Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort

Kubota, Hiroshi; Fukushima, Yoko; Kawasaki, Ryo; Endo, Takao; Hatsukawa, Yoshikazu; Ineyama, Hiromi; Hirata, Katsuya; Hirano, Shinya; Wada, Kazuko; Nishida, Kohji

doi:https://doi.org/10.1136/bjo-2023-324225

Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort

Kubota, Hiroshi; Fukushima, Yoko; Kawasaki, Ryo et al.

British Journal of Ophthalmology, 2024, 108(9), bjo-2023-324225

アクセス数:841件（2025-08-16 13:42 集計）

固定URL: https://hdl.handle.net/11094/94896

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タイトル	Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort
著者	著者名 Kubota, Hiroshi
	NRID 1000070647031 1000070647031 ORCID 0000-0001-7909-7332 0000-0001-7909-7332 researchmap permalink Fukushima_0812 Fukushima_0812 Scopus Author ID 8316367400 8316367400 著者名 Fukushima, Yoko
	NRID 1000070301067 1000070301067 ORCID 0000-0002-7492-6303 0000-0002-7492-6303 researchmap permalink ryok ryok Scopus Author ID 35229910100 35229910100 著者名 Kawasaki, Ryo
	著者名 Endo, Takao
	著者名 Hatsukawa, Yoshikazu
	著者名 Ineyama, Hiromi
	NRID 1000030724306 1000030724306 著者名 Hirata, Katsuya
	著者名 Hirano, Shinya
	著者名 Wada, Kazuko
	NRID 1000040244610 1000040244610 ORCID 0000-0001-9069-3610 0000-0001-9069-3610 researchmap permalink read0131487 read0131487 Scopus Author ID 57211973404 57211973404 著者名 Nishida, Kohji
内容	Kubota H., Fukushima Y., Kawasaki R., et al. Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort. British Journal of Ophthalmology , bjo-2023-324225 (2024); https://doi.org/10.1136/bjo-2023-324225.
抄録	Background/aims : We assessed the associations between retinopathy of prematurity (ROP) and continuous measurements of oxygen saturation (SpO2), and developed a risk prediction model for severe ROP using birth data and SpO2 data. Methods : This retrospective study included infants who were born before 30 weeks of gestation between August 2009 and January 2019 and who were screened for ROP at a single hospital in Japan. We extracted data on birth weight (BW), birth length, gestational age (GA) and minute-by-minute SpO2 during the first 20 days from the medical records. We defined four SpO2 variables using sequential measurements. Multivariate logistic regression was used to develop a model that combined birth data and SpO2 data to predict treatment-requiring ROP (TR-ROP). The model’s performance was evaluated using the area under the receiver operating characteristic curve (AUC). Results : Among 350 infants, 83 (23.7%) required ROP treatment. The SpO2 variables in infants with TR-ROP differed significantly from those with non-TR-ROP. The average SpO2 and high SpO2 showed strong associations with GA (r=0.73 and r=0.70, respectively). The model incorporating birth data and the four SpO2 variables demonstrated good discriminative ability (AUC=0.83), but it did not outperform the model incorporating BW and GA (AUC=0.82). Conclusion Data obtained by continuous SpO2 monitoring demonstrated valuable associations with severe ROP, as well as with GA. Differences in the distribution of average SpO2 and high SpO2 between infants with TR-ROP and non-TR-ROP could be used to establish efficient cut-off values for risk determination.
出版者	BMJ Publishing Group
収録物名	British Journal of Ophthalmology
巻(号)	108(9)
ページ	bjo-2023-324225
刊行年月	2024-03-06
言語	英語
ハンドルURL	https://hdl.handle.net/11094/94896
PISSN	00071161
eISSN	14682079
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1136/bjo-2023-324225
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	British Journal of Ophthalmology. 2024, 108(9), p. bjo-2023-324225
DC.title	Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort
DC.creator	Kubota, Hiroshi
	Fukushima, Yoko
	Kawasaki, Ryo
	Endo, Takao
	Hatsukawa, Yoshikazu
	Ineyama, Hiromi
	Hirata, Katsuya
	Hirano, Shinya
	Wada, Kazuko
	Nishida, Kohji
DC.publisher	BMJ Publishing Group
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-03-06
DC.identifier	https://doi.org/10.1136/bjo-2023-324225
DC.description	Kubota H., Fukushima Y., Kawasaki R., et al. Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort. British Journal of Ophthalmology , bjo-2023-324225 (2024); https://doi.org/10.1136/bjo-2023-324225.
DCTERMS.abstract	Background/aims : We assessed the associations between retinopathy of prematurity (ROP) and continuous measurements of oxygen saturation (SpO2), and developed a risk prediction model for severe ROP using birth data and SpO2 data. Methods : This retrospective study included infants who were born before 30 weeks of gestation between August 2009 and January 2019 and who were screened for ROP at a single hospital in Japan. We extracted data on birth weight (BW), birth length, gestational age (GA) and minute-by-minute SpO2 during the first 20 days from the medical records. We defined four SpO2 variables using sequential measurements. Multivariate logistic regression was used to develop a model that combined birth data and SpO2 data to predict treatment-requiring ROP (TR-ROP). The model’s performance was evaluated using the area under the receiver operating characteristic curve (AUC). Results : Among 350 infants, 83 (23.7%) required ROP treatment. The SpO2 variables in infants with TR-ROP differed significantly from those with non-TR-ROP. The average SpO2 and high SpO2 showed strong associations with GA (r=0.73 and r=0.70, respectively). The model incorporating birth data and the four SpO2 variables demonstrated good discriminative ability (AUC=0.83), but it did not outperform the model incorporating BW and GA (AUC=0.82). Conclusion Data obtained by continuous SpO2 monitoring demonstrated valuable associations with severe ROP, as well as with GA. Differences in the distribution of average SpO2 and high SpO2 between infants with TR-ROP and non-TR-ROP could be used to establish efficient cut-off values for risk determination.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	94896
citation_title	Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort
citation_author	Kubota, Hiroshi
	Fukushima, Yoko
	Kawasaki, Ryo
	Endo, Takao
	Hatsukawa, Yoshikazu
	Ineyama, Hiromi
	Hirata, Katsuya
	Hirano, Shinya
	Wada, Kazuko
	Nishida, Kohji
citation_publisher	BMJ Publishing Group
citation_language	英語
citation_date	2024-03-06
citation_journal_title	British Journal of Ophthalmology
citation_volume	108
citation_issue	9
citation_firstpage	bjo-2023-324225
citation_doi	https://doi.org/10.1136/bjo-2023-324225
citation_public_url	https://hdl.handle.net/11094/94896

Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort

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