Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats

Katagiri, Ayano; Yamada, Masaharu; Sato, Hajime; Toyoda, Hiroki; Niwa, Hitoshi; Kato, Takafumi

doi:https://doi.org/10.1007/s10266-023-00887-w

Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats

Katagiri, Ayano; Yamada, Masaharu; Sato, Hajime et al.

Odontology, 2024, 112(3), 906-916

アクセス数:874件（2025-07-26 07:09 集計）

固定URL: https://hdl.handle.net/11094/94639

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タイトル	Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats
著者	NRID 1000040731899 1000040731899 ORCID 0000-0001-7381-8557 0000-0001-7381-8557 researchmap permalink katagiri-ayano katagiri-ayano Scopus Author ID 47161239400 47161239400 著者名 Katagiri, Ayano
	著者名 Yamada, Masaharu
	NRID 1000010432452 1000010432452 著者名 Sato, Hajime
	NRID 1000000432451 1000000432451 ORCID 0000-0002-9907-7176 0000-0002-9907-7176 researchmap permalink read0210128 read0210128 Scopus Author ID 8708646300 8708646300 著者名 Toyoda, Hiroki
	NRID 1000030218250 1000030218250 researchmap permalink 19580710 19580710 Scopus Author ID 24351577000 24351577000 著者名 Niwa, Hitoshi
	NRID 1000050367520 1000050367520 ORCID 0000-0003-2452-7328 0000-0003-2452-7328 researchmap permalink read0111598_hrfc15 read0111598_hrfc15 Scopus Author ID 57210579311 57210579311 著者名 Kato, Takafumi
キーワード等	Hypoxic stress
	Intraoral hypersensitivity
	Masticatory function
	Maternal separation
	Suckling-mastication transition period
内容	The version of record of this article, first published in Odontology, is available online at Publisher’s website: https://doi.org/10.1007/s10266-023-00887-w.
抄録	Early-life stress affects brain development, eventually resulting in adverse behavioral and physical health consequences in adulthood. The present study assessed the hypothesis that short-term early-life stress during infancy before weaning, a period for the maturation of mastication and sleep, poses long-lasting adverse effects on masticatory function and intraoral sensations later in life. Rat pups were exposed to either maternal separation (MS) or intermittent hypoxia (IH-Infancy) for 6 h/day in the light/sleep phase from postnatal day (P)17 to P20 to generate “neglect” and “pediatric obstructive sleep apnea” models, respectively. The remaining rats were exposed to IH during P45–P48 (IH-Adult). Masticatory ability was evaluated based on the rats’ ability to chew pellets and bite pasta throughout the growth period (P21–P70). Intraoral chemical and mechanical sensitivities were assessed using two-bottle preference drinking tests, and hind paw pain thresholds were measured in adulthood (after P60). No differences were found in body weight, grip force, and hind paw sensitivity in MS, IH-Infancy, and IH-Adult rats compared with naïve rats. Masticatory ability was lower in MS and IH-Infancy rats from P28 to P70 than in naïve rats. MS and IH-Infancy rats exhibited intraoral hypersensitivity to capsaicin and mechanical stimulations in adulthood. The IH-Adult rats did not display inferior masticatory ability or intraoral hypersensitivity. In conclusion, short-term early-life stress during the suckling–mastication transition period potentially causes a persistent decrease in masticatory ability and intraoral hypersensitivity in adulthood. The period is a “critical window” for the maturation of oral motor and sensory functions.
出版者	Springer
収録物名	Odontology
巻(号)	112(3)
ページ	906-916
刊行年月	2024-01-10
言語	英語
ハンドルURL	https://hdl.handle.net/11094/94639
PISSN	16181247
eISSN	16181255
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s10266-023-00887-w
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Odontology. 2024, 112(3), p. 906-916
DC.title	Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats
DC.creator	Katagiri, Ayano
	Yamada, Masaharu
	Sato, Hajime
	Toyoda, Hiroki
	Niwa, Hitoshi
	Kato, Takafumi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-01-10
DC.identifier	https://doi.org/10.1007/s10266-023-00887-w
DC.subject	Hypoxic stress
	Intraoral hypersensitivity
	Masticatory function
	Maternal separation
	Suckling-mastication transition period
DC.description	The version of record of this article, first published in Odontology, is available online at Publisher’s website: https://doi.org/10.1007/s10266-023-00887-w.
DCTERMS.abstract	Early-life stress affects brain development, eventually resulting in adverse behavioral and physical health consequences in adulthood. The present study assessed the hypothesis that short-term early-life stress during infancy before weaning, a period for the maturation of mastication and sleep, poses long-lasting adverse effects on masticatory function and intraoral sensations later in life. Rat pups were exposed to either maternal separation (MS) or intermittent hypoxia (IH-Infancy) for 6 h/day in the light/sleep phase from postnatal day (P)17 to P20 to generate “neglect” and “pediatric obstructive sleep apnea” models, respectively. The remaining rats were exposed to IH during P45–P48 (IH-Adult). Masticatory ability was evaluated based on the rats’ ability to chew pellets and bite pasta throughout the growth period (P21–P70). Intraoral chemical and mechanical sensitivities were assessed using two-bottle preference drinking tests, and hind paw pain thresholds were measured in adulthood (after P60). No differences were found in body weight, grip force, and hind paw sensitivity in MS, IH-Infancy, and IH-Adult rats compared with naïve rats. Masticatory ability was lower in MS and IH-Infancy rats from P28 to P70 than in naïve rats. MS and IH-Infancy rats exhibited intraoral hypersensitivity to capsaicin and mechanical stimulations in adulthood. The IH-Adult rats did not display inferior masticatory ability or intraoral hypersensitivity. In conclusion, short-term early-life stress during the suckling–mastication transition period potentially causes a persistent decrease in masticatory ability and intraoral hypersensitivity in adulthood. The period is a “critical window” for the maturation of oral motor and sensory functions.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	94639
citation_title	Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats
citation_author	Katagiri, Ayano
	Yamada, Masaharu
	Sato, Hajime
	Toyoda, Hiroki
	Niwa, Hitoshi
	Kato, Takafumi
citation_publisher	Springer
citation_language	英語
citation_date	2024-01-10
citation_journal_title	Odontology
citation_volume	112
citation_issue	3
citation_firstpage	906
citation_lastpage	916
citation_doi	https://doi.org/10.1007/s10266-023-00887-w
citation_public_url	https://hdl.handle.net/11094/94639

Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats

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