Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice

Yasuda, Shumpei P.; Miyasaka, Yuki; Hou, Xuehan; Obara, Yo; Shitara, Hiroshi; Seki, Yuta; Matsuoka, Kunie; Takahashi, Ai; Wakai, Eri; Hibino, Hiroshi; Takada, Toyoyuki; Shiroishi, Toshihiko; Kominami, Ryo; Kikkawa, Yoshiaki

doi:https://doi.org/10.3390/biomedicines10092221

Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice

Yasuda, Shumpei P.; Miyasaka, Yuki; Hou, Xuehan et al.

Biomedicines, 2022, 10(9), 2221

アクセス数:1,315件（2025-08-14 12:54 集計）

固定URL: https://hdl.handle.net/11094/93410

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
Biomedicines_10_9_2221	pdf	なし	5.50 MB	99	2024.01.15

Creative Commons : 表示

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice
著者	NRID 1000050534012 1000050534012 著者名 Yasuda, Shumpei P.
	著者名 Miyasaka, Yuki
	著者名 Hou, Xuehan
	著者名 Obara, Yo
	著者名 Shitara, Hiroshi
	NRID 1000010615636 1000010615636 著者名 Seki, Yuta
	NRID 1000040291158 1000040291158 著者名 Matsuoka, Kunie
	著者名 Takahashi, Ai
	NRID 1000040964896 1000040964896 researchmap permalink eri_wakai eri_wakai 著者名 Wakai, Eri
	NRID 1000070314317 1000070314317 researchmap permalink hiroshi_hibino hiroshi_hibino Scopus Author ID 7007020846 7007020846 著者名 Hibino, Hiroshi
	NRID 1000020356257 1000020356257 著者名 Takada, Toyoyuki
	NRID 1000090171058 1000090171058 著者名 Shiroishi, Toshihiko
	NRID 1000040133615 1000040133615 著者名 Kominami, Ryo
	NRID 1000020280787 1000020280787 著者名 Kikkawa, Yoshiaki
キーワード等	age-related hearing loss
	ahl loci
	C57BL/6J strain
	congenic strain
	consomic strain
	MSM/Ms strain
内容	Yasuda S.P., Miyasaka Y., Hou X., et al. Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice. Biomedicines 10, 2221 (2022); https://doi.org/10.3390/biomedicines10092221.
抄録	An MSM/Ms strain was established using Japanese wild mice, which exhibit resistance to several phenotypes associated with aging, such as obesity, inflammation, and tumorigenesis, compared to common inbred mouse strains. MSM/Ms strain is resistant to age-related hearing loss, and their auditory abilities are sustained for long durations. The age-related hearing loss 3 (ahl3) locus contributes to age-related hearing in MSM/Ms strain. We generated ahl3 congenic strains by transferring a genomic region on chromosome 17 from MSM/Ms mice into C57BL/6J mice. Although C57BL/6J mice develop age-related hearing loss because of the ahl allele of the cadherin 23 gene, the development of middle- to high-frequency hearing loss was significantly delayed in an ahl3 congenic strain. Moreover, the novel age-related hearing loss 10 (ahl10) locus associated with age-related hearing resistance in MSM/Ms strain was mapped to chromosome 12. Although the resistance effects in ahl10 congenic strain were slightly weaker than those in ahl3 congenic strain, slow progression of age-related hearing loss was confirmed in ahl10 congenic strain despite harboring the ahl allele of cadherin 23. These results suggest that causative genes and polymorphisms of the ahl3 and ahl10 loci are important targets for the prevention and treatment of age-related hearing loss.
出版者	MDPI
収録物名	Biomedicines
巻(号)	10(9)
ページ	2221
刊行年月	2022-09-07
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93410
eISSN	22279059
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.3390/biomedicines10092221
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Biomedicines. 2022, 10(9), p. 2221
DC.title	Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice
DC.creator	Yasuda, Shumpei P.
	Miyasaka, Yuki
	Hou, Xuehan
	Obara, Yo
	Shitara, Hiroshi
	Seki, Yuta
	Matsuoka, Kunie
	Takahashi, Ai
	Wakai, Eri
	Hibino, Hiroshi
	Takada, Toyoyuki
	Shiroishi, Toshihiko
	Kominami, Ryo
	Kikkawa, Yoshiaki
DC.publisher	MDPI
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-09-07
DC.identifier	https://doi.org/10.3390/biomedicines10092221
DC.subject	age-related hearing loss
	ahl loci
	C57BL/6J strain
	congenic strain
	consomic strain
	MSM/Ms strain
DC.description	Yasuda S.P., Miyasaka Y., Hou X., et al. Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice. Biomedicines 10, 2221 (2022); https://doi.org/10.3390/biomedicines10092221.
DCTERMS.abstract	An MSM/Ms strain was established using Japanese wild mice, which exhibit resistance to several phenotypes associated with aging, such as obesity, inflammation, and tumorigenesis, compared to common inbred mouse strains. MSM/Ms strain is resistant to age-related hearing loss, and their auditory abilities are sustained for long durations. The age-related hearing loss 3 (ahl3) locus contributes to age-related hearing in MSM/Ms strain. We generated ahl3 congenic strains by transferring a genomic region on chromosome 17 from MSM/Ms mice into C57BL/6J mice. Although C57BL/6J mice develop age-related hearing loss because of the ahl allele of the cadherin 23 gene, the development of middle- to high-frequency hearing loss was significantly delayed in an ahl3 congenic strain. Moreover, the novel age-related hearing loss 10 (ahl10) locus associated with age-related hearing resistance in MSM/Ms strain was mapped to chromosome 12. Although the resistance effects in ahl10 congenic strain were slightly weaker than those in ahl3 congenic strain, slow progression of age-related hearing loss was confirmed in ahl10 congenic strain despite harboring the ahl allele of cadherin 23. These results suggest that causative genes and polymorphisms of the ahl3 and ahl10 loci are important targets for the prevention and treatment of age-related hearing loss.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93410
citation_title	Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice
citation_author	Yasuda, Shumpei P.
	Miyasaka, Yuki
	Hou, Xuehan
	Obara, Yo
	Shitara, Hiroshi
	Seki, Yuta
	Matsuoka, Kunie
	Takahashi, Ai
	Wakai, Eri
	Hibino, Hiroshi
	Takada, Toyoyuki
	Shiroishi, Toshihiko
	Kominami, Ryo
	Kikkawa, Yoshiaki
citation_publisher	MDPI
citation_language	英語
citation_date	2022-09-07
citation_journal_title	Biomedicines
citation_volume	10
citation_issue	9
citation_firstpage	2221
citation_doi	https://doi.org/10.3390/biomedicines10092221
citation_public_url	https://hdl.handle.net/11094/93410

Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice

閲覧可能ファイル

論文情報

論文詳細を表示