学術雑誌論文

学術雑誌論文

text

Organic Letters. 2021, 23(1), p. 49-53

Synthesis of Isothiazoles and Isoselenazoles through Rhodium-Catalyzed Oxidative Annulation with Elemental Sulfur and Selenium

American Chemical Society

英語

text

2021-01-01

https://doi.org/10.1021/acs.orglett.0c03674

Moon S., Nishii Y., Miura M.. Synthesis of Isothiazoles and Isoselenazoles through Rhodium-Catalyzed Oxidative Annulation with Elemental Sulfur and Selenium. Organic Letters. 23(1), 49-53, (2021), 1 January 2021; ©2021 American Chemical Society. https://doi.org/10.1021/acs.orglett.0c03674.

A rhodium-catalyzed oxidative annulation of benzimidates with elemental sulfur for the direct construction of isothi-azole rings is reported. The proposed reaction mechanism involving Rh(I)/Rh(III) redox is supported by a stoichiometric reaction of metallacycle species as well as DFT calculations. This method is also applicable to the selenium cyclization to produce isoselenazole derivatives. The alkoxy substituent at the C3 position can be used for further functionalization of the azole cores.

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.0c03674.

92812

Synthesis of Isothiazoles and Isoselenazoles through Rhodium-Catalyzed Oxidative Annulation with Elemental Sulfur and Selenium

American Chemical Society

英語

2021-01-01

Organic Letters

23

1

49

53

https://doi.org/10.1021/acs.orglett.0c03674

https://hdl.handle.net/11094/92812