The significant role of glycosaminoglycans in tooth development

Inubushi, Toshihiro; Nag, Priyanka; Sasaki, Jun-Ichi et al.

Glycobiology, 2024, 34(5), cwae024

アクセス数:845件（2025-08-15 15:53 集計）

固定URL: https://hdl.handle.net/11094/95648

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タイトル
The significant role of glycosaminoglycans in tooth development
著者
NRID
1000030550941 1000030550941
researchmap permalink
opathone0141 opathone0141
Scopus Author ID
23097933700 23097933700
ORCID
0000-0001-5303-4763 0000-0001-5303-4763
著者名
Inubushi, Toshihiro
著者名
Nag, Priyanka
NRID
1000050530490 1000050530490
researchmap permalink
Sasaki_JI Sasaki_JI
Scopus Author ID
36138008500 36138008500
著者名
Sasaki, Jun-Ichi
NRID
1000040912457 1000040912457
researchmap permalink
shiraishiyuki shiraishiyuki
著者名
Shiraishi, Yuki
NRID
1000070294428 1000070294428
ORCID
0000-0002-4419-9643 0000-0002-4419-9643
researchmap permalink
read0051793 read0051793
Scopus Author ID
55416765600 55416765600
著者名
Yamashiro, Takashi
キーワード等
extracellular matrix
glycosaminoglycan
hyaluronic acid
proteoglycan
tooth development
内容
Inubushi T., Nag P., Sasaki J.I., et al. The significant role of glycosaminoglycans in tooth development. Glycobiology 34, cwae024 (2024); https://doi.org/10.1093/glycob/cwae024.
抄録
This review delves into the roles of glycosaminoglycans (GAGs), integral components of proteoglycans, in tooth development. Proteoglycans consist of a core protein linked to GAG chains, comprised of repeating disaccharide units. GAGs are classified into several types, such as hyaluronic acid, heparan sulfate, chondroitin sulfate, dermatan sulfate, and keratan sulfate. Functioning as critical macromolecular components within the dental basement membrane, these GAGs facilitate cell adhesion and aggregation, and play key roles in regulating cell proliferation and differentiation, thereby significantly influencing tooth morphogenesis. Notably, our recent research has identified the hyaluronan-degrading enzyme Transmembrane protein 2 (Tmem2) and we have conducted functional analyses using mouse models. These studies have unveiled the essential role of Tmem2-mediated hyaluronan degradation and its involvement in hyaluronan-mediated cell adhesion during tooth formation. This review provides a comprehensive summary of the current understanding of GAG functions in tooth development, integrating insights from recent research, and discusses future directions in this field.
出版者
Oxford University Press
収録物名
Glycobiology
巻(号)
34(5)
ページ
cwae024
刊行年月
2024-05-01
言語
英語
ハンドルURL
https://hdl.handle.net/11094/95648
PISSN
09596658
eISSN
14602423
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1093/glycob/cwae024
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article