Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma

Tatsumi, Mitsuaki; Tanaka, Hidenori; Takenaka, Yukinori; Suzuki, Motoyuki; Fukusumi, Takahito; Eguchi, Hirotaka; Watabe, Tadashi; Kato, Hiroki; Yachida, Shinichi; Inohara, Hidenori; Tomiyama, Noriyuki

doi:https://doi.org/10.1038/s41598-024-53894-4

Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma

Tatsumi, Mitsuaki; Tanaka, Hidenori; Takenaka, Yukinori et al.

Scientific Reports, 2024, 14(1), 3278

アクセス数:1,893件（2025-07-28 14:31 集計）

固定URL: https://hdl.handle.net/11094/94886

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
SciRep_14_1_3278	pdf	なし	1.31 MB	98	2024.04.08

Creative Commons : 表示

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma
著者	NRID 1000060397700 1000060397700 ORCID 0000-0003-1778-0421 0000-0003-1778-0421 researchmap permalink mtatsumi mtatsumi Scopus Author ID 7102266657 7102266657 著者名 Tatsumi, Mitsuaki
	NRID 1000000804379 1000000804379 ORCID 0000-0002-7516-9180 0000-0002-7516-9180 researchmap permalink hidenoritanaka hidenoritanaka 著者名 Tanaka, Hidenori
	NRID 1000040598398 1000040598398 ORCID 0000-0002-3135-5635 0000-0002-3135-5635 researchmap permalink yukinoritakenaka yukinoritakenaka Scopus Author ID 7102054128 7102054128 著者名 Takenaka, Yukinori
	NRID 1000050632329 1000050632329 researchmap permalink motoyukisuzuki motoyukisuzuki Scopus Author ID 55505806400 55505806400 著者名 Suzuki, Motoyuki
	NRID 1000070623734 1000070623734 researchmap permalink 2933 2933 Scopus Author ID 54893429600 54893429600 ORCID 0009-0002-1857-7548 0009-0002-1857-7548 著者名 Fukusumi, Takahito
	researchmap permalink eguchi-hirotaka eguchi-hirotaka Scopus Author ID 57203344374 57203344374 NRID 1000090844936 1000090844936 著者名 Eguchi, Hirotaka
	NRID 1000090648932 1000090648932 ORCID 0000-0001-8658-2395 0000-0001-8658-2395 researchmap permalink twosaka2018 twosaka2018 Scopus Author ID 57421862900 57421862900 著者名 Watabe, Tadashi
	著者名 Kato, Hiroki
	NRID 1000020359920 1000020359920 researchmap permalink read0210591 read0210591 Scopus Author ID 57226203270 57226203270 著者名 Yachida, Shinichi
	NRID 1000000273657 1000000273657 researchmap permalink read0046473 read0046473 Scopus Author ID 7004501837 7004501837 著者名 Inohara, Hidenori
	NRID 1000050294070 1000050294070 researchmap permalink 3430 3430 Scopus Author ID 7006024942 7006024942 著者名 Tomiyama, Noriyuki
内容	Tatsumi M., Tanaka H., Takenaka Y., et al. Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma. Scientific Reports 14, 3278 (2024); https://doi.org/10.1038/s41598-024-53894-4.
抄録	Circulating tumor DNA (ctDNA), which circulates in the blood after being shed from cancer cells in the body, has recently gained attention as an excellent tumor marker. The purpose of this study was to evaluate whether ct human papillomavirus (HPV) 16 DNA (ctHPV16DNA) levels were associated with quantitative PET parameters in patients with HPV-positive head and neck (HN) squamous cell carcinoma (SCC). Fifty patients with oropharyngeal SCC (OPSCC) and 5 with SCC of unknown primary (SCCUP) before treatment were included. They all underwent blood sampling to test ctHPV16DNA levels and FDG PET-CT examinations. Quantitative PET parameters included SUVmax, metabolic tumor volume (MTV), MTV of whole-body lesions (wbMTV), and 56 texture features. ctHPV16DNA levels were compared to texture features of primary tumors in OPSCC patients (Group A) or the largest primary or metastatic lymph node lesions in OPSCC and SCCUP patients (Group B) and to other PET parameters. Spearman rank correlation test and multiple regression analysis were used to confirm the associations between ctHPV16DNA levels and PET parameters. ctHPV16DNA levels moderately correlated with wbMTV, but not with SUVmax or MTV in Groups A and B. ctHPV16DNA levels exhibited a weak negative correlation with low gray-level zone emphasis in Groups A and B. Multiple regression analysis revealed that wbMTV and high gray-level zone emphasis were the significant factors for ctHPV16DNA levels in Group B. These results were not observed in Group A. This study demonstrated that ctHPV16DNA levels correlated with the whole-body tumor burden and tumor heterogeneity visualized on FDG PET-CT in patients with HPV-positive HNSCC.
出版者	Nature Research
収録物名	Scientific Reports
巻(号)	14(1)
ページ	3278
刊行年月	2024-02-08
言語	英語
ハンドルURL	https://hdl.handle.net/11094/94886
eISSN	20452322
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41598-024-53894-4
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Scientific Reports. 2024, 14(1), p. 3278
DC.title	Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma
DC.creator	Tatsumi, Mitsuaki
	Tanaka, Hidenori
	Takenaka, Yukinori
	Suzuki, Motoyuki
	Fukusumi, Takahito
	Eguchi, Hirotaka
	Watabe, Tadashi
	Kato, Hiroki
	Yachida, Shinichi
	Inohara, Hidenori
	Tomiyama, Noriyuki
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-02-08
DC.identifier	https://doi.org/10.1038/s41598-024-53894-4
DC.description	Tatsumi M., Tanaka H., Takenaka Y., et al. Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma. Scientific Reports 14, 3278 (2024); https://doi.org/10.1038/s41598-024-53894-4.
DCTERMS.abstract	Circulating tumor DNA (ctDNA), which circulates in the blood after being shed from cancer cells in the body, has recently gained attention as an excellent tumor marker. The purpose of this study was to evaluate whether ct human papillomavirus (HPV) 16 DNA (ctHPV16DNA) levels were associated with quantitative PET parameters in patients with HPV-positive head and neck (HN) squamous cell carcinoma (SCC). Fifty patients with oropharyngeal SCC (OPSCC) and 5 with SCC of unknown primary (SCCUP) before treatment were included. They all underwent blood sampling to test ctHPV16DNA levels and FDG PET-CT examinations. Quantitative PET parameters included SUVmax, metabolic tumor volume (MTV), MTV of whole-body lesions (wbMTV), and 56 texture features. ctHPV16DNA levels were compared to texture features of primary tumors in OPSCC patients (Group A) or the largest primary or metastatic lymph node lesions in OPSCC and SCCUP patients (Group B) and to other PET parameters. Spearman rank correlation test and multiple regression analysis were used to confirm the associations between ctHPV16DNA levels and PET parameters. ctHPV16DNA levels moderately correlated with wbMTV, but not with SUVmax or MTV in Groups A and B. ctHPV16DNA levels exhibited a weak negative correlation with low gray-level zone emphasis in Groups A and B. Multiple regression analysis revealed that wbMTV and high gray-level zone emphasis were the significant factors for ctHPV16DNA levels in Group B. These results were not observed in Group A. This study demonstrated that ctHPV16DNA levels correlated with the whole-body tumor burden and tumor heterogeneity visualized on FDG PET-CT in patients with HPV-positive HNSCC.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	94886
citation_title	Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma
citation_author	Tatsumi, Mitsuaki
	Tanaka, Hidenori
	Takenaka, Yukinori
	Suzuki, Motoyuki
	Fukusumi, Takahito
	Eguchi, Hirotaka
	Watabe, Tadashi
	Kato, Hiroki
	Yachida, Shinichi
	Inohara, Hidenori
	Tomiyama, Noriyuki
citation_publisher	Nature Research
citation_language	英語
citation_date	2024-02-08
citation_journal_title	Scientific Reports
citation_volume	14
citation_issue	1
citation_firstpage	3278
citation_doi	https://doi.org/10.1038/s41598-024-53894-4
citation_public_url	https://hdl.handle.net/11094/94886

Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma

閲覧可能ファイル

論文情報

論文詳細を表示