Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia

Inaba, Hiroyoshi; Kai, Ryota; Namba, Hisaaki; Sotoyama, Hidekazu; Jodo, Eiichi; Nin, Fumiaki; Hibino, Hiroshi; Yabe, Hirooki; Eifuku, Satoshi; Horii, Arata; Nawa, Hiroyuki

doi:https://doi.org/10.1093/schizbullopen/sgaa070

Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia

Inaba, Hiroyoshi; Kai, Ryota; Namba, Hisaaki et al.

Schizophrenia Bulletin Open, 2021, 2(1), sgaa070

アクセス数:892件（2025-08-14 16:35 集計）

固定URL: https://hdl.handle.net/11094/93414

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タイトル	Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia
著者	著者名 Inaba, Hiroyoshi
	NRID 1000050870367 1000050870367 著者名 Kai, Ryota
	NRID 1000090332650 1000090332650 著者名 Namba, Hisaaki
	NRID 1000040377198 1000040377198 著者名 Sotoyama, Hidekazu
	NRID 1000050211975 1000050211975 著者名 Jodo, Eiichi
	NRID 1000080644905 1000080644905 著者名 Nin, Fumiaki
	NRID 1000070314317 1000070314317 researchmap permalink hiroshi_hibino hiroshi_hibino Scopus Author ID 7007020846 7007020846 著者名 Hibino, Hiroshi
	NRID 1000060210316 1000060210316 著者名 Yabe, Hirooki
	NRID 1000070262508 1000070262508 著者名 Eifuku, Satoshi
	NRID 1000030294060 1000030294060 著者名 Horii, Arata
	NRID 1000050183083 1000050183083 著者名 Nawa, Hiroyuki
キーワード等	ABR
	ASSR
	EGFR
	MMN
	PAC
内容	Kai R., Namba H., Sotoyama H., et al. Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia. Schizophrenia Bulletin Open 2, sgaa070 (2021); https://doi.org/10.1093/schizbullopen/sgaa070.
抄録	Auditory neurophysiological responses, such as steady-state responses, event-related potential P300/P3, and phase-Amplitude coupling, are promising translational biomarkers for schizophrenia, but their molecular underpinning is poorly understood. Focusing on ErbB receptor signals that are implicated in both schizophrenia and auditory processing/cognition, we explored the causal biological links between ErbB signals and these auditory traits with an experimental intervention into rats. We peripherally challenged rat pups with one of the amniotic ErbB ligands, epidermal growth factor (EGF), and characterized its consequence on the series of these auditory electrocorticographic measures. Auditory brainstem responses (ABRs) and cortical ON responses were also assessed under anesthesia to estimate the influence of higher brain regions. An auditory steady-state paradigm revealed attenuation of spectral power and phase synchrony to 40-Hz stimuli in EGF-challenged rats. We observed a reduction in duration mismatch negativity-like potentials and a delay of P3a responses, all of which are relevant to the reported auditory pathophysiological traits of patients with schizophrenia. Moreover, the perinatal EGF challenges resulted in enhanced theta-Alpha/beta and theta-gamma coupling within the auditory cortex and changes in ABRs. However, the EGF challenges retained the normal ranges of cortical ON responses, potentially ruling out their fundamental auditory deficits. Perinatal exposure of an ErbB ligand to rats strikingly reproduced the whole series of aberrant auditory responses and oscillations previously reported in patients with schizophrenia. Accordingly, these findings suggest that developmental deficits in ErbB/EGF signaling might be involved in the auditory pathophysiology associated with schizophrenia.
出版者	Oxford University Press
収録物名	Schizophrenia Bulletin Open
巻(号)	2(1)
ページ	sgaa070
刊行年月	2021-01-19
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93414
eISSN	26327899
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1093/schizbullopen/sgaa070
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Schizophrenia Bulletin Open. 2021, 2(1), p. sgaa070
DC.title	Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia
DC.creator	Inaba, Hiroyoshi
	Kai, Ryota
	Namba, Hisaaki
	Sotoyama, Hidekazu
	Jodo, Eiichi
	Nin, Fumiaki
	Hibino, Hiroshi
	Yabe, Hirooki
	Eifuku, Satoshi
	Horii, Arata
	Nawa, Hiroyuki
DC.publisher	Oxford University Press
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-01-19
DC.identifier	https://doi.org/10.1093/schizbullopen/sgaa070
DC.subject	ABR
	ASSR
	EGFR
	MMN
	PAC
DC.description	Kai R., Namba H., Sotoyama H., et al. Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia. Schizophrenia Bulletin Open 2, sgaa070 (2021); https://doi.org/10.1093/schizbullopen/sgaa070.
DCTERMS.abstract	Auditory neurophysiological responses, such as steady-state responses, event-related potential P300/P3, and phase-Amplitude coupling, are promising translational biomarkers for schizophrenia, but their molecular underpinning is poorly understood. Focusing on ErbB receptor signals that are implicated in both schizophrenia and auditory processing/cognition, we explored the causal biological links between ErbB signals and these auditory traits with an experimental intervention into rats. We peripherally challenged rat pups with one of the amniotic ErbB ligands, epidermal growth factor (EGF), and characterized its consequence on the series of these auditory electrocorticographic measures. Auditory brainstem responses (ABRs) and cortical ON responses were also assessed under anesthesia to estimate the influence of higher brain regions. An auditory steady-state paradigm revealed attenuation of spectral power and phase synchrony to 40-Hz stimuli in EGF-challenged rats. We observed a reduction in duration mismatch negativity-like potentials and a delay of P3a responses, all of which are relevant to the reported auditory pathophysiological traits of patients with schizophrenia. Moreover, the perinatal EGF challenges resulted in enhanced theta-Alpha/beta and theta-gamma coupling within the auditory cortex and changes in ABRs. However, the EGF challenges retained the normal ranges of cortical ON responses, potentially ruling out their fundamental auditory deficits. Perinatal exposure of an ErbB ligand to rats strikingly reproduced the whole series of aberrant auditory responses and oscillations previously reported in patients with schizophrenia. Accordingly, these findings suggest that developmental deficits in ErbB/EGF signaling might be involved in the auditory pathophysiology associated with schizophrenia.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International
DC.format	93414
citation_title	Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia
citation_author	Inaba, Hiroyoshi
	Kai, Ryota
	Namba, Hisaaki
	Sotoyama, Hidekazu
	Jodo, Eiichi
	Nin, Fumiaki
	Hibino, Hiroshi
	Yabe, Hirooki
	Eifuku, Satoshi
	Horii, Arata
	Nawa, Hiroyuki
citation_publisher	Oxford University Press
citation_language	英語
citation_date	2021-01-19
citation_journal_title	Schizophrenia Bulletin Open
citation_volume	2
citation_issue	1
citation_firstpage	sgaa070
citation_doi	https://doi.org/10.1093/schizbullopen/sgaa070
citation_public_url	https://hdl.handle.net/11094/93414

Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia

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