学術雑誌論文

学術雑誌論文

text

Organic Letters. 2023, 25(18), p. 3206-3209

Rhodium-Catalyzed Isoquinoline Synthesis Using Vinyl Selenone as Oxidizing Acetylene Surrogate

American Chemical Society

英語

text

2023-05-12

https://doi.org/10.1021/acs.orglett.3c00826

Inami A., Nishii Y., Hirano K., et al. Rhodium-Catalyzed Isoquinoline Synthesis Using Vinyl Selenone as Oxidizing Acetylene Surrogate. Organic Letters 25, 3206 (2023); https://doi.org/10.1021/acs.orglett.3c00826.

Isoquinoline is a privileged structure in many bioactive compounds and valuable ligands. Transition-metal-catalyzed oxidative annulation of imine derivatives has become a promising synthetic method; however, catalytic synthesis of 3,4-nonsubstituted isoquinolines by formal acetylene annulation has been scarce to date. Herein, we introduce vinyl selenone as an effective acetylene surrogate for the Rh-catalyzed annulative coupling under mild conditions. The Se fragment can be recovered as diselenide and recycled. The product can readily be converted to 1-aminoisoquinolines.

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.3c00826.

94008

Rhodium-Catalyzed Isoquinoline Synthesis Using Vinyl Selenone as Oxidizing Acetylene Surrogate

American Chemical Society

英語

2023-05-12

Organic Letters

25

18

3206

3209

https://doi.org/10.1021/acs.orglett.3c00826

https://hdl.handle.net/11094/94008