Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia

Yuba, Tomoo; Koyama, Yoshihisa; Kinishi, Yuki; Uokawa, Reiko; Ootaki, Chiyo; Shimada, Shoichi; Fujino, Yuji

doi:https://doi.org/10.1007/s43032-024-01580-1

Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia

Yuba, Tomoo; Koyama, Yoshihisa; Kinishi, Yuki et al.

Reproductive Sciences, 2024, 31(9), 2753-2762

アクセス数:781件（2025-07-12 00:00 集計）

固定URL: https://hdl.handle.net/11094/97117

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タイトル	Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia
著者	著者名 Yuba, Tomoo
	NRID 1000040397667 1000040397667 researchmap permalink koyamayoshihisa koyamayoshihisa Scopus Author ID 49761644100 49761644100 著者名 Koyama, Yoshihisa
	著者名 Kinishi, Yuki
	著者名 Uokawa, Reiko
	NRID 1000000742248 1000000742248 researchmap permalink otc5386 otc5386 Scopus Author ID 14045558000 14045558000 著者名 Ootaki, Chiyo
	NRID 1000020216063 1000020216063 researchmap permalink 556shimada 556shimada Scopus Author ID 35452177800 35452177800 ORCID 0000-0001-5369-1069 0000-0001-5369-1069 著者名 Shimada, Shoichi
	NRID 1000050252672 1000050252672 researchmap permalink y_fujino y_fujino Scopus Author ID 19134445600 19134445600 著者名 Fujino, Yuji
キーワード等	Fetus
	Labor epidural analgesia
	Mother
	Oxidative stress
内容	The version of record of this article, first published in Reproductive Sciences, is available online at Publisher’s website: https://doi.org/10.1007/s43032-024-01580-1.
抄録	Childbirth is a stressful event for mothers, and labor epidural analgesia (LEA) may reduce mental stress. Mental stressors include labor pain, fear, and anxiety, which induce oxidative stress. In this study, we focused on oxidative stress during delivery and conducted a cross-sectional analysis of maternal and fetal oxidative stress. The participants included 15 women who received LEA (LEA group) and 15 who did not (No LEA group). Participants with a gestational age of < 37 weeks, BMI of ≥ 35 kg/m2, cerebrovascular or cardiovascular complications, multiple pregnancies, gestational hypertension, gestational diabetes, chronic hypertension, thyroid disease, birth weight of < 2,500 g, emergency cesarean section, or cases in which epidural anesthesia was re-administered during delivery were excluded from the study. Maternal blood was collected on admission, and immediately after delivery, and umbilical artery blood was collected from the fetus. The oxidative stress status was assessed by measuring diacron-reactive oxygen metabolite (an index of the degree of lipid peroxide oxidation), biological antioxidant potential (an index of antioxidant capacity) and calculating the ratio of BAP/d-ROMs (an index of the oxidative stress). The results showed that maternal oxidative stress immediately after delivery was lower in the LEA group than in the No LEA group. Moreover, the fetuses experienced less oxidative stress in the LEA group than in the No LEA group. Taken together, these results suggest that LEA may reduce maternal and fetal oxidative stress associated with childbirth.
出版者	Springer Nature
収録物名	Reproductive Sciences
巻(号)	31(9)
ページ	2753-2762
刊行年月	2024-05-10
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97117
PISSN	19337191
eISSN	19337205
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s43032-024-01580-1
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Reproductive Sciences. 2024, 31(9), p. 2753-2762
DC.title	Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia
DC.creator	Yuba, Tomoo
	Koyama, Yoshihisa
	Kinishi, Yuki
	Uokawa, Reiko
	Ootaki, Chiyo
	Shimada, Shoichi
	Fujino, Yuji
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-10
DC.identifier	https://doi.org/10.1007/s43032-024-01580-1
DC.subject	Fetus
	Labor epidural analgesia
	Mother
	Oxidative stress
DC.description	The version of record of this article, first published in Reproductive Sciences, is available online at Publisher’s website: https://doi.org/10.1007/s43032-024-01580-1.
DCTERMS.abstract	Childbirth is a stressful event for mothers, and labor epidural analgesia (LEA) may reduce mental stress. Mental stressors include labor pain, fear, and anxiety, which induce oxidative stress. In this study, we focused on oxidative stress during delivery and conducted a cross-sectional analysis of maternal and fetal oxidative stress. The participants included 15 women who received LEA (LEA group) and 15 who did not (No LEA group). Participants with a gestational age of < 37 weeks, BMI of ≥ 35 kg/m2, cerebrovascular or cardiovascular complications, multiple pregnancies, gestational hypertension, gestational diabetes, chronic hypertension, thyroid disease, birth weight of < 2,500 g, emergency cesarean section, or cases in which epidural anesthesia was re-administered during delivery were excluded from the study. Maternal blood was collected on admission, and immediately after delivery, and umbilical artery blood was collected from the fetus. The oxidative stress status was assessed by measuring diacron-reactive oxygen metabolite (an index of the degree of lipid peroxide oxidation), biological antioxidant potential (an index of antioxidant capacity) and calculating the ratio of BAP/d-ROMs (an index of the oxidative stress). The results showed that maternal oxidative stress immediately after delivery was lower in the LEA group than in the No LEA group. Moreover, the fetuses experienced less oxidative stress in the LEA group than in the No LEA group. Taken together, these results suggest that LEA may reduce maternal and fetal oxidative stress associated with childbirth.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97117
citation_title	Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia
citation_author	Yuba, Tomoo
	Koyama, Yoshihisa
	Kinishi, Yuki
	Uokawa, Reiko
	Ootaki, Chiyo
	Shimada, Shoichi
	Fujino, Yuji
citation_publisher	Springer Nature
citation_language	英語
citation_date	2024-05-10
citation_journal_title	Reproductive Sciences
citation_volume	31
citation_issue	9
citation_firstpage	2753
citation_lastpage	2762
citation_doi	https://doi.org/10.1007/s43032-024-01580-1
citation_public_url	https://hdl.handle.net/11094/97117

Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia

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