Three-Year Prospective Follow-up of Potential Pediatric Candidate for Intestinal Transplantation

Ueno, T.; Wada, M.; Hoshino, K.; Matsuura, T.; Ida, S.; Okuyama, H.

doi:https://doi.org/10.1016/J.TRANSPROCEED.2018.03.067

Three-Year Prospective Follow-up of Potential Pediatric Candidate for Intestinal Transplantation

Ueno, T.; Wada, M.; Hoshino, K. et al.

Transplantation Proceedings, 2018, 50(9), 2779-2782

アクセス数:780件（2025-07-03 17:49 集計）

固定URL: https://hdl.handle.net/11094/97126

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タイトル	Three-Year Prospective Follow-up of Potential Pediatric Candidate for Intestinal Transplantation
著者	NRID 1000010456957 1000010456957 ORCID 0000-0002-4639-8814 0000-0002-4639-8814 researchmap permalink ueno-pedsurg ueno-pedsurg Scopus Author ID 21743992300 21743992300 著者名 Ueno, T.
	NRID 1000080372291 1000080372291 著者名 Wada, M.
	NRID 1000070190197 1000070190197 著者名 Hoshino, K.
	NRID 1000010532856 1000010532856 著者名 Matsuura, T.
	著者名 Ida, S.
	NRID 1000030252670 1000030252670 researchmap permalink okuyamahiroomi okuyamahiroomi Scopus Author ID 35496082300 35496082300 ORCID 0000-0002-1347-282X 0000-0002-1347-282X 著者名 Okuyama, H.
内容	Ueno T., Wada M., Hoshino K., et al. Three-Year Prospective Follow-up of Potential Pediatric Candidate for Intestinal Transplantation. Transplantation Proceedings 50, 2779 (2018); https://doi.org/10.1016/J.TRANSPROCEED.2018.03.067.
抄録	Intestinal transplantation (ITx) is a treatment for refractory intestinal failure (IF). However, the indications for and timing of ITx are still controversial because the course of IF is unknown. We performed a prospective multi-institutional cohort study to identify the prognostic factors for referral to an ITx facility. Patients under 18 years of age in Japan who suffered from IF and had received parenteral nutrition for longer than 6 months were enrolled in this study. They were followed up for 3 years. Seventy-two patients were followed. The mean age at the beginning of the study was 7.0 years. Diagnoses were short gut syndrome (n = 25), motility disorder (n = 45), and other (n = 2). The overall 3-year survival rate was 95%. The 3-year survival rate was 86% in patients with intestinal-failure-associated liver disease (IFALD) (n = 6) compared to 97% in those without IFALD (n = 66) (P =.0003). Furthermore, the 3-year survival rates of patients who did and did not meet the criteria for ITx were 82% (n = 11) and 97% (n = 62), respectively (P =.034). Six (44%) of 14 patients whose performance status (PS) was ≥3 at enrollment were dead or still had a PS ≥ 3 at 3 years. This study indicates that IFALD is a poor prognostic factor in pediatric patients with IF. Our indication for ITx, namely the presence of IFALD or loss of more than 2 parenteral nutrition access sites, seems to be applicable.
出版者	Elsevier
収録物名	Transplantation Proceedings
巻(号)	50(9)
ページ	2779-2782
刊行年月	2018-11-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97126
PISSN	00411345
eISSN	18732623
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1016/J.TRANSPROCEED.2018.03.067
アクセス権	open access
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Transplantation Proceedings. 2018, 50(9), p. 2779-2782
DC.title	Three-Year Prospective Follow-up of Potential Pediatric Candidate for Intestinal Transplantation
DC.creator	Ueno, T.
	Wada, M.
	Hoshino, K.
	Matsuura, T.
	Ida, S.
	Okuyama, H.
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2018-11-01
DC.identifier	https://doi.org/10.1016/J.TRANSPROCEED.2018.03.067
DC.description	Ueno T., Wada M., Hoshino K., et al. Three-Year Prospective Follow-up of Potential Pediatric Candidate for Intestinal Transplantation. Transplantation Proceedings 50, 2779 (2018); https://doi.org/10.1016/J.TRANSPROCEED.2018.03.067.
DCTERMS.abstract	Intestinal transplantation (ITx) is a treatment for refractory intestinal failure (IF). However, the indications for and timing of ITx are still controversial because the course of IF is unknown. We performed a prospective multi-institutional cohort study to identify the prognostic factors for referral to an ITx facility. Patients under 18 years of age in Japan who suffered from IF and had received parenteral nutrition for longer than 6 months were enrolled in this study. They were followed up for 3 years. Seventy-two patients were followed. The mean age at the beginning of the study was 7.0 years. Diagnoses were short gut syndrome (n = 25), motility disorder (n = 45), and other (n = 2). The overall 3-year survival rate was 95%. The 3-year survival rate was 86% in patients with intestinal-failure-associated liver disease (IFALD) (n = 6) compared to 97% in those without IFALD (n = 66) (P =.0003). Furthermore, the 3-year survival rates of patients who did and did not meet the criteria for ITx were 82% (n = 11) and 97% (n = 62), respectively (P =.034). Six (44%) of 14 patients whose performance status (PS) was ≥3 at enrollment were dead or still had a PS ≥ 3 at 3 years. This study indicates that IFALD is a poor prognostic factor in pediatric patients with IF. Our indication for ITx, namely the presence of IFALD or loss of more than 2 parenteral nutrition access sites, seems to be applicable.
DC.rights	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.format	97126
citation_title	Three-Year Prospective Follow-up of Potential Pediatric Candidate for Intestinal Transplantation
citation_author	Ueno, T.
	Wada, M.
	Hoshino, K.
	Matsuura, T.
	Ida, S.
	Okuyama, H.
citation_publisher	Elsevier
citation_language	英語
citation_date	2018-11-01
citation_journal_title	Transplantation Proceedings
citation_volume	50
citation_issue	9
citation_firstpage	2779
citation_lastpage	2782
citation_doi	https://doi.org/10.1016/J.TRANSPROCEED.2018.03.067
citation_public_url	https://hdl.handle.net/11094/97126

Three-Year Prospective Follow-up of Potential Pediatric Candidate for Intestinal Transplantation

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