学術雑誌論文

学術雑誌論文

text

International Journal of Molecular Sciences. 2023, 24(14), p. 11393

Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models

Multidisciplinary Digital Publishing Institute (MDPI)

英語

text

2023-07-13

https://doi.org/10.3390/ijms241411393

Tanaka K., Ohara S., Matsuzaka T., et al. Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models. International Journal of Molecular Sciences 24, 11393 (2023); https://doi.org/10.3390/ijms241411393.

The auditory brainstem response (ABR) is a scalp recording of potentials produced by sound stimulation, and is commonly used as an indicator of auditory function. However, the ABR threshold, which is the lowest audible sound pressure, cannot be objectively determined since it is determined visually using a measurer, and this has been a problem for several decades. Although various algorithms have been developed to objectively determine ABR thresholds, they remain lacking in terms of accuracy, efficiency, and convenience. Accordingly, we proposed an improved algorithm based on the mutual covariance at adjacent sound pressure levels. An ideal ABR waveform with clearly defined waves I–V was created; moreover, using this waveform as a standard template, the experimentally obtained ABR waveform was inspected for disturbances based on mutual covariance. The ABR testing was repeated if the value was below the established cross-covariance reference value. Our proposed method allowed more efficient objective determination of ABR thresholds and a smaller burden on experimental animals.

This article is licensed under a Creative Commons Attribution 4.0 International License.

93113

Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models

Multidisciplinary Digital Publishing Institute (MDPI)

英語

2023-07-13

International Journal of Molecular Sciences

24

14

11393

https://doi.org/10.3390/ijms241411393

https://hdl.handle.net/11094/93113