学術雑誌論文

学術雑誌論文

text

Molecular Psychiatry. 2024, 29, p. 1406-1416

(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice

Springer Nature

英語

text

2024-02-23

https://doi.org/10.1038/s41380-024-02419-6

Yokoyama R., Ago Y., Igarashi H., et al. (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice. Molecular Psychiatry , (2024); https://doi.org/10.1038/s41380-024-02419-6.

Chronic social isolation increases the risk of mental health problems, including cognitive impairments and depression. While subanesthetic ketamine is considered effective for cognitive impairments in patients with depression, the neural mechanisms underlying its effects are not well understood. Here we identified unique activation of the anterior insular cortex (aIC) as a characteristic feature in brain-wide regions of mice reared in social isolation and treated with (R)-ketamine, a ketamine enantiomer. Using fiber photometry recording on freely moving mice, we found that social isolation attenuates aIC neuronal activation upon social contact and that (R)-ketamine, but not (S)-ketamine, is able to counteracts this reduction. (R)-ketamine facilitated social cognition in social isolation-reared mice during the social memory test. aIC inactivation offset the effect of (R)-ketamine on social memory. Our results suggest that (R)-ketamine has promising potential as an effective intervention for social cognitive deficits by restoring aIC function.

This article is licensed under a Creative Commons Attribution 4.0 International License.

94697

(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice

Springer Nature

英語

2024-02-23

Molecular Psychiatry

29

1406

1416

https://doi.org/10.1038/s41380-024-02419-6

https://hdl.handle.net/11094/94697