Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy

Hazra, Sunit; Hirano, Koji; Miura, Masahiro

Organic Letters, 2021, 23(4), 1388-1393

アクセス数:567件（2025-08-28 19:36 集計）

固定URL: https://hdl.handle.net/11094/92698

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タイトル
Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy
著者
著者名
Hazra, Sunit
NRID
1000070532696 1000070532696
ORCID
0000-0001-9752-1985 0000-0001-9752-1985
researchmap permalink
koj koj
Scopus Author ID
7402407063 7402407063
著者名
Hirano, Koji
NRID
1000020183626 1000020183626
ORCID
0000-0001-8288-6439 0000-0001-8288-6439
researchmap permalink
read0013936 read0013936
Scopus Author ID
7402799909 7402799909
著者名
Miura, Masahiro
内容
Hazra S., Hirano K., Miura M.. Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy. Organic Letters. 23(4), 1388-1393, (2021), 19 February 2021; © 2021 American Chemical Society. https://doi.org/10.1021/acs.orglett.1c00050.
抄録
A rhodium-catalyzed C4-selective C-H alkenylation of 3-carboxy-2-pyridones with styrenes has been developed. The carboxylic group at the C3 position works as the traceless directing group, and the corresponding C4-alkenylated 2-pyridones are obtained exclusively with concomitant decarboxylation. Unlike the reported procedures, the exclusive C4 selectivity is uniformly observed even in the presence of potentially more reactive C-H bonds at the C5 and C6 positions. By using this strategy, the multiply substituted 2-pyridone can be prepared via sequential C-H functionalization reactions.
出版者
American Chemical Society
収録物名
Organic Letters
巻(号)
23(4)
ページ
1388-1393
刊行年月
2021-02-19
言語
英語
ハンドルURL
https://hdl.handle.net/11094/92698
PISSN
15237060
eISSN
15237052
関連情報 (isVersionOf)
DOI (出版社版)
https://doi.org/10.1021/acs.orglett.1c00050
アクセス権
open access
権利情報
© 2021 American Chemical Society.
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in, Organic Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.1c00050.
出版タイプ
Accepted Manuscript
カテゴリ
学術雑誌論文 Journal Article