Integrative and theoretical research on the architecture of a biological system and its disorder

Uchida, Shinichi; Asai, Yoshiyuki; Kariya, Yoshiaki; Tsumoto, Kunichika; Hibino, Hiroshi; Honma, Masashi; Abe, Takeshi; Nin, Fumiaki; Kurata, Yasutaka; Furutani, Kazuharu; Suzuki, Hiroshi; Kitano, Hiroaki; Inoue, Ryuji; Kurachi, Yoshihisa

doi:https://doi.org/10.1007/s12576-019-00667-8

Integrative and theoretical research on the architecture of a biological system and its disorder

Uchida, Shinichi; Asai, Yoshiyuki; Kariya, Yoshiaki et al.

Journal of Physiological Sciences, 2019, 69, 433-451

アクセス数:1,482件（2025-08-14 17:09 集計）

固定URL: https://hdl.handle.net/11094/93418

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タイトル	Integrative and theoretical research on the architecture of a biological system and its disorder
著者	NRID 1000050262184 1000050262184 著者名 Uchida, Shinichi
	NRID 1000000415639 1000000415639 著者名 Asai, Yoshiyuki
	NRID 1000020633168 1000020633168 著者名 Kariya, Yoshiaki
	NRID 1000070353331 1000070353331 著者名 Tsumoto, Kunichika
	NRID 1000070314317 1000070314317 researchmap permalink hiroshi_hibino hiroshi_hibino Scopus Author ID 7007020846 7007020846 著者名 Hibino, Hiroshi
	NRID 1000060401072 1000060401072 著者名 Honma, Masashi
	NRID 1000010819402 1000010819402 著者名 Abe, Takeshi
	NRID 1000080644905 1000080644905 著者名 Nin, Fumiaki
	NRID 1000000267725 1000000267725 著者名 Kurata, Yasutaka
	NRID 1000040452437 1000040452437 著者名 Furutani, Kazuharu
	NRID 1000080206523 1000080206523 著者名 Suzuki, Hiroshi
	NRID 1000080500256 1000080500256 著者名 Kitano, Hiroaki
	NRID 1000030232573 1000030232573 著者名 Inoue, Ryuji
	NRID 1000030142011 1000030142011 researchmap permalink read0042758 read0042758 著者名 Kurachi, Yoshihisa
キーワード等	Computer simulation
	Omics study
	Physiological experiments
	Software platform
	Systems biology
内容	Uchida S., Asai Y., Kariya Y., et al. Integrative and theoretical research on the architecture of a biological system and its disorder. Journal of Physiological Sciences , (2019); https://doi.org/10.1007/s12576-019-00667-8.
抄録	An organism stems from assemblies of a variety of cells and proteins. This complex system serves as a unit, and it exhibits highly sophisticated functions in response to exogenous stimuli that change over time. The complete sequencing of the entire human genome has allowed researchers to address the enigmas of life and disease at the gene- or molecular-based level. The consequence of such studies is the rapid accumulation of a multitude of data at multiple levels, ranging from molecules to the whole body, that has necessitated the development of entirely new concepts, tools, and methodologies to analyze and integrate these data. This necessity has given birth to systems biology, an advanced theoretical and practical research framework that has totally changed the directions of not only basic life science but also medicine. During the symposium of the 95th Annual Meeting of The Physiological Society of Japan 2018, five researchers reported on their respective studies on systems biology. The topics included reactions of drugs, ion-transport architecture in an epithelial system, multi-omics in renal disease, cardiac electrophysiological systems, and a software platform for computer simulation. In this review article these authors have summarized recent achievements in the field and discuss next-generation studies on health and disease.
出版者	Springer
収録物名	Journal of Physiological Sciences
巻(号)	69
ページ	433-451
刊行年月	2019-05-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93418
PISSN	18806546
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s12576-019-00667-8
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Physiological Sciences. 2019, 69, p. 433-451
DC.title	Integrative and theoretical research on the architecture of a biological system and its disorder
DC.creator	Uchida, Shinichi
	Asai, Yoshiyuki
	Kariya, Yoshiaki
	Tsumoto, Kunichika
	Hibino, Hiroshi
	Honma, Masashi
	Abe, Takeshi
	Nin, Fumiaki
	Kurata, Yasutaka
	Furutani, Kazuharu
	Suzuki, Hiroshi
	Kitano, Hiroaki
	Inoue, Ryuji
	Kurachi, Yoshihisa
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2019-05-01
DC.identifier	https://doi.org/10.1007/s12576-019-00667-8
DC.subject	Computer simulation
	Omics study
	Physiological experiments
	Software platform
	Systems biology
DC.description	Uchida S., Asai Y., Kariya Y., et al. Integrative and theoretical research on the architecture of a biological system and its disorder. Journal of Physiological Sciences , (2019); https://doi.org/10.1007/s12576-019-00667-8.
DCTERMS.abstract	An organism stems from assemblies of a variety of cells and proteins. This complex system serves as a unit, and it exhibits highly sophisticated functions in response to exogenous stimuli that change over time. The complete sequencing of the entire human genome has allowed researchers to address the enigmas of life and disease at the gene- or molecular-based level. The consequence of such studies is the rapid accumulation of a multitude of data at multiple levels, ranging from molecules to the whole body, that has necessitated the development of entirely new concepts, tools, and methodologies to analyze and integrate these data. This necessity has given birth to systems biology, an advanced theoretical and practical research framework that has totally changed the directions of not only basic life science but also medicine. During the symposium of the 95th Annual Meeting of The Physiological Society of Japan 2018, five researchers reported on their respective studies on systems biology. The topics included reactions of drugs, ion-transport architecture in an epithelial system, multi-omics in renal disease, cardiac electrophysiological systems, and a software platform for computer simulation. In this review article these authors have summarized recent achievements in the field and discuss next-generation studies on health and disease.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93418
citation_title	Integrative and theoretical research on the architecture of a biological system and its disorder
citation_author	Uchida, Shinichi
	Asai, Yoshiyuki
	Kariya, Yoshiaki
	Tsumoto, Kunichika
	Hibino, Hiroshi
	Honma, Masashi
	Abe, Takeshi
	Nin, Fumiaki
	Kurata, Yasutaka
	Furutani, Kazuharu
	Suzuki, Hiroshi
	Kitano, Hiroaki
	Inoue, Ryuji
	Kurachi, Yoshihisa
citation_publisher	Springer
citation_language	英語
citation_date	2019-05-01
citation_journal_title	Journal of Physiological Sciences
citation_volume	69
citation_firstpage	433
citation_lastpage	451
citation_doi	https://doi.org/10.1007/s12576-019-00667-8
citation_public_url	https://hdl.handle.net/11094/93418

Integrative and theoretical research on the architecture of a biological system and its disorder

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