Lithium carbonate accelerates the healing of apical periodontitis

Kagioka, Takumi; Itoh, Shousaku; Hue, Mai Thi et al.

Scientific Reports, 2023, 13, 7886

アクセス数:911件（2025-10-25 20:51 集計）

固定URL: https://hdl.handle.net/11094/92523

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タイトル
Lithium carbonate accelerates the healing of apical periodontitis
著者
著者名
Kagioka, Takumi
NRID
1000090360495 1000090360495
researchmap permalink
read0118561 read0118561
Scopus Author ID
7403114471 7403114471
著者名
Itoh, Shousaku
著者名
Hue, Mai Thi
NRID
1000040448105 1000040448105
ORCID
0000-0002-7182-4280 0000-0002-7182-4280
researchmap permalink
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Scopus Author ID
55323236000 55323236000
著者名
Abe, Makoto
NRID
1000040271027 1000040271027
researchmap permalink
read0185244 read0185244
Scopus Author ID
26021225700 26021225700
著者名
Hayashi, Mikako
内容
Kagioka T., Itoh S., Hue M.T., et al. Lithium carbonate accelerates the healing of apical periodontitis. Scientific Reports 13, 7886 (2023); https://doi.org/10.1038/s41598-023-34700-z.
抄録
Apical periodontitis is a disease caused by bacterial invasions through the root canals. Our previous study reported that lithium chloride (LiCl) had a healing effect on apical periodontitis. The aim of this report is to investigate the healing properties and mechanism of lithium ion (Li+) for apical periodontitis using rat root canal treatment model. 10-week-old male Wistar rat’s mandibular first molars with experimentally induced apical periodontitis underwent root canal treatment and were applied lithium carbonate (Li2CO3) containing intracanal medicament. Base material of the medicament was used as a control. Subject teeth were scanned by micro-CT every week and the periapical lesion volume was evaluated. The lesion volume of Li2CO3 group was significantly smaller than that of the control group. Histological analysis showed that in Li2CO3 group, M2 macrophages and regulatory T cells were induced in the periapical lesion. In situ hybridization experiments revealed a greater expression of Col1a1 in Li2CO3 group compared with the control group. At 24 h after application of intracanal medicament, Axin2-positive cells were distributed in Li2CO3 group. In conclusion, Li2CO3 stimulates Wnt/β-catenin signaling pathway and accelerate the healing process of apical periodontitis, modulating the immune system and the bone metabolism.
出版者
Nature Research
収録物名
Scientific Reports
巻(号)
13
ページ
7886
刊行年月
2023-05-16
言語
英語
ハンドルURL
https://hdl.handle.net/11094/92523
eISSN
20452322
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1038/s41598-023-34700-z
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article