Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji

Ebihara, Takeshi; Shimizu, Kentaro; Mitsuyama, Yumi; Ogura, Hiroshi; Oda, Jun

doi:https://doi.org/10.1186/s40101-023-00322-7

Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji

Ebihara, Takeshi; Shimizu, Kentaro; Mitsuyama, Yumi et al.

Journal of Physiological Anthropology, 2023, 42, 6

アクセス数:988件（2025-09-29 14:23 集計）

固定URL: https://hdl.handle.net/11094/92528

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タイトル	Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji
著者	NRID 1000010813975 1000010813975 ORCID 0000-0003-4101-0419 0000-0003-4101-0419 researchmap permalink ebihara830 ebihara830 著者名 Ebihara, Takeshi
	NRID 1000060379203 1000060379203 researchmap permalink kentaroshimizu kentaroshimizu Scopus Author ID 55303276200 55303276200 著者名 Shimizu, Kentaro
	著者名 Mitsuyama, Yumi
	NRID 1000070301265 1000070301265 researchmap permalink read0054647 read0054647 Scopus Author ID 7202495132 7202495132 著者名 Ogura, Hiroshi
	NRID 1000060459500 1000060459500 ORCID 0000-0002-8254-3716 0000-0002-8254-3716 researchmap permalink read0068529 read0068529 Scopus Author ID 56210537000 56210537000 著者名 Oda, Jun
キーワード等	Cardiac function
	Mt. Fuji
	Mt. Fuji research station
	Non-invasive hemodynamic monitor
内容	Ebihara T., Shimizu K., Mitsuyama Y., et al. Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji. Journal of Physiological Anthropology 42, 6 (2023); https://doi.org/10.1186/s40101-023-00322-7.
抄録	Background: Acute mountain sickness (AMS) affects around 30% of people climbing Mt. Fuji, but its pathogenesis is incompletely understood. The influence of a rapid ascent to high altitude by climbing and summiting Mt. Fuji on cardiac function in the general population is unknown, and its association with altitude sickness has not been clarified. Methods: Subjects climbing Mt. Fuji were included. Heart rate, oxygen saturation, systolic blood pressure, cardiac index (CI) and stroke volume index were measured multiple times at 120 m as baseline values and at Mt. Fuji Research Station (MFRS) at 3,775 m. Each value and its difference from the baseline value (Δ) of subjects with AMS (defined as Lake Louise Score [LLS] ≥ 3 with headache after sleeping at 3,775 m) were compared with those of non-AMS subjects. Results: Eleven volunteers who climbed from 2,380 m to MFRS within 8 h and stayed overnight at MFRS were included. Four suffered AMS. Compared with the non-AMS subjects, CI in the AMS subjects was significantly higher than that before sleeping (median [interquartile range]: 4.9 [4.5, 5.0] vs. 3.8 [3.4, 3.9] mL/min/m2; p = 0.04), and their ΔCI was significantly higher before sleeping (1.6 [1.4, 2.1] vs. 0.2 [0.0, 0.7] mL/min/m2; p < 0.01) and after sleeping (0.7 [0.3, 1.7] vs. -0.2 [-0.5, 0.0] mL/min/m2; p < 0.01). ΔCI in the AMS subjects dropped significantly after sleeping versus before sleeping (3.8 [3.6, 4.5] vs. 4.9 [4.5, 5.0] mL/min/m2; p = 0.04). Conclusions: Higher values of CI and ΔCI were observed at high altitude in the AMS subjects. A high cardiac output might be associated with the development of AMS.
出版者	BioMed Central Ltd
収録物名	Journal of Physiological Anthropology
巻(号)	42
ページ	6
刊行年月	2023-04-13
言語	英語
ハンドルURL	https://hdl.handle.net/11094/92528
PISSN	18806791
eISSN	18806805
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1186/s40101-023-00322-7
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Physiological Anthropology. 2023, 42, p. 6
DC.title	Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji
DC.creator	Ebihara, Takeshi
	Shimizu, Kentaro
	Mitsuyama, Yumi
	Ogura, Hiroshi
	Oda, Jun
DC.publisher	BioMed Central Ltd
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-04-13
DC.identifier	https://doi.org/10.1186/s40101-023-00322-7
DC.subject	Cardiac function
	Mt. Fuji
	Mt. Fuji research station
	Non-invasive hemodynamic monitor
DC.description	Ebihara T., Shimizu K., Mitsuyama Y., et al. Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji. Journal of Physiological Anthropology 42, 6 (2023); https://doi.org/10.1186/s40101-023-00322-7.
DCTERMS.abstract	Background: Acute mountain sickness (AMS) affects around 30% of people climbing Mt. Fuji, but its pathogenesis is incompletely understood. The influence of a rapid ascent to high altitude by climbing and summiting Mt. Fuji on cardiac function in the general population is unknown, and its association with altitude sickness has not been clarified. Methods: Subjects climbing Mt. Fuji were included. Heart rate, oxygen saturation, systolic blood pressure, cardiac index (CI) and stroke volume index were measured multiple times at 120 m as baseline values and at Mt. Fuji Research Station (MFRS) at 3,775 m. Each value and its difference from the baseline value (Δ) of subjects with AMS (defined as Lake Louise Score [LLS] ≥ 3 with headache after sleeping at 3,775 m) were compared with those of non-AMS subjects. Results: Eleven volunteers who climbed from 2,380 m to MFRS within 8 h and stayed overnight at MFRS were included. Four suffered AMS. Compared with the non-AMS subjects, CI in the AMS subjects was significantly higher than that before sleeping (median [interquartile range]: 4.9 [4.5, 5.0] vs. 3.8 [3.4, 3.9] mL/min/m2; p = 0.04), and their ΔCI was significantly higher before sleeping (1.6 [1.4, 2.1] vs. 0.2 [0.0, 0.7] mL/min/m2; p < 0.01) and after sleeping (0.7 [0.3, 1.7] vs. -0.2 [-0.5, 0.0] mL/min/m2; p < 0.01). ΔCI in the AMS subjects dropped significantly after sleeping versus before sleeping (3.8 [3.6, 4.5] vs. 4.9 [4.5, 5.0] mL/min/m2; p = 0.04). Conclusions: Higher values of CI and ΔCI were observed at high altitude in the AMS subjects. A high cardiac output might be associated with the development of AMS.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	92528
citation_title	Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji
citation_author	Ebihara, Takeshi
	Shimizu, Kentaro
	Mitsuyama, Yumi
	Ogura, Hiroshi
	Oda, Jun
citation_publisher	BioMed Central Ltd
citation_language	英語
citation_date	2023-04-13
citation_journal_title	Journal of Physiological Anthropology
citation_volume	42
citation_firstpage	6
citation_doi	https://doi.org/10.1186/s40101-023-00322-7
citation_public_url	https://hdl.handle.net/11094/92528

Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji

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