Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer

Hamada, Masakazu; Inaba, Hiroaki; Nishiyama, Kyoko; Yoshida, Sho; Yura, Yoshiaki; Matsumoto-Nakano, Michiyo; Uzawa, Narikazu

doi:https://doi.org/10.3390/ijms242015456

Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer

Hamada, Masakazu; Inaba, Hiroaki; Nishiyama, Kyoko et al.

International Journal of Molecular Sciences, 2023, 24(20), 15456

アクセス数:779件（2025-08-15 23:23 集計）

固定URL: https://hdl.handle.net/11094/93321

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タイトル	Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer
著者	NRID 1000080506361 1000080506361 researchmap permalink 6361 6361 Scopus Author ID 36616148000 36616148000 著者名 Hamada, Masakazu
	NRID 1000070359850 1000070359850 著者名 Inaba, Hiroaki
	NRID 1000070846542 1000070846542 researchmap permalink 02205 02205 著者名 Nishiyama, Kyoko
	NRID 1000040801048 1000040801048 著者名 Yoshida, Sho
	NRID 1000000136277 1000000136277 著者名 Yura, Yoshiaki
	NRID 1000030359848 1000030359848 著者名 Matsumoto-Nakano, Michiyo
	NRID 1000030345285 1000030345285 researchmap permalink read0212957 read0212957 Scopus Author ID 6603144046 6603144046 著者名 Uzawa, Narikazu
キーワード等	head and neck squamous cell carcinoma
	intratumor microbiome
	Leptotrichia
	oral bacteria
	RNA sequencing
	TCGA
	TCMA
内容	Hamada M., Inaba H., Nishiyama K., et al. Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer. International Journal of Molecular Sciences 24, 15456 (2023); https://doi.org/10.3390/ijms242015456.
抄録	The tumor microbiome, a relatively new research field, affects tumor progression through several mechanisms. The Cancer Microbiome Atlas (TCMA) database was recently published. In the present study, we used TCMA and The Cancer Genome Atlas and examined microbiome profiling in head and neck squamous cell carcinoma (HNSCC), the role of the intratumoral microbiota in the prognosis of HNSCC patients, and differentially expressed genes in tumor cells in relation to specific bacterial infections. We investigated 18 microbes at the genus level that differed between solid normal tissue (n = 22) and primary tumors (n = 154). The tissue microbiome profiles of Actinomyces, Fusobacterium, and Rothia at the genus level differed between the solid normal tissue and primary tumors of HNSCC patients. When the prognosis of groups with rates over and under the median for each microbe at the genus level was examined, rates for Leptotrichia which were over the median correlated with significantly higher overall survival rates. We then extracted 35 differentially expressed genes between the over- and under-the-median-for-Leptotrichia groups based on the criteria of >1.5 fold and p < 0.05 in the Mann–Whitney U-test. A pathway analysis showed that these Leptotrichia-related genes were associated with the pathways of Alzheimer disease, neurodegeneration-multiple diseases, prion disease, MAPK signaling, and PI3K-Akt signaling, while protein–protein interaction analysis revealed that these genes formed a dense network. In conclusion, probiotics and specific antimicrobial therapy targeting Leptotrichia may have an impact on the prognosis of HNSCC.
出版者	Multidisciplinary Digital Publishing Institute (MDPI)
収録物名	International Journal of Molecular Sciences
巻(号)	24(20)
ページ	15456
刊行年月	2023-10-22
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93321
PISSN	16616596
eISSN	14220067
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.3390/ijms242015456
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	International Journal of Molecular Sciences. 2023, 24(20), p. 15456
DC.title	Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer
DC.creator	Hamada, Masakazu
	Inaba, Hiroaki
	Nishiyama, Kyoko
	Yoshida, Sho
	Yura, Yoshiaki
	Matsumoto-Nakano, Michiyo
	Uzawa, Narikazu
DC.publisher	Multidisciplinary Digital Publishing Institute (MDPI)
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-10-22
DC.identifier	https://doi.org/10.3390/ijms242015456
DC.subject	head and neck squamous cell carcinoma
	intratumor microbiome
	Leptotrichia
	oral bacteria
	RNA sequencing
	TCGA
	TCMA
DC.description	Hamada M., Inaba H., Nishiyama K., et al. Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer. International Journal of Molecular Sciences 24, 15456 (2023); https://doi.org/10.3390/ijms242015456.
DCTERMS.abstract	The tumor microbiome, a relatively new research field, affects tumor progression through several mechanisms. The Cancer Microbiome Atlas (TCMA) database was recently published. In the present study, we used TCMA and The Cancer Genome Atlas and examined microbiome profiling in head and neck squamous cell carcinoma (HNSCC), the role of the intratumoral microbiota in the prognosis of HNSCC patients, and differentially expressed genes in tumor cells in relation to specific bacterial infections. We investigated 18 microbes at the genus level that differed between solid normal tissue (n = 22) and primary tumors (n = 154). The tissue microbiome profiles of Actinomyces, Fusobacterium, and Rothia at the genus level differed between the solid normal tissue and primary tumors of HNSCC patients. When the prognosis of groups with rates over and under the median for each microbe at the genus level was examined, rates for Leptotrichia which were over the median correlated with significantly higher overall survival rates. We then extracted 35 differentially expressed genes between the over- and under-the-median-for-Leptotrichia groups based on the criteria of >1.5 fold and p < 0.05 in the Mann–Whitney U-test. A pathway analysis showed that these Leptotrichia-related genes were associated with the pathways of Alzheimer disease, neurodegeneration-multiple diseases, prion disease, MAPK signaling, and PI3K-Akt signaling, while protein–protein interaction analysis revealed that these genes formed a dense network. In conclusion, probiotics and specific antimicrobial therapy targeting Leptotrichia may have an impact on the prognosis of HNSCC.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93321
citation_title	Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer
citation_author	Hamada, Masakazu
	Inaba, Hiroaki
	Nishiyama, Kyoko
	Yoshida, Sho
	Yura, Yoshiaki
	Matsumoto-Nakano, Michiyo
	Uzawa, Narikazu
citation_publisher	Multidisciplinary Digital Publishing Institute (MDPI)
citation_language	英語
citation_date	2023-10-22
citation_journal_title	International Journal of Molecular Sciences
citation_volume	24
citation_issue	20
citation_firstpage	15456
citation_doi	https://doi.org/10.3390/ijms242015456
citation_public_url	https://hdl.handle.net/11094/93321

Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer

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