Heart Disease Mortality in Cancer Survivors: A Population-Based Study in Japan

Gon, Yasufumi; Zha, Ling; Sasaki, Tsutomu et al.

Journal of the American Heart Association, 2023, 12(23), e029967

アクセス数:1,272件（2025-09-01 16:42 集計）

固定URL: https://hdl.handle.net/11094/93373

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タイトル
Heart Disease Mortality in Cancer Survivors: A Population-Based Study in Japan
著者
NRID
1000070751311 1000070751311
researchmap permalink
y-gon y-gon
Scopus Author ID
56565092900 56565092900
著者名
Gon, Yasufumi
researchmap permalink
lingzha lingzha
Scopus Author ID
57193822882 57193822882
著者名
Zha, Ling
NRID
1000020534879 1000020534879
ORCID
0000-0001-8726-978X 0000-0001-8726-978X
researchmap permalink
tsutomusasaki1111 tsutomusasaki1111
Scopus Author ID
7407394272 7407394272
著者名
Sasaki, Tsutomu
NRID
1000010728893 1000010728893
著者名
Morishima, Toshitaka
NRID
1000060183026 1000060183026
researchmap permalink
read0185105 read0185105
著者名
Ohno, Yuko
NRID
1000090230044 1000090230044
ORCID
0000-0002-0874-7542 0000-0002-0874-7542
researchmap permalink
read0207787 read0207787
Scopus Author ID
7202006099 7202006099
著者名
Mochizuki, Hideki
NRID
1000050270674 1000050270674
researchmap permalink
read_0159567 read_0159567
Scopus Author ID
7005649935 7005649935
著者名
Sobue, Tomotaka
NRID
1000080501824 1000080501824
著者名
Miyashiro, Isao
キーワード等
cancer
cancer survivors
cohort study
heart disease
mortality
内容
Gon Y., Zha L., Sasaki T., et al. Heart Disease Mortality in Cancer Survivors: A Population-Based Study in Japan. Journal of the American Heart Association 12, e029967 (2023); https://doi.org/10.1161/JAHA.123.029967.
抄録
BACKGROUND: Data on the risk of cardiovascular-related mortality in patients with cancer are limited. METHODS AND RESULTS: This retrospective cohort study used data from the Osaka Cancer Registry and vital statistics in Japan between 1985 and 2013. The causes of death were investigated, and the risk of fatal heart disease was analyzed. Standardized mortality ratios were calculated to compare the risk of fatal heart disease between patients with cancer and the general population. Fine and Gray competing risk regression models were used to assess the risk of fatal heart disease among patients with cancer. In total, 682 886 patients with cancer were included in the analysis, and 335 635 patients died during the study period. Heart disease was the leading cause of noncancer deaths, with 10 686 deaths. Among the patients who died of heart disease, 5017 had ischemic heart disease, 3598 had heart failure, 356 had hypertensive disease, and 1715 had other heart diseases. The standardized mortality ratio for heart disease was 2.80 (95% CI, 2.74-2.85). The standardized mortality ratio for ischemic heart disease, heart failure, and hypertensive disease were 3.26 (95% CI, 3.17-3.35), 2.69 (95% CI, 2.60-2.78), and 5.97 (95% CI, 5.38-6.63), respectively. The risk of fatal heart disease increased over time after cancer diagnosis. Men were more likely to die of heart disease than women (subdistribution hazard ratio, 1.08 [95% CI, 1.02-1.16]). The risk of fatal heart disease among cancer survivors has decreased in recent years. CONCLUSIONS: Cancer survivors have a higher risk of fatal heart disease than the general population.
出版者
AHA (American Heart Association) (出版社Wolters Kluwer / LWW, Lippincott Williams & Wilkins）
収録物名
Journal of the American Heart Association
巻(号)
12(23)
ページ
e029967
刊行年月
2023-12-05
言語
英語
ハンドルURL
https://hdl.handle.net/11094/93373
eISSN
20479980
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1161/JAHA.123.029967
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article