学術雑誌論文

学術雑誌論文

text

Biomolecules. 2021, 11(11), p. 1624

The effects of vitamin D on immune system and inflammatory diseases

MDPI

英語

text

2021-11-03

https://doi.org/10.3390/biom11111624

Ao T., Kikuta J., Ishii M.. The effects of vitamin D on immune system and inflammatory diseases. Biomolecules 11, 1624 (2021); https://doi.org/10.3390/biom11111624.

Immune cells, including dendritic cells, macrophages, and T and B cells, express the vitamin D receptor and 1α-hydroxylase. In vitro studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, has an anti-inflammatory effect. Recent epidemiological evidence has indicated a significant association between vitamin D deficiency and an increased incidence, or aggravation, of infectious diseases and inflammatory autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. However, the impact of vitamin D on treatment and prevention, particularly in infectious diseases such as the 2019 coronavirus disease (COVID-19), remains controversial. Here, we review recent evidence associated with the relationship between vitamin D and inflammatory diseases and describe the underlying immunomodulatory effect of vitamin D.

This article is licensed under a Creative Commons Attribution 4.0 International License.

93155

The effects of vitamin D on immune system and inflammatory diseases

MDPI

英語

2021-11-03

Biomolecules

11

11

1624

https://doi.org/10.3390/biom11111624

https://hdl.handle.net/11094/93155