Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study

Kawano, Tomohiro; Gon, Yasufumi; Sakaguchi, Manabu; Yamagami, Hiroshi; Abe, Soichiro; Hashimoto, Hiroyuki; Ohara, Nobuyuki; Takahashi, Daisuke; Abe, Yuko; Takahashi, Tsutomu; Okazaki, Shuhei; Todo, Kenichi; Mochizuki, Hideki; Sasaki, Tsutomu

doi:https://doi.org/10.1161/JAHA.123.032284

Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study

Kawano, Tomohiro; Gon, Yasufumi; Sakaguchi, Manabu et al.

Journal of the American Heart Association, 2024, 13(3), e032284

アクセス数:1,644件（2025-09-01 14:41 集計）

固定URL: https://hdl.handle.net/11094/94592

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
JAmHeartAssoc_13_3_e032284	pdf	なし	575 KB	99	2024.03.04

Creative Commons : 表示 - 非営利 - 改変禁止

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study
著者	著者名 Kawano, Tomohiro
	NRID 1000070751311 1000070751311 researchmap permalink y-gon y-gon Scopus Author ID 56565092900 56565092900 著者名 Gon, Yasufumi
	NRID 1000070432474 1000070432474 著者名 Sakaguchi, Manabu
	NRID 1000000455552 1000000455552 著者名 Yamagami, Hiroshi
	著者名 Abe, Soichiro
	著者名 Hashimoto, Hiroyuki
	著者名 Ohara, Nobuyuki
	著者名 Takahashi, Daisuke
	著者名 Abe, Yuko
	著者名 Takahashi, Tsutomu
	NRID 1000060623072 1000060623072 著者名 Okazaki, Shuhei
	NRID 1000040403068 1000040403068 researchmap permalink kenichitodo kenichitodo Scopus Author ID 22954718500 22954718500 著者名 Todo, Kenichi
	NRID 1000090230044 1000090230044 ORCID 0000-0002-0874-7542 0000-0002-0874-7542 researchmap permalink read0207787 read0207787 Scopus Author ID 7202006099 7202006099 著者名 Mochizuki, Hideki
	NRID 1000020534879 1000020534879 ORCID 0000-0001-8726-978X 0000-0001-8726-978X researchmap permalink tsutomusasaki1111 tsutomusasaki1111 Scopus Author ID 7407394272 7407394272 著者名 Sasaki, Tsutomu
キーワード等	active cancer
	cancer‐associated stroke
	ischemic stroke
	von Willebrand factor antigen levels
内容	Kawano T., Gon Y., Sakaguchi M., et al. Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study. Journal of the American Heart Association 13, e032284 (2024); https://doi.org/10.1161/JAHA.123.032284.
抄録	BACKGROUND: Patients with acute ischemic stroke and active cancer have more severe neurological symptoms, elevated risks of stroke recurrence, and death compared with the general population. We examined whether von Willebrand factor (vWF) antigen levels at stroke onset were associated with the poor outcomes of patients with stroke and cancer. METHODS AND RESULTS: Using data from 90 patients with acute ischemic stroke and active cancer who were registered in the SCAN (Ischemic Stroke in Patients With Cancer and Neoplasia) study, a prospective multicenter, observational study in Japan, we divided patients into 2 groups according to their median vWF antigen levels (high, n=46; or low, n=44). The high-vWF group had a significantly higher initial National Institutes of Health Stroke Scale score (median, 7 [interquartile range, 3-11.25] versus 3 [interquartile range, 1-8.5]; P<0.05) and a significantly higher incidence of cryptogenic stroke (32 [70%] versus 16 [36%]; P<0.01) and venous thromboembolism (7 [15%] versus 0 [0%]; P<0.01), as well as multiple lesions (28 [62%] versus 12 [27%]; P<0.001), than the low-vWF group. We observed no significant difference in the rate of stroke recurrence within 1 year between the groups. However, increased vWF levels were an independent predictor of death within 1 year of stroke onset, after adjusting for potential confounders (odds ratio, 6.77 [95% CI, 1.49-30.78]; P<0.05). CONCLUSIONS: Elevated vWF antigen levels were associated with adverse outcomes in patients with cancer-associated stroke and may represent a useful biomarker to guide future therapeutic interventions.
出版者	AHA (American Heart Association)
収録物名	Journal of the American Heart Association
巻(号)	13(3)
ページ	e032284
刊行年月	2024-02-06
言語	英語
ハンドルURL	https://hdl.handle.net/11094/94592
eISSN	20479980
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1161/JAHA.123.032284
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of the American Heart Association. 2024, 13(3), p. e032284
DC.title	Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study
DC.creator	Kawano, Tomohiro
	Gon, Yasufumi
	Sakaguchi, Manabu
	Yamagami, Hiroshi
	Abe, Soichiro
	Hashimoto, Hiroyuki
	Ohara, Nobuyuki
	Takahashi, Daisuke
	Abe, Yuko
	Takahashi, Tsutomu
	Okazaki, Shuhei
	Todo, Kenichi
	Mochizuki, Hideki
	Sasaki, Tsutomu
DC.publisher	AHA (American Heart Association)
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-02-06
DC.identifier	https://doi.org/10.1161/JAHA.123.032284
DC.subject	active cancer
	cancer‐associated stroke
	ischemic stroke
	von Willebrand factor antigen levels
DC.description	Kawano T., Gon Y., Sakaguchi M., et al. Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study. Journal of the American Heart Association 13, e032284 (2024); https://doi.org/10.1161/JAHA.123.032284.
DCTERMS.abstract	BACKGROUND: Patients with acute ischemic stroke and active cancer have more severe neurological symptoms, elevated risks of stroke recurrence, and death compared with the general population. We examined whether von Willebrand factor (vWF) antigen levels at stroke onset were associated with the poor outcomes of patients with stroke and cancer. METHODS AND RESULTS: Using data from 90 patients with acute ischemic stroke and active cancer who were registered in the SCAN (Ischemic Stroke in Patients With Cancer and Neoplasia) study, a prospective multicenter, observational study in Japan, we divided patients into 2 groups according to their median vWF antigen levels (high, n=46; or low, n=44). The high-vWF group had a significantly higher initial National Institutes of Health Stroke Scale score (median, 7 [interquartile range, 3-11.25] versus 3 [interquartile range, 1-8.5]; P<0.05) and a significantly higher incidence of cryptogenic stroke (32 [70%] versus 16 [36%]; P<0.01) and venous thromboembolism (7 [15%] versus 0 [0%]; P<0.01), as well as multiple lesions (28 [62%] versus 12 [27%]; P<0.001), than the low-vWF group. We observed no significant difference in the rate of stroke recurrence within 1 year between the groups. However, increased vWF levels were an independent predictor of death within 1 year of stroke onset, after adjusting for potential confounders (odds ratio, 6.77 [95% CI, 1.49-30.78]; P<0.05). CONCLUSIONS: Elevated vWF antigen levels were associated with adverse outcomes in patients with cancer-associated stroke and may represent a useful biomarker to guide future therapeutic interventions.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	94592
citation_title	Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study
citation_author	Kawano, Tomohiro
	Gon, Yasufumi
	Sakaguchi, Manabu
	Yamagami, Hiroshi
	Abe, Soichiro
	Hashimoto, Hiroyuki
	Ohara, Nobuyuki
	Takahashi, Daisuke
	Abe, Yuko
	Takahashi, Tsutomu
	Okazaki, Shuhei
	Todo, Kenichi
	Mochizuki, Hideki
	Sasaki, Tsutomu
citation_publisher	AHA (American Heart Association)
citation_language	英語
citation_date	2024-02-06
citation_journal_title	Journal of the American Heart Association
citation_volume	13
citation_issue	3
citation_firstpage	e032284
citation_doi	https://doi.org/10.1161/JAHA.123.032284
citation_public_url	https://hdl.handle.net/11094/94592

Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study

閲覧可能ファイル

論文情報

論文詳細を表示