The impact of contour maps on estimating the risk of gastrointestinal stromal tumor recurrence: indications for adjuvant therapy: an analysis of the Kinki GIST registry

Teranishi, Ryugo; Takahashi, Tsuyoshi; Sato, Shinsuke; Sakurai, Katsunobu; Kishi, Kentaro; Hosogi, Hisahiro; Nakai, Takuya; Kurokawa, Yukinori; Fujita, Junya; Nishida, Toshirou; Hirota, Seiichi; Tsujinaka, Toshimasa

doi:https://doi.org/10.1007/s10120-023-01444-8

The impact of contour maps on estimating the risk of gastrointestinal stromal tumor recurrence: indications for adjuvant therapy: an analysis of the Kinki GIST registry

Teranishi, Ryugo; Takahashi, Tsuyoshi; Sato, Shinsuke et al.

Gastric Cancer, 2023, 27, 355-365

アクセス数:921件（2025-09-01 11:37 集計）

固定URL: https://hdl.handle.net/11094/93545

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タイトル	The impact of contour maps on estimating the risk of gastrointestinal stromal tumor recurrence: indications for adjuvant therapy: an analysis of the Kinki GIST registry
著者	著者名 Teranishi, Ryugo
	NRID 1000050452389 1000050452389 ORCID 0000-0003-2397-1478 0000-0003-2397-1478 researchmap permalink mihogaoka13611 mihogaoka13611 Scopus Author ID 56182761100 56182761100 著者名 Takahashi, Tsuyoshi
	著者名 Sato, Shinsuke
	著者名 Sakurai, Katsunobu
	著者名 Kishi, Kentaro
	著者名 Hosogi, Hisahiro
	NRID 1000060227725 1000060227725 著者名 Nakai, Takuya
	NRID 1000010470197 1000010470197 researchmap permalink krkw krkw Scopus Author ID 7202562410 7202562410 著者名 Kurokawa, Yukinori
	著者名 Fujita, Junya
	著者名 Nishida, Toshirou
	NRID 1000050218856 1000050218856 著者名 Hirota, Seiichi
	著者名 Tsujinaka, Toshimasa
キーワード等	Adjuvant therapy
	Contour maps
	Gastrointestinal stromal tumors
	Imatinib
	Stomach
内容	The version of record of this article, first published in Gastric Cancer, is available online at Publisher’s website: https://doi.org/10.1007/s10120-023-01444-8
抄録	Introduction: Contour maps enable risk classification of GIST recurrence in individual patients within 10 postoperative years. Although contour maps have been referred to in Japanese guidelines, their usefulness and role in determining indications for adjuvant therapy is still unclear in Japanese patients. The aims of this study are to investigate the validity of contour maps in Japanese patients with GIST and explore the new strategy for adjuvant therapy. Materials and methods: A total of 1426 Japanese GIST patients who were registered to the registry by the Kinki GIST Study Group between 2003 and 2012 were analyzed. Patients who had R0 surgery without perioperative therapy were included in this study. The accuracy of contour maps was validated. Results: Overall, 994 patients have concluded this study. Using contour maps, we validated the patients. The 5-year recurrence-free survival rates of patients within the GIST classification groups of 0–10%, 10–20%, 20–40%, 40–60%, 60–80%, 80–90%, and 90–100% were 98.1%, 96.6%, 92.3%, 48.0%, 37.3%, 41.0% and 42.4%, respectively. We confirmed that this classification by contour maps was well reflected recurrence prediction. Further, in the high-risk group stratified by the modified National Institutes of Health consensus criteria (m-NIHC), the 10-year RFS rate was remarkably changed at a cutoff of 40% (0–40% group vs. 40–100% group: 88.7% vs. 50.3%, p < 0.001). Conclusion: Contour maps are effective in predicting individual recurrence rates. And it may be useful for the decision of individual strategy for high-risk patients combined with m-NIHC.
出版者	Springer
収録物名	Gastric Cancer
巻(号)	27
ページ	355-365
刊行年月	2023-12-25
言語	英語
ハンドルURL	https://hdl.handle.net/11094/93545
PISSN	14363291
eISSN	14363305
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s10120-023-01444-8
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Gastric Cancer. 2023, 27, p. 355-365
DC.title	The impact of contour maps on estimating the risk of gastrointestinal stromal tumor recurrence: indications for adjuvant therapy: an analysis of the Kinki GIST registry
DC.creator	Teranishi, Ryugo
	Takahashi, Tsuyoshi
	Sato, Shinsuke
	Sakurai, Katsunobu
	Kishi, Kentaro
	Hosogi, Hisahiro
	Nakai, Takuya
	Kurokawa, Yukinori
	Fujita, Junya
	Nishida, Toshirou
	Hirota, Seiichi
	Tsujinaka, Toshimasa
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-12-25
DC.identifier	https://doi.org/10.1007/s10120-023-01444-8
DC.subject	Adjuvant therapy
	Contour maps
	Gastrointestinal stromal tumors
	Imatinib
	Stomach
DC.description	The version of record of this article, first published in Gastric Cancer, is available online at Publisher’s website: https://doi.org/10.1007/s10120-023-01444-8
DCTERMS.abstract	Introduction: Contour maps enable risk classification of GIST recurrence in individual patients within 10 postoperative years. Although contour maps have been referred to in Japanese guidelines, their usefulness and role in determining indications for adjuvant therapy is still unclear in Japanese patients. The aims of this study are to investigate the validity of contour maps in Japanese patients with GIST and explore the new strategy for adjuvant therapy. Materials and methods: A total of 1426 Japanese GIST patients who were registered to the registry by the Kinki GIST Study Group between 2003 and 2012 were analyzed. Patients who had R0 surgery without perioperative therapy were included in this study. The accuracy of contour maps was validated. Results: Overall, 994 patients have concluded this study. Using contour maps, we validated the patients. The 5-year recurrence-free survival rates of patients within the GIST classification groups of 0–10%, 10–20%, 20–40%, 40–60%, 60–80%, 80–90%, and 90–100% were 98.1%, 96.6%, 92.3%, 48.0%, 37.3%, 41.0% and 42.4%, respectively. We confirmed that this classification by contour maps was well reflected recurrence prediction. Further, in the high-risk group stratified by the modified National Institutes of Health consensus criteria (m-NIHC), the 10-year RFS rate was remarkably changed at a cutoff of 40% (0–40% group vs. 40–100% group: 88.7% vs. 50.3%, p < 0.001). Conclusion: Contour maps are effective in predicting individual recurrence rates. And it may be useful for the decision of individual strategy for high-risk patients combined with m-NIHC.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93545
citation_title	The impact of contour maps on estimating the risk of gastrointestinal stromal tumor recurrence: indications for adjuvant therapy: an analysis of the Kinki GIST registry
citation_author	Teranishi, Ryugo
	Takahashi, Tsuyoshi
	Sato, Shinsuke
	Sakurai, Katsunobu
	Kishi, Kentaro
	Hosogi, Hisahiro
	Nakai, Takuya
	Kurokawa, Yukinori
	Fujita, Junya
	Nishida, Toshirou
	Hirota, Seiichi
	Tsujinaka, Toshimasa
citation_publisher	Springer
citation_language	英語
citation_date	2023-12-25
citation_journal_title	Gastric Cancer
citation_volume	27
citation_firstpage	355
citation_lastpage	365
citation_doi	https://doi.org/10.1007/s10120-023-01444-8
citation_public_url	https://hdl.handle.net/11094/93545

The impact of contour maps on estimating the risk of gastrointestinal stromal tumor recurrence: indications for adjuvant therapy: an analysis of the Kinki GIST registry

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