学術雑誌論文

学術雑誌論文

text

Crystals. 2021, 11(9), p. 1069

Growth of Acetaminophen Polymorphic Crystals and Solution-Mediated Phase Transition from Trihydrate to Form II in Agarose Gel

MDPI

英語

text

2021-09-05

https://doi.org/10.3390/cryst11091069

Nishigaki A., Maruyama M., Tanaka S.I., et al. Growth of acetaminophen polymorphic crystals and solution-mediated phase transition from trihydrate to form II in agarose gel. Crystals 11, 1069 (2021); https://doi.org/10.3390/cryst11091069.

The growth of acetaminophen polymorphic crystals and the solution-mediated phase transition from trihydrate to form II in agarose gel were investigated. The form II crystals grown in gels, presumably because of the agarose content, dissolved less rapidly at high temperatures and were more stable than in water. The trihydrate crystals in the gel were also expected to be stabilized by containing agarose, but in fact the fine morphology resulted in reduced stability. The solution-mediated phase transition from trihydrate to form II via form II seeding took longer in the gel because the gel slowed down the dissolution of the trihydrate by hindering the dispersion of the form II seeds and delayed the growth of form II by reducing the diffusion rate of the molecules dissolved from the trihydrate. Delays in solution-mediated phase transition and changes in stability for crystals grown in gels indicate the effectiveness of gels in controlling polymorphisms in pharmaceutical compounds.

This article is licensed under a Creative Commons Attribution 4.0 International License.

93289

Growth of Acetaminophen Polymorphic Crystals and Solution-Mediated Phase Transition from Trihydrate to Form II in Agarose Gel

MDPI

英語

2021-09-05

Crystals

11

9

1069

https://doi.org/10.3390/cryst11091069

https://hdl.handle.net/11094/93289