RN7SL1 may be translated under oncogenic conditions

Hara, Tomoaki; Meng, Sikun; Tsuji, Yoshiko; Arao, Yasuko; Saito, Yoshiko; Sato, Hiromichi; Motooka, Daisuke; Uchida, Shizuka; Ishii, Hideshi

doi:https://doi.org/10.1073/pnas.2312322121

RN7SL1 may be translated under oncogenic conditions

Hara, Tomoaki; Meng, Sikun; Tsuji, Yoshiko et al.

Proceedings of the National Academy of Sciences of the United States of America, 2024, 121(12)

アクセス数:478件（2025-06-24 13:57 集計）

固定URL: https://hdl.handle.net/11094/95672

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タイトル	RN7SL1 may be translated under oncogenic conditions
著者	NRID 1000030779161 1000030779161 researchmap permalink registered20221012 registered20221012 著者名 Hara, Tomoaki
	NRID 1000050977204 1000050977204 researchmap permalink sikunmeng sikunmeng 著者名 Meng, Sikun
	著者名 Tsuji, Yoshiko
	NRID 1000070962736 1000070962736 著者名 Arao, Yasuko
	著者名 Saito, Yoshiko
	著者名 Sato, Hiromichi
	NRID 1000010636830 1000010636830 researchmap permalink daisukem daisukem Scopus Author ID 35315737900 35315737900 著者名 Motooka, Daisuke
	著者名 Uchida, Shizuka
	NRID 1000010280736 1000010280736 researchmap permalink read0103186 read0103186 Scopus Author ID 7402978600 7402978600 著者名 Ishii, Hideshi
キーワード等	ncRNA
	RN7SL1
	smORF
内容	Hara T., Meng S., Tsuji Y., et al. RN7SL1 may be translated under oncogenic conditions. Proceedings of the National Academy of Sciences of the United States of America 121, (2024); https://doi.org/10.1073/pnas.2312322121.
抄録	RN7SL1 (RNA component of signal recognition particle 7SL1), a component of the signal recognition particle, is a non-coding RNA possessing a small ORF (smORF). However, whether it is translated into peptides is unknown. Here, we generated the RN7SL1-Green Fluorescent Protein (GFP) gene, in which the smORF of RN7SL1 was replaced by GFP, introduced it into 293T cells, and observed cells emitting GFP fluorescence. Furthermore, RNA-seq of GFP-positive cells revealed that they were in an oncogenic state, suggesting that RN7SL1 smORF may be translated under special conditions.
出版者	National Academy of Sciences
収録物名	Proceedings of the National Academy of Sciences of the United States of America
巻(号)	121(12)
刊行年月	2024-03-19
言語	英語
ハンドルURL	https://hdl.handle.net/11094/95672
eISSN	10916490
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1073/pnas.2312322121
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Proceedings of the National Academy of Sciences of the United States of America. 2024, 121(12)
DC.title	RN7SL1 may be translated under oncogenic conditions
DC.creator	Hara, Tomoaki
	Meng, Sikun
	Tsuji, Yoshiko
	Arao, Yasuko
	Saito, Yoshiko
	Sato, Hiromichi
	Motooka, Daisuke
	Uchida, Shizuka
	Ishii, Hideshi
DC.publisher	National Academy of Sciences
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-03-19
DC.identifier	https://doi.org/10.1073/pnas.2312322121
DC.subject	ncRNA
	RN7SL1
	smORF
DC.description	Hara T., Meng S., Tsuji Y., et al. RN7SL1 may be translated under oncogenic conditions. Proceedings of the National Academy of Sciences of the United States of America 121, (2024); https://doi.org/10.1073/pnas.2312322121.
DCTERMS.abstract	RN7SL1 (RNA component of signal recognition particle 7SL1), a component of the signal recognition particle, is a non-coding RNA possessing a small ORF (smORF). However, whether it is translated into peptides is unknown. Here, we generated the RN7SL1-Green Fluorescent Protein (GFP) gene, in which the smORF of RN7SL1 was replaced by GFP, introduced it into 293T cells, and observed cells emitting GFP fluorescence. Furthermore, RNA-seq of GFP-positive cells revealed that they were in an oncogenic state, suggesting that RN7SL1 smORF may be translated under special conditions.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	95672
citation_title	RN7SL1 may be translated under oncogenic conditions
citation_author	Hara, Tomoaki
	Meng, Sikun
	Tsuji, Yoshiko
	Arao, Yasuko
	Saito, Yoshiko
	Sato, Hiromichi
	Motooka, Daisuke
	Uchida, Shizuka
	Ishii, Hideshi
citation_publisher	National Academy of Sciences
citation_language	英語
citation_date	2024-03-19
citation_journal_title	Proceedings of the National Academy of Sciences of the United States of America
citation_volume	121
citation_issue	12
citation_doi	https://doi.org/10.1073/pnas.2312322121
citation_public_url	https://hdl.handle.net/11094/95672

RN7SL1 may be translated under oncogenic conditions

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