Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function

Abe, Gabriela L.; Sasaki, Jun-Ichi; Tsuboi, Ririko; Kohno, Tomoki; Kitagawa, Haruaki; Imazato, Satoshi

doi:https://doi.org/10.1002/jbm.b.35365

Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function

Abe, Gabriela L.; Sasaki, Jun-Ichi; Tsuboi, Ririko et al.

Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2024, 112(1), e35365

アクセス数:48件（2025-04-22 06:02 集計）

固定URL: https://hdl.handle.net/11094/93453

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タイトル	Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function
著者	NRID 1000030964952 1000030964952 ORCID 0000-0001-8843-1697 0000-0001-8843-1697 researchmap permalink gabriela_abe gabriela_abe 著者名 Abe, Gabriela L.
	NRID 1000050530490 1000050530490 researchmap permalink Sasaki_JI Sasaki_JI Scopus Author ID 36138008500 36138008500 著者名 Sasaki, Jun-Ichi
	NRID 1000020827430 1000020827430 researchmap permalink tsuboi_ririko tsuboi_ririko 著者名 Tsuboi, Ririko
	NRID 1000010839202 1000010839202 researchmap permalink tomoki-kohno tomoki-kohno 著者名 Kohno, Tomoki
	NRID 1000050736246 1000050736246 ORCID 0000-0002-5270-4865 0000-0002-5270-4865 researchmap permalink kitagawa_h kitagawa_h Scopus Author ID 55267186700 55267186700 著者名 Kitagawa, Haruaki
	NRID 1000080243244 1000080243244 ORCID 0000-0003-3655-4809 0000-0003-3655-4809 researchmap permalink read0014210 read0014210 Scopus Author ID 55994423600 55994423600 著者名 Imazato, Satoshi
キーワード等	barrier membrane
	bilayer membrane
	guided bone regeneration
	polycaprolactone
	polylactic acid
内容	This is the peer reviewed version of the following article: Abe G.L., Sasaki J.I., Tsuboi R., et al. Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function. Journal of Biomedical Materials Research - Part B Applied Biomaterials 112, e35365 (2024), which has been published in final form at https://doi.org/10.1002/jbm.b.35365. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
抄録	Guided bone regeneration (GBR) is a treatment strategy used to recover bone volume. Barrier membranes are a key component of GBR protocols, and their properties can impact treatment outcomes. This study investigated the efficacy of an experimental, slow-degrading, bilayer barrier membrane for application in GBR using in vivo animal models. A synthetic copolymer of poly(lactic acid/caprolactone) (PLCL) was used to prepare a slow-degrading bilayer membrane. The biodegradability of PLCL was evaluated by subcutaneous implantation in a rat model. The barrier function of the PLCL membrane was investigated in a rat calvaria defect model and compared with commercially available membranes composed of type I collagen (Col) and poly(lactic-co-glycolic acid) (PLGA). An alveolar bone defect model in beagle dogs was used to simulate GBR protocols to evaluate the bone regeneration ability of the experimental PLCL membrane. The PLCL membrane showed slow biodegradation, resulting in an efficient and prolonged barrier function compared with commercial materials. In turn, this barrier function enabled the space-making ability of PLCL membrane and facilitated bone regeneration. In the alveolar bone defect model, significantly greater regeneration was achieved by treatment with PLCL membrane compared with Col and PLGA membranes. Additionally, a continuous alveolar ridge contour was observed in PLCL-treated bone defects. In conclusion, the PLCL bilayer membrane is a promising biomaterial for use in GBR given its slow degradation and prolonged barrier function.
出版者	John Wiley and Sons Inc
収録物名	Journal of Biomedical Materials Research - Part B Applied Biomaterials
巻(号)	112(1)
ページ	e35365
刊行年月	2024-01-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93453
PISSN	15524973
eISSN	15524981
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1002/jbm.b.35365
アクセス権	open access
権利情報	© 2023 Wiley Periodicals LLC.
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2024, 112(1), p. e35365
DC.title	Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function
DC.creator	Abe, Gabriela L.
	Sasaki, Jun-Ichi
	Tsuboi, Ririko
	Kohno, Tomoki
	Kitagawa, Haruaki
	Imazato, Satoshi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-01-01
DC.identifier	https://doi.org/10.1002/jbm.b.35365
DC.subject	barrier membrane
	bilayer membrane
	guided bone regeneration
	polycaprolactone
	polylactic acid
DC.description	This is the peer reviewed version of the following article: Abe G.L., Sasaki J.I., Tsuboi R., et al. Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function. Journal of Biomedical Materials Research - Part B Applied Biomaterials 112, e35365 (2024), which has been published in final form at https://doi.org/10.1002/jbm.b.35365. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
DCTERMS.abstract	Guided bone regeneration (GBR) is a treatment strategy used to recover bone volume. Barrier membranes are a key component of GBR protocols, and their properties can impact treatment outcomes. This study investigated the efficacy of an experimental, slow-degrading, bilayer barrier membrane for application in GBR using in vivo animal models. A synthetic copolymer of poly(lactic acid/caprolactone) (PLCL) was used to prepare a slow-degrading bilayer membrane. The biodegradability of PLCL was evaluated by subcutaneous implantation in a rat model. The barrier function of the PLCL membrane was investigated in a rat calvaria defect model and compared with commercially available membranes composed of type I collagen (Col) and poly(lactic-co-glycolic acid) (PLGA). An alveolar bone defect model in beagle dogs was used to simulate GBR protocols to evaluate the bone regeneration ability of the experimental PLCL membrane. The PLCL membrane showed slow biodegradation, resulting in an efficient and prolonged barrier function compared with commercial materials. In turn, this barrier function enabled the space-making ability of PLCL membrane and facilitated bone regeneration. In the alveolar bone defect model, significantly greater regeneration was achieved by treatment with PLCL membrane compared with Col and PLGA membranes. Additionally, a continuous alveolar ridge contour was observed in PLCL-treated bone defects. In conclusion, the PLCL bilayer membrane is a promising biomaterial for use in GBR given its slow degradation and prolonged barrier function.
DC.rights	© 2023 Wiley Periodicals LLC.
DC.format	93453
citation_title	Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function
citation_author	Abe, Gabriela L.
	Sasaki, Jun-Ichi
	Tsuboi, Ririko
	Kohno, Tomoki
	Kitagawa, Haruaki
	Imazato, Satoshi
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2024-01-01
citation_journal_title	Journal of Biomedical Materials Research - Part B Applied Biomaterials
citation_volume	112
citation_issue	1
citation_firstpage	e35365
citation_doi	https://doi.org/10.1002/jbm.b.35365
citation_public_url	https://hdl.handle.net/11094/93453

Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function

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