学術雑誌論文

学術雑誌論文

text

Nature Communications. 2022, 13(1), p. 1066

Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo

Nature Research

英語

text

2022-02-24

https://doi.org/10.1038/s41467-022-28673-2

Uenaka M., Yamashita E., Kikuta J., et al. Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo. Nature Communications 13, 1066 (2022); https://doi.org/10.1038/s41467-022-28673-2.

Bone metabolism is regulated by the cooperative activity between bone-forming osteoblasts and bone-resorbing osteoclasts. However, the mechanisms mediating the switch between the osteoblastic and osteoclastic phases have not been fully elucidated. Here, we identify a specific subset of mature osteoblast-derived extracellular vesicles that inhibit bone formation and enhance osteoclastogenesis. Intravital imaging reveals that mature osteoblasts secrete and capture extracellular vesicles, referred to as small osteoblast vesicles (SOVs). Co-culture experiments demonstrate that SOVs suppress osteoblast differentiation and enhance the expression of receptor activator of NF-κB ligand, thereby inducing osteoclast differentiation. We also elucidate that the SOV-enriched microRNA miR-143 inhibits Runt-related transcription factor 2, a master regulator of osteoblastogenesis, by targeting the mRNA expression of its dimerization partner, core-binding factor β. In summary, we identify SOVs as a mode of cell-to-cell communication, controlling the dynamic transition from bone-forming to bone-resorbing phases in vivo.

This article is licensed under a Creative Commons Attribution 4.0 International License.

93153

Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo

Nature Research

英語

2022-02-24

Nature Communications

13

1

1066

https://doi.org/10.1038/s41467-022-28673-2

https://hdl.handle.net/11094/93153