF flow showed a stable cyclic motion in control subjects, whereas strong mixing during transport through the aqueduct was found in patients with iNPH. These findings provide further insights into the clinical and biomechanical correlates of NPH pathophysiology.
出版者	Elsevier
収録物名	Journal of Biomechanics
巻(号)	156
ページ	111671
刊行年月	2023-07
言語	英語
ハンドルURL	https://hdl.handle.net/11094/92339
PISSN	00219290
eISSN	18732380
NCID	AA00694200
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1016/j.jbiomech.2023.111671
権利情報	© 2023. This manuscript version is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
権利情報	The full-text file will be made open to the public on 14 June 2024 in accordance with the publisher's policy.
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Biomechanics. 2023, 156, p. 111671
DC.title	Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients
DC.creator	Maeda, Shusaku
	Otani, Tomohiro
	Yamada, Shigeki
	Watanabe, Yoshiyuki
	Ilik, Selin Yavuz
	Wada, Shigeo
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-07
DC.identifier	https://doi.org/10.1016/j.jbiomech.2023.111671
DC.subject	Brain ventricle
	Cerebrospinal fluid
	Computational fluid dynamics
	Flow mixing
	Magnetic resonance imaging
DC.description	Maeda S., Otani T., Yamada S., et al. Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients. Journal of Biomechanics 156, 111671 (2023); https://doi.org/10.1016/j.jbiomech.2023.111671.
DCTERMS.abstract	Normal pressure hydrocephalus (NPH) is an intracranial disease characterized by an abnormal accumulation of cerebrospinal fluid (CSF) in brain ventricles within the normal range of intracranial pressure. Most NPH in aged patients is idiopathic (iNPH) and without any prior history of intracranial diseases. Although an abnormal increase of CSF stroke volume (hyper-dynamic CSF flow) in the aqueduct between the third and fourth ventricles has received much attention as a clinical evaluation index in iNPH patients, the biomechanical effects of this flow on iNPH pathophysiology are poorly understood. This study aimed to clarify the potential biomechanical effects of hyper-dynamic CSF flow through the aqueduct of iNPH patients using magnetic resonance imaging-based computational simulations. Ventricular geometries and CSF flow rates through aqueducts of 10 iNPH patients and 10 healthy control subjects were obtained from multimodal magnetic resonance images, and these CSF flow fields were simulated using computational fluid dynamics. As biomechanical factors, we evaluated wall shear stress on the ventricular wall and the extent of flow mixing, which potentially disturbs the CSF composition in each ventricle. The results showed that the relatively high CSF flow rate and large and irregular shapes of the aqueduct in iNPH resulted in large wall shear stresses localized in relatively narrow regions. Furthermore, the resulting CSF flow showed a stable cyclic motion in control subjects, whereas strong mixing during transport through the aqueduct was found in patients with iNPH. These findings provide further insights into the clinical and biomechanical correlates of NPH pathophysiology.
DC.rights	© 2023. This manuscript version is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.rights	The full-text file will be made open to the public on 14 June 2024 in accordance with the publisher's policy.
DC.format	92339
citation_title	Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients
citation_author	Maeda, Shusaku
	Otani, Tomohiro
	Yamada, Shigeki
	Watanabe, Yoshiyuki
	Ilik, Selin Yavuz
	Wada, Shigeo
citation_publisher	Elsevier
citation_language	英語
citation_date	2023-07
citation_journal_title	Journal of Biomechanics
citation_volume	156
citation_firstpage	111671
citation_doi	https://doi.org/10.1016/j.jbiomech.2023.111671
citation_public_url	https://hdl.handle.net/11094/92339

Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients

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