Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity

Abe, Kengo; Tsumaki, Noriyuki

Inflammation and Regeneration, 2023, 43(1), 56

アクセス数:208件（2025-08-14 20:04 集計）

固定URL: https://hdl.handle.net/11094/93294

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タイトル
Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity
著者
NRID
1000010983546 1000010983546
著者名
Abe, Kengo
NRID
1000050303938 1000050303938
ORCID
0000-0002-0520-3654 0000-0002-0520-3654
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Scopus Author ID
7004069586 7004069586
著者名
Tsumaki, Noriyuki
キーワード等
Allogeneic transplantation
Articular cartilage
Chondrocytes
Immune response
Induced pluripotent stem cells
内容
Abe K., Tsumaki N.. Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity. Inflammation and Regeneration 43, 56 (2023); https://doi.org/10.1186/s41232-023-00307-0.
抄録
Background: Because of its poor intrinsic repair capacity, articular cartilage seldom heals when damaged. Main body: Regenerative treatment is expected for the treatment of articular cartilage damage, and allogeneic chondrocytes or cartilage have an advantage over autologous chondrocytes, which are limited in number. However, the presence or absence of an immune response has not been analyzed and remains controversial. Allogeneic-induced pluripotent stem cell (iPSC)–derived cartilage, a new resource for cartilage regeneration, reportedly survived and integrated with native cartilage after transplantation into chondral defects in knee joints without immune rejection in a recent primate model. Here, we review and discuss the immunogenicity of chondrocytes and the efficacy of allogeneic cartilage transplantation, including iPSC-derived cartilage. Short conclusion: Allogeneic iPSC-derived cartilage transplantation, a new therapeutic option, could be a good indication for chondral defects, and the development of translational medical technology for articular cartilage damage is expected.
出版者
BioMed Central Ltd
収録物名
Inflammation and Regeneration
巻(号)
43(1)
ページ
56
刊行年月
2023-11-14
言語
英語
ハンドルURL
https://hdl.handle.net/11094/93294
eISSN
18808190
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1186/s41232-023-00307-0
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article