Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water

Matsumura, Erika; Nohara, Kanji; Fukatsu, Hikari; Tanaka, Nobukazu; Fujii, Nami; Sakai, Takayoshi

doi:https://doi.org/10.1007/s00455-024-10704-3

Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water

Matsumura, Erika; Nohara, Kanji; Fukatsu, Hikari et al.

Dysphagia, 2024, 40(1), 70-76

アクセス数:531件（2025-07-12 13:51 集計）

固定URL: https://hdl.handle.net/11094/97120

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タイトル	Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water
著者	著者名 Matsumura, Erika
	NRID 1000020346167 1000020346167 researchmap permalink read0093430 read0093430 Scopus Author ID 7004385707 7004385707 著者名 Nohara, Kanji
	著者名 Fukatsu, Hikari
	NRID 1000020570295 1000020570295 researchmap permalink hal-1008 hal-1008 Scopus Author ID 55702171000 55702171000 著者名 Tanaka, Nobukazu
	著者名 Fujii, Nami
	NRID 1000090379082 1000090379082 ORCID 0000-0003-4348-4896 0000-0003-4348-4896 researchmap permalink read0210126 read0210126 Scopus Author ID 55177911100 55177911100 著者名 Sakai, Takayoshi
キーワード等	Aspiration pneumonia
	Dysphagia
	Mucociliary transport function
	Saccharine dye test
	Thickening agent
	Viscosity
内容	The version of record of this article, first published in Dysphagia, is available online at Publisher’s website: https://doi.org/10.1007/s00455-024-10704-3.
抄録	Thickening agents effectively prevent liquid aspiration, but their impact on the ease of discharging aspirated liquids from the trachea remains unclear due to alterations in the physical properties of liquids. This study clarifies the effects of thickening agents, comprising various raw materials, on mucociliary transport function, focusing on the viscosities of thickened waters. The subjects were 23 healthy adults. Five types of saccharin solution were prepared: a solution without a thickening agent, a starch-based nectar-like solution, a starch-based honey-like solution, a xanthan-gum-based nectar-like solution, and a xanthan-gum-based honey-like solution. Using these five types of saccharin solutions randomly, each subject underwent five trials of the saccharine dye test to evaluate the mucociliary transport function of the respiratory tract. The saccharin time was defined as the time from the placement of the saccharin solution on the nasal vestibule of the subject to when the subject reported that they became aware of the sweetness. The saccharin transit times for all samples of thickened water were longer compared to those of water without a thickening agent (p < 0.01). A comparison between thickened water samples with different viscosities showed that the saccharin transit time was longer when thickened water samples with high viscosity were prepared using the same thickening agent (p < 0.01). This suggests that while thickening reduces aspiration, the use of thickening agents may increase the difficulty in discharging aspirated fluids from the trachea.
出版者	Springer
収録物名	Dysphagia
巻(号)	40(1)
ページ	70-76
刊行年月	2024-05-22
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97120
PISSN	0179051X
eISSN	14320460
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s00455-024-10704-3
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Dysphagia. 2024, 40(1), p. 70-76
DC.title	Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water
DC.creator	Matsumura, Erika
	Nohara, Kanji
	Fukatsu, Hikari
	Tanaka, Nobukazu
	Fujii, Nami
	Sakai, Takayoshi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-22
DC.identifier	https://doi.org/10.1007/s00455-024-10704-3
DC.subject	Aspiration pneumonia
	Dysphagia
	Mucociliary transport function
	Saccharine dye test
	Thickening agent
	Viscosity
DC.description	The version of record of this article, first published in Dysphagia, is available online at Publisher’s website: https://doi.org/10.1007/s00455-024-10704-3.
DCTERMS.abstract	Thickening agents effectively prevent liquid aspiration, but their impact on the ease of discharging aspirated liquids from the trachea remains unclear due to alterations in the physical properties of liquids. This study clarifies the effects of thickening agents, comprising various raw materials, on mucociliary transport function, focusing on the viscosities of thickened waters. The subjects were 23 healthy adults. Five types of saccharin solution were prepared: a solution without a thickening agent, a starch-based nectar-like solution, a starch-based honey-like solution, a xanthan-gum-based nectar-like solution, and a xanthan-gum-based honey-like solution. Using these five types of saccharin solutions randomly, each subject underwent five trials of the saccharine dye test to evaluate the mucociliary transport function of the respiratory tract. The saccharin time was defined as the time from the placement of the saccharin solution on the nasal vestibule of the subject to when the subject reported that they became aware of the sweetness. The saccharin transit times for all samples of thickened water were longer compared to those of water without a thickening agent (p < 0.01). A comparison between thickened water samples with different viscosities showed that the saccharin transit time was longer when thickened water samples with high viscosity were prepared using the same thickening agent (p < 0.01). This suggests that while thickening reduces aspiration, the use of thickening agents may increase the difficulty in discharging aspirated fluids from the trachea.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97120
citation_title	Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water
citation_author	Matsumura, Erika
	Nohara, Kanji
	Fukatsu, Hikari
	Tanaka, Nobukazu
	Fujii, Nami
	Sakai, Takayoshi
citation_publisher	Springer
citation_language	英語
citation_date	2024-05-22
citation_journal_title	Dysphagia
citation_volume	40
citation_issue	1
citation_firstpage	70
citation_lastpage	76
citation_doi	https://doi.org/10.1007/s00455-024-10704-3
citation_public_url	https://hdl.handle.net/11094/97120

Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water

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