Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality

Usui, Noriyoshi

doi:https://doi.org/10.1007/s12565-023-00747-1

Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality

Usui, Noriyoshi

Anatomical Science International, 2023, 99, 34-47

アクセス数:26件（2025-04-22 07:20 集計）

固定URL: https://hdl.handle.net/11094/93369

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タイトル	Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality
著者	NRID 1000000784076 1000000784076 ORCID 0000-0001-8079-8013 0000-0001-8079-8013 researchmap permalink noriyoshiusui noriyoshiusui Scopus Author ID 56404181300 56404181300 著者名 Usui, Noriyoshi
キーワード等	Autism spectrum disorder
	Brain evolution
	Deep layer
	Oligodendrocyte
	Sociality
内容	The version of record of this article, first published in Anatomical Science International, is available online at Publisher’s website: https://doi.org/10.1007/s12565-023-00747-1
抄録	Sociality is an instinctive property of organisms that live in relation to others and is a complex characteristic of higher order brain functions. However, the evolution of the human brain to acquire higher order brain functions, such as sociality, and the neural basis for executing these functions and their control mechanisms are largely unknown. Several studies have attempted to evaluate how human sociality was acquired during the course of evolution and the mechanisms controlling sociality from a neurodevelopment viewpoint. This review discusses these findings in the context of human brain evolution and the pathophysiology of autism spectrum disorder (ASD). Comparative genomic studies of postmortem primate brains have demonstrated human-specific regulatory mechanisms underlying higher order brain functions, providing evidence for the contribution of oligodendrocytes to human brain function. Functional analyses of the causative genes of ASD in animal models have demonstrated that the neural basis of social behavior is associated with layer 6 (L6) of the neocortex and oligodendrocytes. These findings demonstrate that both neurons and oligodendrocytes contribute to the neural basis and molecular mechanisms underlying human brain evolution and social functioning. This review provides novel insights into sociability and the corresponding neural bases of brain disorders and evolution.
出版者	Springer
収録物名	Anatomical Science International
巻(号)	99
ページ	34-47
刊行年月	2023-11-27
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93369
PISSN	14476959
eISSN	1447073X
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s12565-023-00747-1
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Anatomical Science International. 2023, 99, p. 34-47
DC.title	Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality
DC.creator	Usui, Noriyoshi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-11-27
DC.identifier	https://doi.org/10.1007/s12565-023-00747-1
DC.subject	Autism spectrum disorder
	Brain evolution
	Deep layer
	Oligodendrocyte
	Sociality
DC.description	The version of record of this article, first published in Anatomical Science International, is available online at Publisher’s website: https://doi.org/10.1007/s12565-023-00747-1
DCTERMS.abstract	Sociality is an instinctive property of organisms that live in relation to others and is a complex characteristic of higher order brain functions. However, the evolution of the human brain to acquire higher order brain functions, such as sociality, and the neural basis for executing these functions and their control mechanisms are largely unknown. Several studies have attempted to evaluate how human sociality was acquired during the course of evolution and the mechanisms controlling sociality from a neurodevelopment viewpoint. This review discusses these findings in the context of human brain evolution and the pathophysiology of autism spectrum disorder (ASD). Comparative genomic studies of postmortem primate brains have demonstrated human-specific regulatory mechanisms underlying higher order brain functions, providing evidence for the contribution of oligodendrocytes to human brain function. Functional analyses of the causative genes of ASD in animal models have demonstrated that the neural basis of social behavior is associated with layer 6 (L6) of the neocortex and oligodendrocytes. These findings demonstrate that both neurons and oligodendrocytes contribute to the neural basis and molecular mechanisms underlying human brain evolution and social functioning. This review provides novel insights into sociability and the corresponding neural bases of brain disorders and evolution.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93369
citation_title	Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality
citation_author	Usui, Noriyoshi
citation_publisher	Springer
citation_language	英語
citation_date	2023-11-27
citation_journal_title	Anatomical Science International
citation_volume	99
citation_firstpage	34
citation_lastpage	47
citation_doi	https://doi.org/10.1007/s12565-023-00747-1
citation_public_url	https://hdl.handle.net/11094/93369

Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality

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