学術雑誌論文

学術雑誌論文

text

Chemical Science. 2022, 13(48), p. 14387-14394

anti-Selective synthesis of β-boryl-α-amino acid derivatives by Cu-catalysed borylamination of α,β-unsaturated esters

Royal Society of Chemistry

英語

text

2022-11-24

https://doi.org/10.1039/d2sc06003e

Nishino S., Nishii Y., Hirano K.. anti-Selective synthesis of β-boryl-α-amino acid derivatives by Cu-catalysed borylamination of α,β-unsaturated esters. Chemical Science 13, 14387 (2022); https://doi.org/10.1039/d2sc06003e.

A copper-catalysed regio- and diastereoselective borylamination of α,β-unsaturated esters with B2pin2 and hydroxylamines has been developed to deliver acyclic β-boryl-α-amino acid derivatives with high anti-diastereoselectivity (up to >99 : 1), which is difficult to obtain by the established methods. A chiral phosphoramidite ligand also successfully induces the enantioselectivity, giving the optically active β-borylated α-amino acids. The products can be stereospecifically transformed into β-functionalised α-amino acids, which are of potent interest in medicinal chemistry.

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

92608

anti-Selective synthesis of β-boryl-α-amino acid derivatives by Cu-catalysed borylamination of α,β-unsaturated esters

Royal Society of Chemistry

英語

2022-11-24

Chemical Science

13

48

14387

14394

https://doi.org/10.1039/d2sc06003e

https://hdl.handle.net/11094/92608