Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics

Otani, Tomohiro; Miyata, Kota; Miki, Atsuya; Wada, Shigeo

doi:https://doi.org/10.1016/j.medengphy.2023.104086

Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics

Otani, Tomohiro; Miyata, Kota; Miki, Atsuya et al.

Medical Engineering and Physics, 2024, 123, 104086

アクセス数:439件（2025-08-28 10:55 集計）

固定URL: https://hdl.handle.net/11094/93456

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
MedEngPhys_123_104086	pdf	なし	2.00 MB	21	2025.01.01

Creative Commons : 表示 - 非営利 - 改変禁止

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics
著者	NRID 1000040778990 1000040778990 ORCID 0000-0002-6431-2703 0000-0002-6431-2703 researchmap permalink bigvalley bigvalley Scopus Author ID 55625962900 55625962900 著者名 Otani, Tomohiro
	著者名 Miyata, Kota
	NRID 1000030437404 1000030437404 著者名 Miki, Atsuya
	NRID 1000070240546 1000070240546 researchmap permalink shigeo41010 shigeo41010 Scopus Author ID 7401983636 7401983636 著者名 Wada, Shigeo
キーワード等	Central retinal vessel
	Glaucoma
	Optic nerves head
	Optical coherence tomography
	Smoothed finite element method
内容	Otani T., Miyata K., Miki A., et al. Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics. Medical Engineering and Physics 123, 104086 (2024); https://doi.org/10.1016/j.medengphy.2023.104086.
抄録	Optic nerve head (ONH) biomechanics are associated with glaucoma progression and have received considerable attention. Central retinal vessels (CRVs) oriented asymmetrically in the ONH are the single blood supply source to the retina and are believed to act as mechanically stable elements in the ONH in response to intraocular pressure (IOP). However, these mechanical effects are considered negligible in ONH biomechanical studies and received less attention. This study investigated the effects of CRVs on ONH biomechanics taking into consideration three-dimensional asymmetric CRV geometries. A CRV geometry was constructed based on CRV centerlines extracted from optical coherence tomography ONH images in eight healthy subjects and superimposed in the idealized ONH geometry established in previous studies. Mechanical analyses of the ONH in response to the IOP were conducted in the cases with and without CRVs for comparison. Obtained results demonstrated that the CRVs induced anisotropic ONH deformation, particularly in the lamina cribrosa and the associated upper neural tissues (prelamina) with wide ranges of spatial strain distributions. These results indicated that the CRVs result in anisotropic deformation with local strain concentration, rather than function to mechanically support in response to the IOP as in the conventional thinking in ophthalmology.
出版者	Elsevier Ltd
収録物名	Medical Engineering and Physics
巻(号)	123
ページ	104086
刊行年月	2024-01-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93456
PISSN	13504533
eISSN	18734030
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1016/j.medengphy.2023.104086
アクセス権	open access
権利情報	© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Medical Engineering and Physics. 2024, 123, p. 104086
DC.title	Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics
DC.creator	Otani, Tomohiro
	Miyata, Kota
	Miki, Atsuya
	Wada, Shigeo
DC.publisher	Elsevier Ltd
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-01-01
DC.identifier	https://doi.org/10.1016/j.medengphy.2023.104086
DC.subject	Central retinal vessel
	Glaucoma
	Optic nerves head
	Optical coherence tomography
	Smoothed finite element method
DC.description	Otani T., Miyata K., Miki A., et al. Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics. Medical Engineering and Physics 123, 104086 (2024); https://doi.org/10.1016/j.medengphy.2023.104086.
DCTERMS.abstract	Optic nerve head (ONH) biomechanics are associated with glaucoma progression and have received considerable attention. Central retinal vessels (CRVs) oriented asymmetrically in the ONH are the single blood supply source to the retina and are believed to act as mechanically stable elements in the ONH in response to intraocular pressure (IOP). However, these mechanical effects are considered negligible in ONH biomechanical studies and received less attention. This study investigated the effects of CRVs on ONH biomechanics taking into consideration three-dimensional asymmetric CRV geometries. A CRV geometry was constructed based on CRV centerlines extracted from optical coherence tomography ONH images in eight healthy subjects and superimposed in the idealized ONH geometry established in previous studies. Mechanical analyses of the ONH in response to the IOP were conducted in the cases with and without CRVs for comparison. Obtained results demonstrated that the CRVs induced anisotropic ONH deformation, particularly in the lamina cribrosa and the associated upper neural tissues (prelamina) with wide ranges of spatial strain distributions. These results indicated that the CRVs result in anisotropic deformation with local strain concentration, rather than function to mechanically support in response to the IOP as in the conventional thinking in ophthalmology.
DC.rights	© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.format	93456
citation_title	Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics
citation_author	Otani, Tomohiro
	Miyata, Kota
	Miki, Atsuya
	Wada, Shigeo
citation_publisher	Elsevier Ltd
citation_language	英語
citation_date	2024-01-01
citation_journal_title	Medical Engineering and Physics
citation_volume	123
citation_firstpage	104086
citation_doi	https://doi.org/10.1016/j.medengphy.2023.104086
citation_public_url	https://hdl.handle.net/11094/93456

Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics

閲覧可能ファイル

論文情報

論文詳細を表示