Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study

Saito, Takuro; Kurokawa, Yukinori; Fujitani, Kazumasa; Kawabata, Ryohei; Takeno, Atsushi; Mikami, Jota; Endo, Shunji; Matsuyama, Jin; Akamaru, Yusuke; Hirota, Masashi; Kishi, Kentaro; Urakawa, Shinya; Yamamoto, Kei; Tanaka, Koji; Takahashi, Tsuyoshi; Oka, Mikio; Wada, Hisashi; Eguchi, Hidetoshi; Doki, Yuichiro

doi:https://doi.org/10.1038/s41416-023-02540-3

Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study

Saito, Takuro; Kurokawa, Yukinori; Fujitani, Kazumasa et al.

British Journal of Cancer, 2024, 130, 1157-1165

アクセス数:83件（2025-04-28 19:51 集計）

固定URL: https://hdl.handle.net/11094/94644

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タイトル	Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study
著者	NRID 1000020646468 1000020646468 researchmap permalink tsaito19 tsaito19 Scopus Author ID 57211629912 57211629912 著者名 Saito, Takuro
	NRID 1000010470197 1000010470197 researchmap permalink krkw krkw Scopus Author ID 7202562410 7202562410 著者名 Kurokawa, Yukinori
	著者名 Fujitani, Kazumasa
	著者名 Kawabata, Ryohei
	著者名 Takeno, Atsushi
	著者名 Mikami, Jota
	著者名 Endo, Shunji
	著者名 Matsuyama, Jin
	著者名 Akamaru, Yusuke
	著者名 Hirota, Masashi
	著者名 Kishi, Kentaro
	NRID 1000040768975 1000040768975 researchmap permalink surakawa-surakawa surakawa-surakawa 著者名 Urakawa, Shinya
	NRID 1000090835240 1000090835240 著者名 Yamamoto, Kei
	NRID 1000070621019 1000070621019 ORCID 0000-0001-5178-9388 0000-0001-5178-9388 researchmap permalink koji_tanaka koji_tanaka Scopus Author ID 55628548952 55628548952 著者名 Tanaka, Koji
	NRID 1000050452389 1000050452389 ORCID 0000-0003-2397-1478 0000-0003-2397-1478 researchmap permalink mihogaoka13611 mihogaoka13611 Scopus Author ID 56182761100 56182761100 著者名 Takahashi, Tsuyoshi
	NRID 1000040223995 1000040223995 著者名 Oka, Mikio
	NRID 1000070243459 1000070243459 researchmap permalink hwada hwada Scopus Author ID 7402917501 7402917501 著者名 Wada, Hisashi
	NRID 1000090542118 1000090542118 researchmap permalink abcdabcdabcd abcdabcdabcd Scopus Author ID 7101627772 7101627772 著者名 Eguchi, Hidetoshi
	NRID 1000020291445 1000020291445 researchmap permalink ydoki3251 ydoki3251 Scopus Author ID 7006390687 7006390687 著者名 Doki, Yuichiro
内容	The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: https://doi.org/10.1038/s41416-023-02540-3
抄録	Background: No reliable marker has been identified to predict postoperative recurrence of gastric cancer. We designed a clinical trial to investigate the utility of serum NY-ESO-1 antibody responses as a predictive marker for postoperative recurrence in gastric cancer. Methods: A multicenter prospective study was conducted between 2012 and 2021. Patients with resectable cT3-4 gastric cancer were included. Postoperative NY-ESO-1 and p53 antibody responses were serially evaluated every 3 months for 1 year in patients with positive preoperative antibody responses. The recurrence rate was assessed by the positivity of antibody responses at 3 and 12 months postoperatively. Results: Among 1001 patients, preoperative NY-ESO-1 and p53 antibody responses were positive in 12.6% and 18.1% of patients, respectively. NY-ESO-1 antibody responses became negative postoperatively in non-recurrent patients (negativity rates; 45% and 78% at 3 and 12 months, respectively), but remained positive in recurrent patients (negativity rates; 9% and 8%, respectively). p53 antibody responses remained positive in non-recurrent patients. In multivariate analysis, NY-ESO-1 antibody positivity at 3 months (P < 0.03) and 12 months (P < 0.001) were independent prognostic factors for a shorter recurrence-free interval. Conclusions: Serum NY-ESO-1 antibodies may be a useful predictive marker for postoperative recurrence in gastric cancer. Clinical trial registration: UMIN000007925.
出版者	Springer Nature
収録物名	British Journal of Cancer
巻(号)	130
ページ	1157-1165
刊行年月	2024-02-07
言語	英語
ハンドルURL	https://hdl.handle.net/11094/94644
PISSN	00070920
eISSN	15321827
関連情報
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41416-023-02540-3
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	British Journal of Cancer. 2024, 130, p. 1157-1165
DC.title	Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study
DC.creator	Saito, Takuro
	Kurokawa, Yukinori
	Fujitani, Kazumasa
	Kawabata, Ryohei
	Takeno, Atsushi
	Mikami, Jota
	Endo, Shunji
	Matsuyama, Jin
	Akamaru, Yusuke
	Hirota, Masashi
	Kishi, Kentaro
	Urakawa, Shinya
	Yamamoto, Kei
	Tanaka, Koji
	Takahashi, Tsuyoshi
	Oka, Mikio
	Wada, Hisashi
	Eguchi, Hidetoshi
	Doki, Yuichiro
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-02-07
DC.identifier	https://doi.org/10.1038/s41416-023-02540-3
DC.description	The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: https://doi.org/10.1038/s41416-023-02540-3
DCTERMS.abstract	Background: No reliable marker has been identified to predict postoperative recurrence of gastric cancer. We designed a clinical trial to investigate the utility of serum NY-ESO-1 antibody responses as a predictive marker for postoperative recurrence in gastric cancer. Methods: A multicenter prospective study was conducted between 2012 and 2021. Patients with resectable cT3-4 gastric cancer were included. Postoperative NY-ESO-1 and p53 antibody responses were serially evaluated every 3 months for 1 year in patients with positive preoperative antibody responses. The recurrence rate was assessed by the positivity of antibody responses at 3 and 12 months postoperatively. Results: Among 1001 patients, preoperative NY-ESO-1 and p53 antibody responses were positive in 12.6% and 18.1% of patients, respectively. NY-ESO-1 antibody responses became negative postoperatively in non-recurrent patients (negativity rates; 45% and 78% at 3 and 12 months, respectively), but remained positive in recurrent patients (negativity rates; 9% and 8%, respectively). p53 antibody responses remained positive in non-recurrent patients. In multivariate analysis, NY-ESO-1 antibody positivity at 3 months (P < 0.03) and 12 months (P < 0.001) were independent prognostic factors for a shorter recurrence-free interval. Conclusions: Serum NY-ESO-1 antibodies may be a useful predictive marker for postoperative recurrence in gastric cancer. Clinical trial registration: UMIN000007925.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	94644
citation_title	Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study
citation_author	Saito, Takuro
	Kurokawa, Yukinori
	Fujitani, Kazumasa
	Kawabata, Ryohei
	Takeno, Atsushi
	Mikami, Jota
	Endo, Shunji
	Matsuyama, Jin
	Akamaru, Yusuke
	Hirota, Masashi
	Kishi, Kentaro
	Urakawa, Shinya
	Yamamoto, Kei
	Tanaka, Koji
	Takahashi, Tsuyoshi
	Oka, Mikio
	Wada, Hisashi
	Eguchi, Hidetoshi
	Doki, Yuichiro
citation_publisher	Springer Nature
citation_language	英語
citation_date	2024-02-07
citation_journal_title	British Journal of Cancer
citation_volume	130
citation_firstpage	1157
citation_lastpage	1165
citation_doi	https://doi.org/10.1038/s41416-023-02540-3
citation_public_url	https://hdl.handle.net/11094/94644

Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study

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