Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions

Sudo, Takao; Motomura, Yasutaka; Okuzaki, Daisuke; Hasegawa, Tetsuo; Yokota, Takafumi; Kikuta, Junichi; Ao, Tomoka; Mizuno, Hiroki; Matsui, Takahiro; Motooka, Daisuke; Yoshizawa, Ryosuke; Nagasawa, Takashi; Kanakura, Yuzuru; Moro, Kazuyo; Ishii, Masaru

doi:https://doi.org/10.1084/jem.20200817

Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions

Sudo, Takao; Motomura, Yasutaka; Okuzaki, Daisuke et al.

Journal of Experimental Medicine, 2021, 218(5), e20200817

アクセス数:182件（2025-04-12 22:55 集計）

固定URL: https://hdl.handle.net/11094/93159

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タイトル	Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions
著者	NRID 1000080631184 1000080631184 researchmap permalink kik kik Scopus Author ID 36497716100 36497716100 著者名 Sudo, Takao
	NRID 1000010587794 1000010587794 ORCID 0000-0003-1088-9985 0000-0003-1088-9985 researchmap permalink yasutaka_motomura yasutaka_motomura Scopus Author ID 23036180600 23036180600 著者名 Motomura, Yasutaka
	NRID 1000000346131 1000000346131 ORCID 0000-0002-4552-783X 0000-0002-4552-783X researchmap permalink read0092307 read0092307 Scopus Author ID 6506703054 6506703054 著者名 Okuzaki, Daisuke
	NRID 1000030773048 1000030773048 著者名 Hasegawa, Tetsuo
	NRID 1000060403200 1000060403200 researchmap permalink 6000022404 6000022404 Scopus Author ID 7402558170 7402558170 著者名 Yokota, Takafumi
	NRID 1000060710069 1000060710069 researchmap permalink jkikuta jkikuta Scopus Author ID 36637603800 36637603800 著者名 Kikuta, Junichi
	NRID 1000090880865 1000090880865 researchmap permalink tomoka_ao1203 tomoka_ao1203 著者名 Ao, Tomoka
	NRID 1000090707655 1000090707655 著者名 Mizuno, Hiroki
	NRID 1000050747037 1000050747037 ORCID 0000-0002-6753-1688 0000-0002-6753-1688 researchmap permalink takahiromatsui takahiromatsui Scopus Author ID 35176152500 35176152500 著者名 Matsui, Takahiro
	NRID 1000010636830 1000010636830 researchmap permalink daisukem daisukem Scopus Author ID 35315737900 35315737900 著者名 Motooka, Daisuke
	著者名 Yoshizawa, Ryosuke
	NRID 1000080281690 1000080281690 ORCID 0000-0002-1085-0960 0000-0002-1085-0960 researchmap permalink read0094728 read0094728 Scopus Author ID 35196507500 35196507500 著者名 Nagasawa, Takashi
	NRID 1000020177489 1000020177489 著者名 Kanakura, Yuzuru
	NRID 1000090468489 1000090468489 ORCID 0000-0002-7377-1303 0000-0002-7377-1303 researchmap permalink kazuyomoro kazuyomoro Scopus Author ID 16638841900 16638841900 著者名 Moro, Kazuyo
	NRID 1000010324758 1000010324758 researchmap permalink read0076684 read0076684 Scopus Author ID 35074093500 35074093500 著者名 Ishii, Masaru
内容	Sudo T., Motomura Y., Okuzaki D., et al. Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. Journal of Experimental Medicine 218, e20200817 (2021); https://doi.org/10.1084/jem.20200817.
抄録	The cell-cycle status of hematopoietic stem and progenitor cells (HSPCs) becomes activated following chemotherapy-induced stress, promoting bone marrow (BM) regeneration; however, the underlying molecular mechanism remains elusive. Here we show that BM-resident group 2 innate lymphoid cells (ILC2s) support the recovery of HSPCs from 5-fluorouracil (5-FU)-induced stress by secreting granulocyte-macrophage colony-stimulating factor (GM-CSF). Mechanistically, IL-33 released from chemosensitive B cell progenitors activates MyD88-mediated secretion of GM-CSF in ILC2, suggesting the existence of a B cell-ILC2 axis for maintaining hematopoietic homeostasis. GM-CSF knockout mice treated with 5-FU showed severe loss of myeloid lineage cells, causing lethality, which was rescued by transferring BM ILC2s from wild-type mice. Further, the adoptive transfer of ILC2s to 5-FU-treated mice accelerates hematopoietic recovery, while the reduction of ILC2s results in the opposite effect. Thus, ILC2s may function by "sensing" the damaged BM spaces and subsequently support hematopoietic recovery under stress conditions.
出版者	Rockefeller University Press
収録物名	Journal of Experimental Medicine
巻(号)	218(5)
ページ	e20200817
刊行年月	2021-05-03
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93159
PISSN	00221007
eISSN	15409538
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1084/jem.20200817
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Experimental Medicine. 2021, 218(5), p. e20200817
DC.title	Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions
DC.creator	Sudo, Takao
	Motomura, Yasutaka
	Okuzaki, Daisuke
	Hasegawa, Tetsuo
	Yokota, Takafumi
	Kikuta, Junichi
	Ao, Tomoka
	Mizuno, Hiroki
	Matsui, Takahiro
	Motooka, Daisuke
	Yoshizawa, Ryosuke
	Nagasawa, Takashi
	Kanakura, Yuzuru
	Moro, Kazuyo
	Ishii, Masaru
DC.publisher	Rockefeller University Press
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-05-03
DC.identifier	https://doi.org/10.1084/jem.20200817
DC.description	Sudo T., Motomura Y., Okuzaki D., et al. Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. Journal of Experimental Medicine 218, e20200817 (2021); https://doi.org/10.1084/jem.20200817.
DCTERMS.abstract	The cell-cycle status of hematopoietic stem and progenitor cells (HSPCs) becomes activated following chemotherapy-induced stress, promoting bone marrow (BM) regeneration; however, the underlying molecular mechanism remains elusive. Here we show that BM-resident group 2 innate lymphoid cells (ILC2s) support the recovery of HSPCs from 5-fluorouracil (5-FU)-induced stress by secreting granulocyte-macrophage colony-stimulating factor (GM-CSF). Mechanistically, IL-33 released from chemosensitive B cell progenitors activates MyD88-mediated secretion of GM-CSF in ILC2, suggesting the existence of a B cell-ILC2 axis for maintaining hematopoietic homeostasis. GM-CSF knockout mice treated with 5-FU showed severe loss of myeloid lineage cells, causing lethality, which was rescued by transferring BM ILC2s from wild-type mice. Further, the adoptive transfer of ILC2s to 5-FU-treated mice accelerates hematopoietic recovery, while the reduction of ILC2s results in the opposite effect. Thus, ILC2s may function by "sensing" the damaged BM spaces and subsequently support hematopoietic recovery under stress conditions.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
DC.format	93159
citation_title	Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions
citation_author	Sudo, Takao
	Motomura, Yasutaka
	Okuzaki, Daisuke
	Hasegawa, Tetsuo
	Yokota, Takafumi
	Kikuta, Junichi
	Ao, Tomoka
	Mizuno, Hiroki
	Matsui, Takahiro
	Motooka, Daisuke
	Yoshizawa, Ryosuke
	Nagasawa, Takashi
	Kanakura, Yuzuru
	Moro, Kazuyo
	Ishii, Masaru
citation_publisher	Rockefeller University Press
citation_language	英語
citation_date	2021-05-03
citation_journal_title	Journal of Experimental Medicine
citation_volume	218
citation_issue	5
citation_firstpage	e20200817
citation_doi	https://doi.org/10.1084/jem.20200817
citation_public_url	https://hdl.handle.net/11094/93159

Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions

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