Autonomic function measurements for evaluating fatigue and quality of life in patients with breast cancer undergoing radiation therapy: a prospective longitudinal study

Aoki, Miwa; Kuratsune, Hirohiko; Yamamoto, Sena; Hirano, Toshiko; Hanaeda, Kumiko; Nishi, Yasuka; Okada, Tamami; Nadamura, Maki; Kobayashi, Chiho; Sumita, Emiko; Gotou, Junko; Koizumi, Masahiko; Arao, Harue

doi:https://doi.org/10.1186/S13014-023-02362-W

Autonomic function measurements for evaluating fatigue and quality of life in patients with breast cancer undergoing radiation therapy: a prospective longitudinal study

Aoki, Miwa; Kuratsune, Hirohiko; Yamamoto, Sena et al.

Radiation Oncology, 2023, 18, 171

アクセス数:1,130件（2025-12-04 12:53 集計）

固定URL: https://hdl.handle.net/11094/93316

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タイトル	Autonomic function measurements for evaluating fatigue and quality of life in patients with breast cancer undergoing radiation therapy: a prospective longitudinal study
著者	著者名 Aoki, Miwa
	NRID 1000050195533 1000050195533 著者名 Kuratsune, Hirohiko
	NRID 1000060796522 1000060796522 researchmap permalink 60796522 60796522 Scopus Author ID 57188590410 57188590410 著者名 Yamamoto, Sena
	著者名 Hirano, Toshiko
	著者名 Hanaeda, Kumiko
	著者名 Nishi, Yasuka
	著者名 Okada, Tamami
	著者名 Nadamura, Maki
	著者名 Kobayashi, Chiho
	著者名 Sumita, Emiko
	著者名 Gotou, Junko
	NRID 1000090186594 1000090186594 ORCID 0000-0003-3438-9811 0000-0003-3438-9811 researchmap permalink read0006874 read0006874 Scopus Author ID 7201931513 7201931513 著者名 Koizumi, Masahiko
	NRID 1000050326302 1000050326302 researchmap permalink read0201 read0201 Scopus Author ID 16311856300 16311856300 著者名 Arao, Harue
キーワード等	Autonomic nerve function
	Breast cancer
	Fatigue
	Radiation therapy
内容	Aoki M., Kuratsune H., Yamamoto S., et al. Autonomic function measurements for evaluating fatigue and quality of life in patients with breast cancer undergoing radiation therapy: a prospective longitudinal study. Radiation Oncology 18, 171 (2023); https://doi.org/10.1186/S13014-023-02362-W.
抄録	Background: Fatigue during radiation therapy in women with breast cancer can decrease quality of life (QOL), yet it is often underestimated and needs to be evaluated objectively. This longitudinal study aimed to evaluate fatigue and QOL of women with breast cancer undergoing radiotherapy with a simple autonomic function measurement. Methods: Women with breast cancer who underwent postoperative radiotherapy in eight cancer care hospitals in Chubu and Kinki regions in Japan were recruited between October 2021 and June 2022. The women underwent a self-administered questionnaire that included the Cancer Fatigue Scale (CFS) and the Short Form-8 Health Survey (SF-8) and an autonomic nervous function measurement using a simple, non-invasive device before (T0, baseline), mid (T1), and at the end (T2) of treatment. Results: The 57 women showed similar trends, with CFS scores and log LF/HF ratio being the highest at T0 and significantly decreasing at T1 (both p < 0.05). The log LF/HF trends differed between those with high and low baseline log LF/HF values. Women with mental component summary (MCS) score improvement (T0 to T2) had the highest log LF/HF ratio at T0 and had significantly lower log LF/HF values at T1 and T2 than at T0 (p < 0.01 and p < 0.05, respectively). The change of (⊿) MCS from T0 to T1 was negatively correlated with ⊿log LF/HF from T0 to T1 (r = − 0.36, p < 0.01). Conclusions: Measurement of autonomic nerve function with a simple device is useful for objective fatigue assessment during radiotherapy. Psychological support is important as improvement in mental health helps improve autonomic nerve function and, in turn, fatigue.
出版者	BioMed Central Ltd
収録物名	Radiation Oncology
巻(号)	18
ページ	171
刊行年月	2023-10-19
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93316
eISSN	1748717X
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1186/S13014-023-02362-W
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Radiation Oncology. 2023, 18, p. 171
DC.title	Autonomic function measurements for evaluating fatigue and quality of life in patients with breast cancer undergoing radiation therapy: a prospective longitudinal study
DC.creator	Aoki, Miwa
	Kuratsune, Hirohiko
	Yamamoto, Sena
	Hirano, Toshiko
	Hanaeda, Kumiko
	Nishi, Yasuka
	Okada, Tamami
	Nadamura, Maki
	Kobayashi, Chiho
	Sumita, Emiko
	Gotou, Junko
	Koizumi, Masahiko
	Arao, Harue
DC.publisher	BioMed Central Ltd
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-10-19
DC.identifier	https://doi.org/10.1186/S13014-023-02362-W
DC.subject	Autonomic nerve function
	Breast cancer
	Fatigue
	Radiation therapy
DC.description	Aoki M., Kuratsune H., Yamamoto S., et al. Autonomic function measurements for evaluating fatigue and quality of life in patients with breast cancer undergoing radiation therapy: a prospective longitudinal study. Radiation Oncology 18, 171 (2023); https://doi.org/10.1186/S13014-023-02362-W.
DCTERMS.abstract	Background: Fatigue during radiation therapy in women with breast cancer can decrease quality of life (QOL), yet it is often underestimated and needs to be evaluated objectively. This longitudinal study aimed to evaluate fatigue and QOL of women with breast cancer undergoing radiotherapy with a simple autonomic function measurement. Methods: Women with breast cancer who underwent postoperative radiotherapy in eight cancer care hospitals in Chubu and Kinki regions in Japan were recruited between October 2021 and June 2022. The women underwent a self-administered questionnaire that included the Cancer Fatigue Scale (CFS) and the Short Form-8 Health Survey (SF-8) and an autonomic nervous function measurement using a simple, non-invasive device before (T0, baseline), mid (T1), and at the end (T2) of treatment. Results: The 57 women showed similar trends, with CFS scores and log LF/HF ratio being the highest at T0 and significantly decreasing at T1 (both p < 0.05). The log LF/HF trends differed between those with high and low baseline log LF/HF values. Women with mental component summary (MCS) score improvement (T0 to T2) had the highest log LF/HF ratio at T0 and had significantly lower log LF/HF values at T1 and T2 than at T0 (p < 0.01 and p < 0.05, respectively). The change of (⊿) MCS from T0 to T1 was negatively correlated with ⊿log LF/HF from T0 to T1 (r = − 0.36, p < 0.01). Conclusions: Measurement of autonomic nerve function with a simple device is useful for objective fatigue assessment during radiotherapy. Psychological support is important as improvement in mental health helps improve autonomic nerve function and, in turn, fatigue.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93316
citation_title	Autonomic function measurements for evaluating fatigue and quality of life in patients with breast cancer undergoing radiation therapy: a prospective longitudinal study
citation_author	Aoki, Miwa
	Kuratsune, Hirohiko
	Yamamoto, Sena
	Hirano, Toshiko
	Hanaeda, Kumiko
	Nishi, Yasuka
	Okada, Tamami
	Nadamura, Maki
	Kobayashi, Chiho
	Sumita, Emiko
	Gotou, Junko
	Koizumi, Masahiko
	Arao, Harue
citation_publisher	BioMed Central Ltd
citation_language	英語
citation_date	2023-10-19
citation_journal_title	Radiation Oncology
citation_volume	18
citation_firstpage	171
citation_doi	https://doi.org/10.1186/S13014-023-02362-W
citation_public_url	https://hdl.handle.net/11094/93316

Autonomic function measurements for evaluating fatigue and quality of life in patients with breast cancer undergoing radiation therapy: a prospective longitudinal study

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