学術雑誌論文

学術雑誌論文

text

Communications Biology. 2023, 6(1), p. 1287

Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways

Nature Research

英語

text

2023-12-20

https://doi.org/10.1038/S42003-023-05660-X

Suyama R., Cetraro N., Yew J.Y., et al. Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways. Communications Biology 6, 1287 (2023); https://doi.org/10.1038/S42003-023-05660-X.

Reproduction is highly dependent on environmental and physiological factors including nutrition, mating stimuli and microbes. Among these factors, microbes facilitate vital functions for host animals such as nutritional intake, metabolic regulation, and enhancing fertility under poor nutrition conditions. However, detailed molecular mechanisms by which microbes control germline maturation, leading to reproduction, remain largely unknown. In this study, we show that environmental microbes exert a beneficial effect on Drosophila oogenesis by promoting germline stem cell (GSC) proliferation and subsequent egg maturation via acceleration of ovarian cell division and suppression of apoptosis. Moreover, insulin-related signaling is not required; rather, the ecdysone pathway is necessary for microbe-induced increase of GSCs and promotion of egg maturation, while juvenile hormone contributes only to increasing GSC numbers, suggesting that hormonal pathways are activated at different stages of oogenesis. Our findings reveal that environmental microbes can enhance host reproductivity by modulating host hormone release and promoting oogenesis.

This article is licensed under a Creative Commons Attribution 4.0 International License.

93535

Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways

Nature Research

英語

2023-12-20

Communications Biology

6

1

1287

https://doi.org/10.1038/S42003-023-05660-X

https://hdl.handle.net/11094/93535