Host bone microstructure for enhanced resistance to bacterial infections

Watanabe, Ryota; Matsugaki, Aira; Gokcekaya, Ozkan; Ozasa, Ryosuke; Matsumoto, Takuya; Takahashi, Hiroyuki; Yasui, Hidekazu; Nakano, Takayoshi

doi:https://doi.org/10.1016/j.bioadv.2023.213633

Host bone microstructure for enhanced resistance to bacterial infections

Watanabe, Ryota; Matsugaki, Aira; Gokcekaya, Ozkan et al.

Biomaterials Advances, 2023, 154, 213633

アクセス数:58件（2025-04-03 21:45 集計）

固定URL: https://hdl.handle.net/11094/93322

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タイトル	Host bone microstructure for enhanced resistance to bacterial infections
著者	著者名 Watanabe, Ryota
	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 著者名 Matsugaki, Aira
	ORCID 0000-0002-9258-858X 0000-0002-9258-858X Scopus Author ID 37051975500 37051975500 NRID 1000050988160 1000050988160 著者名 Gokcekaya, Ozkan
	NRID 1000080845347 1000080845347 ORCID 0000-0002-2773-072X 0000-0002-2773-072X researchmap permalink ozasa_r ozasa_r Scopus Author ID 56202812400 56202812400 著者名 Ozasa, Ryosuke
	NRID 1000040324793 1000040324793 著者名 Matsumoto, Takuya
	著者名 Takahashi, Hiroyuki
	著者名 Yasui, Hidekazu
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
キーワード等	Antimicrobial activity
	Bone matrix anisotropy
	Laser powder bed fusion
	Postoperative infection
	Surface topography
	Titanium alloy
内容	Watanabe R., Matsugaki A., Gokcekaya O., et al. Host bone microstructure for enhanced resistance to bacterial infections. Biomaterials Advances 154, 213633 (2023); https://doi.org/10.1016/j.bioadv.2023.213633.
抄録	Postoperative bacterial infection is a serious complication of orthopedic surgery. Not only infections that develop in the first few weeks after surgery but also late infections that develop years after surgery are serious problems. However, the relationship between host bone and infection activation has not yet been explored. Here, we report a novel association between host bone collagen/apatite microstructure and bacterial infection. The bone-mimetic-oriented micro-organized matrix structure was obtained by prolonged controlled cell alignment using a grooved-structured biomedical titanium alloy. Surprisingly, we have discovered that highly aligned osteoblasts have a potent inhibitory effect on Escherichia coli adhesion. Additionally, the oriented collagen/apatite micro-organization of the bone matrix showed excellent antibacterial resistance against Escherichia coli. The proposed mechanism for realizing the antimicrobial activity of the micro-organized bone matrix is by the controlled secretion of the antimicrobial peptides, including β-defensin 2 and β-defensin 3, from the highly aligned osteoblasts. Our findings contribute to the development of anti-infective strategies for orthopedic surgeries. The recovery of the intrinsically ordered bone matrix organization provides superior antibacterial resistance after surgery.
出版者	Elsevier Ltd
収録物名	Biomaterials Advances
巻(号)	154
ページ	213633
刊行年月	2023-11-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93322
eISSN	27729508
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.bioadv.2023.213633
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Biomaterials Advances. 2023, 154, p. 213633
DC.title	Host bone microstructure for enhanced resistance to bacterial infections
DC.creator	Watanabe, Ryota
	Matsugaki, Aira
	Gokcekaya, Ozkan
	Ozasa, Ryosuke
	Matsumoto, Takuya
	Takahashi, Hiroyuki
	Yasui, Hidekazu
	Nakano, Takayoshi
DC.publisher	Elsevier Ltd
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-11-01
DC.identifier	https://doi.org/10.1016/j.bioadv.2023.213633
DC.subject	Antimicrobial activity
	Bone matrix anisotropy
	Laser powder bed fusion
	Postoperative infection
	Surface topography
	Titanium alloy
DC.description	Watanabe R., Matsugaki A., Gokcekaya O., et al. Host bone microstructure for enhanced resistance to bacterial infections. Biomaterials Advances 154, 213633 (2023); https://doi.org/10.1016/j.bioadv.2023.213633.
DCTERMS.abstract	Postoperative bacterial infection is a serious complication of orthopedic surgery. Not only infections that develop in the first few weeks after surgery but also late infections that develop years after surgery are serious problems. However, the relationship between host bone and infection activation has not yet been explored. Here, we report a novel association between host bone collagen/apatite microstructure and bacterial infection. The bone-mimetic-oriented micro-organized matrix structure was obtained by prolonged controlled cell alignment using a grooved-structured biomedical titanium alloy. Surprisingly, we have discovered that highly aligned osteoblasts have a potent inhibitory effect on Escherichia coli adhesion. Additionally, the oriented collagen/apatite micro-organization of the bone matrix showed excellent antibacterial resistance against Escherichia coli. The proposed mechanism for realizing the antimicrobial activity of the micro-organized bone matrix is by the controlled secretion of the antimicrobial peptides, including β-defensin 2 and β-defensin 3, from the highly aligned osteoblasts. Our findings contribute to the development of anti-infective strategies for orthopedic surgeries. The recovery of the intrinsically ordered bone matrix organization provides superior antibacterial resistance after surgery.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93322
citation_title	Host bone microstructure for enhanced resistance to bacterial infections
citation_author	Watanabe, Ryota
	Matsugaki, Aira
	Gokcekaya, Ozkan
	Ozasa, Ryosuke
	Matsumoto, Takuya
	Takahashi, Hiroyuki
	Yasui, Hidekazu
	Nakano, Takayoshi
citation_publisher	Elsevier Ltd
citation_language	英語
citation_date	2023-11-01
citation_journal_title	Biomaterials Advances
citation_volume	154
citation_firstpage	213633
citation_doi	https://doi.org/10.1016/j.bioadv.2023.213633
citation_public_url	https://hdl.handle.net/11094/93322

Host bone microstructure for enhanced resistance to bacterial infections

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