Plasma Concentration of Antifungal Agent Micafungin for Pediatric Living Donor Liver Transplantation

Ueno, Takehisa; Takase, Koki; Deguchi, Koichi; Nomura, Motonari; Watanabe, Miho; Kamiyama, Masafumi; Tazuke, Yuko; Kimura, Takeshi; Okuyama, Hiroomi

doi:https://doi.org/10.1016/j.transproceed.2024.01.020

Plasma Concentration of Antifungal Agent Micafungin for Pediatric Living Donor Liver Transplantation

Ueno, Takehisa; Takase, Koki; Deguchi, Koichi et al.

Transplantation Proceedings, 2024, 56(3), 602-604

アクセス数:1,282件（2025-07-26 12:25 集計）

固定URL: https://hdl.handle.net/11094/95862

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タイトル	Plasma Concentration of Antifungal Agent Micafungin for Pediatric Living Donor Liver Transplantation
著者	NRID 1000010456957 1000010456957 ORCID 0000-0002-4639-8814 0000-0002-4639-8814 researchmap permalink ueno-pedsurg ueno-pedsurg Scopus Author ID 21743992300 21743992300 著者名 Ueno, Takehisa
	NRID 1000080961763 1000080961763 著者名 Takase, Koki
	NRID 1000000747082 1000000747082 researchmap permalink deguchi_koichi deguchi_koichi Scopus Author ID 57139781700 57139781700 著者名 Deguchi, Koichi
	NRID 1000040546909 1000040546909 researchmap permalink moto_pedsurg moto_pedsurg Scopus Author ID 35208741700 35208741700 ORCID 0009-0004-0959-7461 0009-0004-0959-7461 著者名 Nomura, Motonari
	NRID 1000040791728 1000040791728 researchmap permalink miho miho Scopus Author ID 56282966800 56282966800 ORCID 0000-0001-6691-0611 0000-0001-6691-0611 著者名 Watanabe, Miho
	NRID 1000020403074 1000020403074 researchmap permalink kamiyamapedsurg kamiyamapedsurg Scopus Author ID 55559187300 55559187300 著者名 Kamiyama, Masafumi
	NRID 1000010397698 1000010397698 researchmap permalink yukotazuke-osaka yukotazuke-osaka Scopus Author ID 7006109798 7006109798 ORCID 0000-0002-8335-0414 0000-0002-8335-0414 著者名 Tazuke, Yuko
	NRID 1000050774402 1000050774402 researchmap permalink kimutake kimutake Scopus Author ID 57205488897 57205488897 著者名 Kimura, Takeshi
	NRID 1000030252670 1000030252670 researchmap permalink okuyamahiroomi okuyamahiroomi Scopus Author ID 35496082300 35496082300 ORCID 0000-0002-1347-282X 0000-0002-1347-282X 著者名 Okuyama, Hiroomi
内容	Ueno T., Takase K., Deguchi K., et al. Plasma Concentration of Antifungal Agent Micafungin for Pediatric Living Donor Liver Transplantation. Transplantation Proceedings 56, 602 (2024); https://doi.org/10.1016/j.transproceed.2024.01.020.
抄録	Background: Pediatric living-donor liver transplantation (LDLT) candidates often receive long-term antibiotic treatment. Micafungin has been used as an antifungal agent after LDLT, but the adequate dose after pediatric LDLT was unknown. Here, we report micafungin blood concentrations after pediatric LDLT and discuss its safety and adequate dosing. Methods: Pediatric patients with data on micafungin concentrations after LDLT were identified. Those with surgical complications were excluded. All patients received standard tacrolimus-based immunosuppression. A micafungin dose of 1 mg/kg was administered once daily for 10 days starting on postoperative day (POD) 1. The trough and peak micafungin blood concentrations were evaluated on PODs 1, 4, 7, and 10. Beta D glucan levels and liver function tests were assessed to determine micafungin effectiveness and safety. Results: Ten patients were enrolled, with a median age of 1.2 years. The median graft vs body weight ratio was 2.7%. The primary diseases were biliary atresia (n = 7), Alagille syndrome (n = 2), and progressive familial intrahepatic cholestasis type 2 (n = 1). Mean peak micafungin levels were 4.47, 6.27, 5.47, and 5.47 µg/mL on PODs 1, 4, 7, and 10, respectively. Mean trough levels were 2.03, 1.88, and 2.66 µg/mL on PODs 4, 7, and 10, respectively. The micafungin half-lives were 13.7, 14.7, and 14.0 hours on PODs 4, 7, and 10, respectively. Beta D glucan levels were 4.4 pg/mL and 3.7 pg/mL before and after transplantation, respectively, indicating no significant difference (P = .3). No clinical fungal infections were observed. Conclusion: Micafungin administration is safe and effective after pediatric LDLT.
出版者	Elsevier Inc.
収録物名	Transplantation Proceedings
巻(号)	56(3)
ページ	602-604
刊行年月	2024-04-25
言語	英語
ハンドルURL	https://hdl.handle.net/11094/95862
PISSN	00411345
eISSN	18732623
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1016/j.transproceed.2024.01.020
アクセス権	open access
権利情報	©2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Transplantation Proceedings. 2024, 56(3), p. 602-604
DC.title	Plasma Concentration of Antifungal Agent Micafungin for Pediatric Living Donor Liver Transplantation
DC.creator	Ueno, Takehisa
	Takase, Koki
	Deguchi, Koichi
	Nomura, Motonari
	Watanabe, Miho
	Kamiyama, Masafumi
	Tazuke, Yuko
	Kimura, Takeshi
	Okuyama, Hiroomi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-04-25
DC.identifier	https://doi.org/10.1016/j.transproceed.2024.01.020
DC.description	Ueno T., Takase K., Deguchi K., et al. Plasma Concentration of Antifungal Agent Micafungin for Pediatric Living Donor Liver Transplantation. Transplantation Proceedings 56, 602 (2024); https://doi.org/10.1016/j.transproceed.2024.01.020.
DCTERMS.abstract	Background: Pediatric living-donor liver transplantation (LDLT) candidates often receive long-term antibiotic treatment. Micafungin has been used as an antifungal agent after LDLT, but the adequate dose after pediatric LDLT was unknown. Here, we report micafungin blood concentrations after pediatric LDLT and discuss its safety and adequate dosing. Methods: Pediatric patients with data on micafungin concentrations after LDLT were identified. Those with surgical complications were excluded. All patients received standard tacrolimus-based immunosuppression. A micafungin dose of 1 mg/kg was administered once daily for 10 days starting on postoperative day (POD) 1. The trough and peak micafungin blood concentrations were evaluated on PODs 1, 4, 7, and 10. Beta D glucan levels and liver function tests were assessed to determine micafungin effectiveness and safety. Results: Ten patients were enrolled, with a median age of 1.2 years. The median graft vs body weight ratio was 2.7%. The primary diseases were biliary atresia (n = 7), Alagille syndrome (n = 2), and progressive familial intrahepatic cholestasis type 2 (n = 1). Mean peak micafungin levels were 4.47, 6.27, 5.47, and 5.47 µg/mL on PODs 1, 4, 7, and 10, respectively. Mean trough levels were 2.03, 1.88, and 2.66 µg/mL on PODs 4, 7, and 10, respectively. The micafungin half-lives were 13.7, 14.7, and 14.0 hours on PODs 4, 7, and 10, respectively. Beta D glucan levels were 4.4 pg/mL and 3.7 pg/mL before and after transplantation, respectively, indicating no significant difference (P = .3). No clinical fungal infections were observed. Conclusion: Micafungin administration is safe and effective after pediatric LDLT.
DC.rights	©2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.format	95862
citation_title	Plasma Concentration of Antifungal Agent Micafungin for Pediatric Living Donor Liver Transplantation
citation_author	Ueno, Takehisa
	Takase, Koki
	Deguchi, Koichi
	Nomura, Motonari
	Watanabe, Miho
	Kamiyama, Masafumi
	Tazuke, Yuko
	Kimura, Takeshi
	Okuyama, Hiroomi
citation_publisher	Elsevier Inc.
citation_language	英語
citation_date	2024-04-25
citation_journal_title	Transplantation Proceedings
citation_volume	56
citation_issue	3
citation_firstpage	602
citation_lastpage	604
citation_doi	https://doi.org/10.1016/j.transproceed.2024.01.020
citation_public_url	https://hdl.handle.net/11094/95862

Plasma Concentration of Antifungal Agent Micafungin for Pediatric Living Donor Liver Transplantation

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